Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Arun, Chandramohan"'
Autor:
Katrine Ingelshed, Marit M. Melssen, Pavitra Kannan, Arun Chandramohan, Anthony W. Partridge, Long Jiang, Fredrik Wermeling, David P. Lane, Marika Nestor, Diana Spiegelberg
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109862- (2024)
Summary: Immunotherapy has revolutionized cancer treatment but its efficacy depends on a robust immune response in the tumor. Silencing of the tumor suppressor p53 is common in tumors and can affect the recruitment and activation of different immune
Externí odkaz:
https://doaj.org/article/a6f5c387d3ed4365a35bb503c9592eba
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro G. Aronica, Hung Yi Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Marika Nestor, Chandra S. Verma, David P. Lane, Tomi K. Sawyer, Robert Garbaccio, Brian Henry, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W. Johannes, Anthony W. Partridge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflo
Externí odkaz:
https://doaj.org/article/244b34e3aef44b508696598d0927724f
Autor:
Stephen H. Kasper, Stephanie Otten, Brian Squadroni, Cionna Orr‐Terry, Yi Kuang, Lily Mussallem, Lan Ge, Lin Yan, Srinivasaraghavan Kannan, Chandra S. Verma, Christopher J. Brown, Charles W. Johannes, David P. Lane, Arun Chandramohan, Anthony W. Partridge, Lee R. Roberts, Hubert Josien, Alex G. Therien, Erik C. Hett, Bonnie J. Howell, Andrea Peier, Xi Ai, Jason Cassaday
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 5, Pp n/a-n/a (2023)
Abstract Cyclic peptides are poised to target historically difficult to drug intracellular protein–protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have
Externí odkaz:
https://doaj.org/article/4ede5586001347c2a4d447e4b2a014ec
Autor:
Simon Ng, Shuhui Lim, Adrian Chong Nyi Sim, Ruban Mangadu, Ally Lau, Chunsheng Zhang, Sarah Bollinger Martinez, Arun Chandramohan, U-Ming Lim, Samantha Shu Wen Ho, Shih Chieh Chang, Pooja Gopal, Lewis Z. Hong, Adam Schwaid, Aaron Zefrin Fernandis, Andrey Loboda, Cai Li, Uyen Phan, Brian Henry, Anthony W. Partridge
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identify tumour-intrinsic mechanisms un
Externí odkaz:
https://doaj.org/article/0fbf12d4ecc444c2912ab9c47b00b517
Autor:
Xin-Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee-Mei Lok, Ganesh S. Anand
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Temperature differences between mosquitoes and humans trigger structural changes in dengue virus 2 (DENV2) particles, but not in other DENV serotypes. Here, using HDXMS, the authors describe serotype-specific expansion of intact viral particles of DE
Externí odkaz:
https://doaj.org/article/d34d5ae0dd4f44a88618484220093aef
Autor:
Kiran Mohan, V. Madhusudanan Pillai, Pujara Dhaval Jayendrakumar, Praveen Sankaran, Arun Chandramohan
Publikováno v:
Theoretical Issues in Ergonomics Science. 23:749-769
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dd2b138e4b145f14652bf4db9d1cae7
https://doi.org/10.1080/1463922x.2022.2036860
https://doi.org/10.1080/1463922x.2022.2036860
Autor:
null Stephen H. Kasper, null Stephanie Otten, null Brian Squadroni, null Cionna Orr‐Terry, null Yi Kuang, null Lily Mussallem, null Lan Ge, null Lin Yan, null Srinivasaraghavan Kannan, null Chandra S. Verma, null Christopher J. Brown, null Charles W. Johannes, null David P. Lane, null Arun Chandramohan, null Anthony W. Partridge, null Lee R. Roberts, null Hubert Josien, null Alex G. Therien, null Erik C. Hett, null Bonnie J. Howell, null Andrea Peier, null Xi Ai, null Jason Cassaday
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a3660365f9c9945a524ebfb3f98bc0
https://doi.org/10.1002/btm2.10542/v2/response1
https://doi.org/10.1002/btm2.10542/v2/response1
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro Aronica, Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Brian Henry, Marika Nestor, Chandra S Verma, David Lane, Tomi Sawyer, Robert Garbaccio, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W Johannes, Anthony William Partridge
Stapled α-helical peptides can bind to and modulate historically intractable targets while addressing the traditional liabilities associated with peptide therapeutics. However, their pipeline advancement has been impeded by the challenges of identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80f15998d22633b086d54b5c6b03932d
https://doi.org/10.1101/2023.02.25.530030
https://doi.org/10.1101/2023.02.25.530030
Autor:
Charles W. Johannes, Dawn Thean, Joe R Cannon, Raymond Evers, Tanvi Desai, Hung Yi Kristal Kaan, David P. Lane, Christopher J. Brown, Ahmad Sadruddin, Anthony W. Partridge, Tsz Ying Yuen, Arun Chandramohan, Tomi K. Sawyer, Jerome Hochman, Bahanu Habulihaz
Publikováno v:
Pharmaceutical Research. 38:843-850
To develop a novel, target agnostic liposome click membrane permeability assay (LCMPA) using liposome encapsulating copper free click reagent dibenzo cyclooctyne biotin (DBCO-Biotin) to conjugate azido modified peptides that may effectively transloca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85323783776f557af1a6d5fc227af5b3
https://doi.org/10.1007/s11095-021-03005-z
https://doi.org/10.1007/s11095-021-03005-z
Autor:
Arun Chandramohan, Srinath Krishnamurthy, Andreas Larsson, Paer Nordlund, Anna Jansson, Ganesh S Anand
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 6, p e1004840 (2016)
A key question in mapping dynamics of protein-ligand interactions is to distinguish changes at binding sites from those associated with long range conformational changes upon binding at distal sites. This assumes a greater challenge when considering
Externí odkaz:
https://doaj.org/article/2cb35911c5d84ef280f67288fdfc2226