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Targeting the cyclin-binding groove site to inhibit the catalytic activity of CDK2/cyclin A complex using p27KIP1-derived peptidomimetic inhibitors

Autor: Venkatesan Suryanarayanan, Ramasamy Shanmugam, Sunil Kumar Tripathi, Sanjeev Kumar Singh, Arumugasamy Karthiga

Publikováno v: Journal of Chemical Biology. 8:11-24

Functionally activated cyclin-dependent kinase 2 (CDK2)/cyclin A complex has been validated as an interesting therapeutic target to develop the efficient antineoplastic drug based on the cell cycle arrest. Cyclin A binds to CDK2 and activates the kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f9aaf1337668e1b62e6ad51392fabe
https://doi.org/10.1007/s12154-014-0124-y

A three-dimensional chemical phase pharmacophore mapping, QSAR modelling and electronic feature analysis of benzofuran salicylic acid derivatives as LYP inhibitors

Autor: Chandrabose Selvaraj, Arumugasamy Karthiga, S Kumar Singh, Venkatesan Suryanarayanan, K Konda Reddy, S Kumar Tripathi

Publikováno v: SAR and QSAR in environmental research. 24(12)

Lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, has a critical negative regulatory role in T-cell antigen receptor (TCR) and emerged as a promising drug target for human autoimmune diseases. A five-point pharmacophore with two hydrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a277c9b9a1e9a751afd41f1870e61d7a
https://pubmed.ncbi.nlm.nih.gov/23987088

Synthesis, antibacterial studies, and molecular modeling studies of 3,4-dihydropyrimidinone compounds.

Autor: Ramachandran, Vanitha, Arumugasamy, Karthiga, Singh, Sanjeev, Edayadulla, Naushad, Ramesh, Penugonda, Kamaraj, Sathish-Kumar

Publikováno v: Journal of Chemical Biology; Jan2016, Vol. 9 Issue 1, p31-40, 10p

Synthesis, antibacterial studies, and molecular modeling studies of 3,4-dihydropyrimidinone compounds.

Autor: Ramachandran V; Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, 625021 Tamil Nadu India., Arumugasamy K; Department of Zoology, Thiagarajar College, Madurai, 625009 Tamil Nadu India., Singh SK; Computer Aided Drug Designing and Molecular Modeling Laboratory, Department of Bioinformatics, Alagappa University, Karaikudi, 630 003 Tamil Nadu India., Edayadulla N; School of Chemical Engineering, Yeungnam University, Gyeongsan, 712-749 Republic of Korea., Ramesh P; Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, 625021 Tamil Nadu India., Kamaraj SK; Ingeniería en Energía, Universidad Politécnica de Aguascalientes, Calle Paseo San Gerardo No. 207. Fracc. San Gerardo, Aguascalientes, AGS Mexico 20342.

Publikováno v: Journal of chemical biology [J Chem Biol] 2015 Jul 04; Vol. 9 (1), pp. 31-40. Date of Electronic Publication: 2015 Jul 04 (Print Publication: 2016).