Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Arun K, Shukla"'
Autor:
Manish K. Yadav, Parishmita Sarma, Jagannath Maharana, Manisankar Ganguly, Sudha Mishra, Nashrah Zaidi, Annu Dalal, Vinay Singh, Sayantan Saha, Gargi Mahajan, Saloni Sharma, Mohamed Chami, Ramanuj Banerjee, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The Hydroxycarboxylic acid receptor 2 (HCA2), also known as the niacin receptor or GPR109A, is a prototypical GPCR that plays a central role in the inhibition of lipolytic and atherogenic activities. Its activation also results in vasodilati
Externí odkaz:
https://doaj.org/article/81a025e0280946b39508480f0e82854e
Autor:
Parishmita Sarma, Carlo Marion C. Carino, Deeksha Seetharama, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Xue Rui, Yubo Cao, Kouki Kawakami, Poonam Kumari, Yu-Chih Chen, Kathryn E. Luker, Prem N. Yadav, Gary D. Luker, Stéphane A. Laporte, Xin Chen, Asuka Inoue, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms. Ligand promiscuity among these receptors makes them an interesting
Externí odkaz:
https://doaj.org/article/00c1bfe069ce44fd80ee66e1ab0d2340
Autor:
Khalid M. Alotaibi, Arun K. Shukla, Elham Bajuayfir, Abdullah A. Alotaibi, Mohamed H. Mrad, Fatma A. Gomaa, Abdullah M Alswieleh
Publikováno v:
Ultrasonics Sonochemistry, Vol 98, Iss , Pp 106497- (2023)
Contamination of heavy metal (Cd2+ & Pb2+) ions in drinking water is producing major impacts on the environment and public health and is considered one of the greatest dangers to humanity. Membrane technology has been chosen over other processing met
Externí odkaz:
https://doaj.org/article/ae688bcb2a77413084b5561a38943a95
Autor:
Mithu Baidya, Madhu Chaturvedi, Hemlata Dwivedi-Agnihotri, Ashutosh Ranjan, Dominic Devost, Yoon Namkung, Tomasz Maciej Stepniewski, Shubhi Pandey, Minakshi Baruah, Bhanupriya Panigrahi, Parishmita Sarma, Manish K. Yadav, Jagannath Maharana, Ramanuj Banerjee, Kouki Kawakami, Asuka Inoue, Jana Selent, Stéphane A. Laporte, Terence E. Hébert, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
G protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells.
Externí odkaz:
https://doaj.org/article/b914c159b8f9404cb1ff77ff55de3886
Autor:
Yutaro Shiraishi, Yutaka Kofuku, Takumi Ueda, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Arun K. Shukla, Ichio Shimada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
β-arrestins commonly bind to two distinct elements in GPCRs: the phosphorylated carboxyl terminal tail (C tail) and the cytoplasmic face of the transmembrane region (TM core). Here, the authors use methyl-TROSY NMR measurements to characterise the i
Externí odkaz:
https://doaj.org/article/c2744b4652694e1eb22b0a1f83faea09
Publikováno v:
Trends Pharmacol Sci
Atypical chemokine receptor subtype 3 (ACKR3), a chemokine receptor, couples selectively to β-arrestins (βarrs) but not to G proteins despite having seven transmembrane (7TM) helix architecture. Yen et al. present cryogenic-electron microscopy (cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a1341cfbd7191ba15be614fd57ca92
https://doi.org/10.1016/j.tips.2022.08.005
https://doi.org/10.1016/j.tips.2022.08.005
Autor:
Eshan Ghosh, Hemlata Dwivedi, Mithu Baidya, Ashish Srivastava, Punita Kumari, Tomek Stepniewski, Hee Ryung Kim, Mi-Hye Lee, Jaana van Gastel, Madhu Chaturvedi, Debarati Roy, Shubhi Pandey, Jagannath Maharana, Ramon Guixà-González, Louis M. Luttrell, Ka Young Chung, Somnath Dutta, Jana Selent, Arun K. Shukla
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3287-3299.e6 (2019)
Summary: Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of sequence
Externí odkaz:
https://doaj.org/article/6c89aacecc9d4a92bef3658962de7d66
Autor:
Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Tamara Miljus, Shannon L. O’Brien, Tomasz M. Stepniewski, Brian Medel-Lacruz, Mithu Baidya, Maria Makarova, Ravi Mistry, Joëlle Goulding, Julia Drube, Carsten Hoffmann, Dylan M. Owen, Arun K. Shukla, Jana Selent, Stephen J. Hill, Davide Calebiro
Publikováno v:
Cell
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells remain elusive. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df63d5d439e67b15630e00bb403cf9c
https://europepmc.org/articles/PMC7614532/
https://europepmc.org/articles/PMC7614532/
Autor:
Jagannath Maharana, Parishmita Sarma, Manish K. Yadav, Sayantan Saha, Vinay Singh, Shirsha Saha, Mohamed Chami, Ramanuj Banerjee, Arun K. Shukla
Publikováno v:
Molecular Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b35e062810ec825572670d2fd57f545f
https://doi.org/10.1016/j.molcel.2023.04.025
https://doi.org/10.1016/j.molcel.2023.04.025
Autor:
Madhu Patial, Ruchi Chauhan, Harinder K. Chaudhary, Kallol K. Pramanick, Arun K. Shukla, Vishnu Kumar, Ramesh P. S. Verma
Publikováno v:
Critical Reviews in Biotechnology. 43:575-593
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ad047023873ba17fcad575678f80a4
https://doi.org/10.1080/07388551.2022.2050181
https://doi.org/10.1080/07388551.2022.2050181