Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Arun K, Shukla"'
Autor:
Manish K. Yadav, Parishmita Sarma, Jagannath Maharana, Manisankar Ganguly, Sudha Mishra, Nashrah Zaidi, Annu Dalal, Vinay Singh, Sayantan Saha, Gargi Mahajan, Saloni Sharma, Mohamed Chami, Ramanuj Banerjee, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The Hydroxycarboxylic acid receptor 2 (HCA2), also known as the niacin receptor or GPR109A, is a prototypical GPCR that plays a central role in the inhibition of lipolytic and atherogenic activities. Its activation also results in vasodilati
Externí odkaz:
https://doaj.org/article/81a025e0280946b39508480f0e82854e
Autor:
Parishmita Sarma, Carlo Marion C. Carino, Deeksha Seetharama, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Xue Rui, Yubo Cao, Kouki Kawakami, Poonam Kumari, Yu-Chih Chen, Kathryn E. Luker, Prem N. Yadav, Gary D. Luker, Stéphane A. Laporte, Xin Chen, Asuka Inoue, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms. Ligand promiscuity among these receptors makes them an interesting
Externí odkaz:
https://doaj.org/article/00c1bfe069ce44fd80ee66e1ab0d2340
Autor:
Khalid M. Alotaibi, Arun K. Shukla, Elham Bajuayfir, Abdullah A. Alotaibi, Mohamed H. Mrad, Fatma A. Gomaa, Abdullah M Alswieleh
Publikováno v:
Ultrasonics Sonochemistry, Vol 98, Iss , Pp 106497- (2023)
Contamination of heavy metal (Cd2+ & Pb2+) ions in drinking water is producing major impacts on the environment and public health and is considered one of the greatest dangers to humanity. Membrane technology has been chosen over other processing met
Externí odkaz:
https://doaj.org/article/ae688bcb2a77413084b5561a38943a95
Autor:
Mithu Baidya, Madhu Chaturvedi, Hemlata Dwivedi-Agnihotri, Ashutosh Ranjan, Dominic Devost, Yoon Namkung, Tomasz Maciej Stepniewski, Shubhi Pandey, Minakshi Baruah, Bhanupriya Panigrahi, Parishmita Sarma, Manish K. Yadav, Jagannath Maharana, Ramanuj Banerjee, Kouki Kawakami, Asuka Inoue, Jana Selent, Stéphane A. Laporte, Terence E. Hébert, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
G protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells.
Externí odkaz:
https://doaj.org/article/b914c159b8f9404cb1ff77ff55de3886
Autor:
Yutaro Shiraishi, Yutaka Kofuku, Takumi Ueda, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Arun K. Shukla, Ichio Shimada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
β-arrestins commonly bind to two distinct elements in GPCRs: the phosphorylated carboxyl terminal tail (C tail) and the cytoplasmic face of the transmembrane region (TM core). Here, the authors use methyl-TROSY NMR measurements to characterise the i
Externí odkaz:
https://doaj.org/article/c2744b4652694e1eb22b0a1f83faea09
Publikováno v:
Trends Pharmacol Sci
Atypical chemokine receptor subtype 3 (ACKR3), a chemokine receptor, couples selectively to β-arrestins (βarrs) but not to G proteins despite having seven transmembrane (7TM) helix architecture. Yen et al. present cryogenic-electron microscopy (cry
Autor:
Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Tamara Miljus, Shannon L. O’Brien, Tomasz M. Stepniewski, Brian Medel-Lacruz, Mithu Baidya, Maria Makarova, Ravi Mistry, Joëlle Goulding, Julia Drube, Carsten Hoffmann, Dylan M. Owen, Arun K. Shukla, Jana Selent, Stephen J. Hill, Davide Calebiro
Publikováno v:
Cell
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells remain elusive. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df63d5d439e67b15630e00bb403cf9c
https://europepmc.org/articles/PMC7614532/
https://europepmc.org/articles/PMC7614532/
Autor:
Jagannath Maharana, Parishmita Sarma, Manish K. Yadav, Sayantan Saha, Vinay Singh, Shirsha Saha, Mohamed Chami, Ramanuj Banerjee, Arun K. Shukla
Publikováno v:
Molecular Cell.
Autor:
Madhu Patial, Ruchi Chauhan, Harinder K. Chaudhary, Kallol K. Pramanick, Arun K. Shukla, Vishnu Kumar, Ramesh P. S. Verma
Publikováno v:
Critical Reviews in Biotechnology. 43:575-593
Autor:
Punita Kumari, Ashish Srivastava, Ramanuj Banerjee, Eshan Ghosh, Pragya Gupta, Ravi Ranjan, Xin Chen, Bhagyashri Gupta, Charu Gupta, Deepika Jaiman, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
β-arrestins initially contact with the phosphorylated carboxyl-terminus of GPCRs before engaging with the GPCR core. Here, the authors use a chimeric GPCR partially and fully engaged with β-arrestin1 and show that the core interaction is dispensabl
Externí odkaz:
https://doaj.org/article/b54ea5ad8c474cb084f9f6760eb12081