Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.

Autor: Goswami R; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Wohlfahrt G; Orion Corporation, Orionintie 1, FIN-02101 Espoo, Finland., Törmäkangas O; Orion Corporation, Tengströminkatu 8, FIN-20101 Turku, Finland., Moilanen A; Orion Corporation, Tengströminkatu 8, FIN-20101 Turku, Finland., Lakshminarasimhan A; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Nagaraj J; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Arumugam KN; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Mukherjee S; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Chacko AR; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Krishnamurthy NR; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Jaleel M; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Palakurthy RK; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Samiulla DS; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India., Ramachandra M; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India. Electronic address: murali_r@aurigene.com.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5309-14. Date of Electronic Publication: 2015 Sep 21.

Design and synthesis of newer N-benzimidazol-2yl benzamide analogues as allosteric activators of human glucokinase.

Autor: Singh, Sukhbir, Arora, Sandeep, Dhalio, Ervon, Sharma, Neelam, Arora, Kunal, Grewal, Ajmer Singh

Publikováno v: Medicinal Chemistry Research; Mar2021, Vol. 30 Issue 3, p760-770, 11p