Zobrazeno 1 - 10
of 622
pro vyhledávání: '"Arun K, Ghosh"'
Autor:
Constantin Cretu, Patricia Gee, Xiang Liu, Anant Agrawal, Tuong-Vi Nguyen, Arun K. Ghosh, Andrew Cook, Melissa Jurica, Nicholas A. Larsen, Vladimir Pena
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recog
Externí odkaz:
https://doaj.org/article/9f060ae1a19640e593633f074975b41b
Autor:
Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when co
Externí odkaz:
https://doaj.org/article/86d3e81f7e794c15baedd9ad9a968412
Autor:
Arun K. Ghosh, Hao Yuan
Publikováno v:
Marine Drugs, Vol 20, Iss 10, p 587 (2022)
Iriomoteolide-1a and iriomoteolide-1b are very potent cytotoxic agents, isolated from marine dinoflagellates. We carried out the enantioselective syntheses of the proposed structures of these natural products. However, our analysis of the NMR spectra
Externí odkaz:
https://doaj.org/article/621636cac1d0463c952cf07a3edb397b
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258551 (2021)
U2 snRNP is an essential component of the spliceosome. It is responsible for branch point recognition in the spliceosome A-complex via base-pairing of U2 snRNA with an intron to form the branch helix. Small molecule inhibitors target the SF3B compone
Externí odkaz:
https://doaj.org/article/0976836617604d699a0dbbe03cebfff0
Autor:
Shin-ichiro Hattori, Nobuyo Higshi-Kuwata, Jakka Raghavaiah, Debananda Das, Haydar Bulut, David A. Davis, Yuki Takamatsu, Kouki Matsuda, Nobutoki Takamune, Naoki Kishimoto, Tadashi Okamura, Shogo Misumi, Robert Yarchoan, Kenji Maeda, Arun K. Ghosh, Hiroaki Mitsuya
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT We assessed various newly generated compounds that target the main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and various previously known compounds reportedly active against SARS-CoV-2, employing RNA qua
Externí odkaz:
https://doaj.org/article/6ecec4952e2541e4822a0d37047d8b35
Autor:
Andres Wong-Sam, Yuan-Fang Wang, Ying Zhang, Arun K. Ghosh, Robert W. Harrison, Irene T. Weber
Publikováno v:
ACS Omega, Vol 3, Iss 9, Pp 12132-12140 (2018)
Externí odkaz:
https://doaj.org/article/b0489614806d4cf1aec56db6622b7d47
Autor:
Arun K. Ghosh, Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J. Anson, Emma K. Lendy, Connie Bonham, Devika Sirohi, Carlos A. Brito-Sierra, Shin-ichiro Hattori, Richard Kuhn, Hiroaki Mitsuya, Andrew D. Mesecar
Publikováno v:
Molecules, Vol 26, Iss 19, p 5782 (2021)
We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synth
Externí odkaz:
https://doaj.org/article/f42c479ac437463dac472853373f2de5
Autor:
Nora S. Madaras, Michele L. Rankin, R. Benjamin Free, Raphael Haider, Julia Drube, Arun K. Ghosh, John JG. Tesmer, Carsten Hoffmann, David R. Sibley, Amy E. Moritz
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::792372b0e1657453be14dcd1424648fa
https://doi.org/10.1124/jpet.122.154110
https://doi.org/10.1124/jpet.122.154110
Autor:
Manabu Aoki, Debananda Das, Hironori Hayashi, Hiromi Aoki-Ogata, Yuki Takamatsu, Arun K. Ghosh, Hiroaki Mitsuya
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Darunavir (DRV) has bimodal activity against HIV-1 protease, enzymatic inhibition and protease dimerization inhibition, and has an extremely high genetic barrier against development of drug resistance. We previously generated a highly DRV-re
Externí odkaz:
https://doaj.org/article/ea1bc0f33022438aaa8ccaaea887a102
Publikováno v:
Chemical Communications. 58:11762-11782
We report our recent development of a conceptually new generation of exceptionally potent non-peptidic HIV-1 protease inhibitors that displayed excellent pharmacological and drug-resistance profiles. Our X-ray structural studies of darunavir and othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d17463ae610cedf2081b7f89547a09
https://doi.org/10.1039/d2cc04541a
https://doi.org/10.1039/d2cc04541a