Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Arun K Mandagere"'
Autor:
Arun K. Mandagere, Kin-Kai Hwang
Publikováno v:
Journal of Food and Drug Analysis. 1
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 36:447-456
The ability to rapidly and consistently measure aqueous solubility in a preclinical environment is critical to the successful identification of promising discovery compounds. The advantage of an early solubility screen is timely attrition of compound
Autor:
Arun K. Mandagere, Barry Jones
Publikováno v:
Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability
Publikováno v:
Journal of Medicinal Chemistry. 45:304-311
This paper describes a graphical model for simplifying in vitro absorption, metabolism, distribution, and elimination (ADME) data analysis through the estimation of oral bioavailability (%F) of drugs in humans and other species. This model integrates
Autor:
Julie L. Geary, Melinda A. Correll, J. Chuck Poole, Xiao-Gao Liu, Larry D. Bratton, Fred E. Boyer, Thomas N. Thompson, Teng-Man Chen, Arun K. Mandagere, Bryan K. Jones, Kin-Kai Hwang, Mark E. Webster, Robert W. Knippenberg, Maynard George D, Stephen W. Horgan, Deborah E. Logan, Tieu-Binh Le, Kudlacz Elizabeth M, David L. Wenstrup, Burkholder Timothy P, Raymond S. Gross, David W. Freund
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2531-2536
We recently described the synthesis and characterization of MDL 105,212, a non peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors.1 Here we report the synthesis and structure-activity relationships for a series of analogs of M
Publikováno v:
Chirality. 5:428-435
ML-1035, 4-amino-5-chloro-2-[2-(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide, is a sulfoxide compound and a racemic gastroprokinetic agent with a chiral center at the sulfur atom. We have investigated the disposition kinetics of (R)-ML-1
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 9:935-940
A fully automated column-switching LC assay has been developed for the simultaneous determination of a gastroprokinetic agent, ML-1035 sulphoxide, and its sulphone and sulphide metabolites in rat urine. ML-1035 Sulphoxide is a metoclopramide analogue
Publikováno v:
Pharmaceutical Research. :1257-1261
A fully automated HPLC assay for hydrochlorothiazide in plasma has been developed using a column-switching technique. The method involves direct injection of plasma to the extraction column for sample cleanup followed by switching onto the analytical
Autor:
Julie I. Geary, Jim Chang, Thomas N. Thompson, Jan L. Battor, Kin-Kai Hwang, Arun K. Mandagere, Dave R. Osborne, Be-Sheng Kuo, Valerie L. Vaughn
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 9(10-12)
ML-1035, is a gastroprokinetic agent structurally related to metoclopramide. Because ML-1035 contains an asymmetric chiral sulphoxide moiety, a chiral HPLC method has been developed to separate and quantitate its R- and S-enantiomers in plasma. The M