Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Arun, Padmanabhan"'
Learn to build end-to-end AI apps from scratch for Android and iOS using TensorFlow Lite, CoreML, and PyTorchKey FeaturesBuild practical, real-world AI projects on Android and iOSImplement tasks such as recognizing handwritten digits, sentiment analy
Autor:
Austin Hsu, Qiming Duan, Daniel S. Day, Xin Luo, Sarah McMahon, Yu Huang, Zachary B. Feldman, Zhen Jiang, Tinghu Zhang, Yanke Liang, Michael Alexanian, Arun Padmanabhan, Jonathan D. Brown, Charles Y. Lin, Nathanael S. Gray, Richard A. Young, Benoit G. Bruneau, Saptarsi M. Haldar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In this study, Hsu et al. show that inhibition of CDK7/12/13 attenuates maladaptive transcriptional activation in cultured cardiomyocytes and a mouse model of heart failure, suggesting that targeting the transcription machinery might be a therapeutic
Externí odkaz:
https://doaj.org/article/88ec7013f71b476595a136b3ce75ccd1
Publikováno v:
Bio-Protocol, Vol 13, Iss 2 (2023)
Genome-wide CRISPR-based screening is a powerful tool in forward genetics, enabling biologic discovery by linking a desired phenotype to a specific genetic perturbation. However, hits from a genome-wide screen require individual validation to reprodu
Externí odkaz:
https://doaj.org/article/45183027d1e34f7d91b59b61ad96e564
Autor:
Lili Zhu, Krishna Choudhary, Barbara Gonzalez-Teran, Yen-Sin Ang, Reuben Thomas, Nicole R. Stone, Lei Liu, Ping Zhou, Chenchen Zhu, Hongmei Ruan, Yu Huang, Shibo Jin, Angelo Pelonero, Frances Koback, Arun Padmanabhan, Nandhini Sadagopan, Austin Hsu, Mauro W. Costa, Casey A. Gifford, Joke G. van Bemmel, Ruth Hüttenhain, Vasanth Vedantham, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Lars Steinmetz, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava
Publikováno v:
Circulation. 146(10)
Background: GATA4 (GATA-binding protein 4), a zinc finger–containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in this gene have been reported in human heart def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8933c6319a4274c2afbc510fa34f8fe
https://pubmed.ncbi.nlm.nih.gov/35938400
https://pubmed.ncbi.nlm.nih.gov/35938400
Autor:
Michael Alexanian, Arun Padmanabhan, Tomohiro Nishino, Joshua G. Travers, Lin Ye, Clara Youngna Lee, Nandhini Sadagopan, Yu Huang, Angelo Pelonero, Kirsten Auclair, Ada Zhu, Barbara Gonzalez Teran, Will Flanigan, Charis Kee-Seon Kim, Koya Lumbao-Conradson, Mauro Costa, Rajan Jain, Israel Charo, Saptarsi M. Haldar, Katherine S. Pollard, Ronald J. Vagnozzi, Timothy A. McKinsey, Pawel F. Przytycki, Deepak Srivastava
Chronic inflammation and tissue fibrosis are common stress responses that worsen organ function, yet the molecular mechanisms governing their crosstalk are poorly understood. In diseased organs, stress-induced changes in gene expression fuel maladapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce3f813f15b68d411cced6b1ab15fc02
https://doi.org/10.1101/2023.01.06.522937
https://doi.org/10.1101/2023.01.06.522937
Autor:
Tina A. Solvik, Alexandra M. Schnoes, Thi A. Nguyen, Shannon Behrman, Elie Maksoud, Sarah S. Goodwin, Ethan J. Weiss, Arun Padmanabhan, David N. Cornfield
ImportanceDespite the importance of clinician-scientists in propelling biomedical advances, the proportion of physicians engaged in both hypothesis-driven research and clinical care continues to decline. Recently, multiple institutions have developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6635efa5576297a78563b12c1990bf8d
https://doi.org/10.1101/2022.12.19.22283532
https://doi.org/10.1101/2022.12.19.22283532
Autor:
Geoffrey A. Smith, Arun Padmanabhan, Bryan H. Lau, Akhil Pampana, Li Li, Clara Y. Lee, Angelo Pelonero, Tomohiro Nishino, Nandhini Sadagopan, Vivian Q. Xia, Rajan Jain, Pradeep Natarajan, Roland S. Wu, Brian L. Black, Deepak Srivastava, Kevan M. Shokat, John S. Chorba
Publikováno v:
Sci Transl Med
The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States. We therefore sought to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1885a2e1fa6ddfcc35fee9491a35275
https://pubmed.ncbi.nlm.nih.gov/36103516
https://pubmed.ncbi.nlm.nih.gov/36103516
Publikováno v:
Circulation Research. 131
Fibrosis is a key feature of dilated cardiomyopathy (DCM). Stress signaling triggers the activation of quiescent fibroblasts to myofibroblasts. Bromodomain and extraterminal (BET) epigenetic reader proteins integrate stress-responsive signaling. We e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3221162a88eb035e6ec769de5843a16d
https://doi.org/10.1161/res.131.suppl_1.p2025
https://doi.org/10.1161/res.131.suppl_1.p2025
Autor:
Sanjeev S. Ranade, Sean Whalen, Ivana Zlatanova, Tomohiro Nishino, Benjamin van Soldt, Lin Ye, Angelo Pelonero, Langley Grace Wallace, Yu Huang, Michael Alexanian, Arun Padmanabhan, Barbara Gonzalez-Teran, Pawel Przytycki, Mauro W. Costa, Casey A. Gifford, Brian L. Black, Katherine S. Pollard, Deepak Srivastava
Communication between myriad cell types during organ formation underlies proper morphogenesis1. In cardiac development, reciprocal signaling between mesoderm progenitors and neural crest cells is essential, and its disruption leads to congenital hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::643e949c5df7fd1acbf53c7827855649
https://doi.org/10.1101/2022.07.25.501458
https://doi.org/10.1101/2022.07.25.501458
Autor:
Tomohiro Nishino, Sanjeev S. Ranade, Angelo Pelonero, Benjamin J. van Soldt, Lin Ye, Michael Alexanian, Frances Koback, Yu Huang, Nandhini Sadagopan, Arun Padmanabhan, Reuben Thomas, Joke G. van Bemmel, Casey A. Gifford, Mauro W. Costa, Deepak Srivastava
Birth defects occur in ∼6% of all live births and can be caused by combinations of genetic and environmental influences1. Large-scale DNA sequencing efforts are revealing genetic influences2,3, but investigations into the contributions of environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26eeef006b76c377d49dbc81b4817f1a
https://doi.org/10.1101/2022.07.25.501463
https://doi.org/10.1101/2022.07.25.501463