Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Arumay Pal"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Protein-DNA interactions play a crucial role in gene expression and regulation. Identifying the DNA binding surface of proteins has long been a challenge–in comparison to protein-protein interactions, limited progress has been made in the developme
Externí odkaz:
https://doaj.org/article/0756ed9181834f42babda582356140c7
Autor:
Arumay Pal, Yaakov Levy
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007867 (2020)
DNA sequences are often recognized by multi-domain proteins that may have higher affinity and specificity than single-domain proteins. However, the higher affinity to DNA might be coupled with slower recognition kinetics. In this study, we address th
Externí odkaz:
https://doaj.org/article/5fc69e5e218b44c786157210ac1678f5
Autor:
Arumay Pal, Yaakov Levy
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006768 (2019)
Recognition of single-stranded DNA (ssDNA) or single-stranded RNA (ssRNA) is important for many fundamental cellular functions. A variety of single-stranded DNA-binding proteins (ssDBPs) and single-stranded RNA-binding proteins (ssRBPs) have evolved
Externí odkaz:
https://doaj.org/article/f8b6d23313364ba6b77bf0bae9b77f1e
Publikováno v:
Biochemistry
DNA mismatch repair (MMR) is an important postreplication process that eliminates mispaired or unpaired nucleotides to ensure genomic replication fidelity. In humans, Msh2-Msh6 and Msh2-Msh3 are the two mismatch repair initiation factors that recogni
Autor:
Kurt Neo, Arumay Pal, David P. Lane, Lakshminarayanan Rajamani, Fernando J. Ferrer, Chandra S. Verma, Alessandra Mortellaro
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Interleukin-1β (IL-1β) is a major cytokine that initiates and enhances inflammatory responses. Excessive IL-1β production is a characteristic of most chronic inflammatory diseases, including atherosclerosis, type 2 diabetes, and obesity, which aff
Publikováno v:
Molecular BioSystems. 13:2697-2703
In prokaryotes, the RecA protein catalyzes the repair and strand exchange of double-stranded DNA. RecA binds to single-stranded DNA (ssDNA) and forms a presynaptic complex in which the protein polymerizes around the ssDNA to form a right-handed helic
Autor:
Srinivasaraghavan Kannan, Arumay Pal, Matthew Nguyen, Yaw Sing Tan, Stephen J. Fox, Jianguo Li, Zahra Ouaray, Shilpa Yadahalli
Publikováno v:
Current Pharmaceutical Design. 22:3585-3600
Discovery of new therapeutics is a very challenging, expensive and time-consuming process. With the number of approved drugs declining steadily, combined with increasing costs, a rational approach is needed to facilitate, expedite and streamline the
Autor:
Kwoh Chee Keong, Arumay Pal, Chandra S. Verma, Zhongqiao Hu, Srinivasaraghavan Kannan, David P. Lane, Mohan R. Pradhan
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:254-266
Aggregation is an irreversible form of protein complexation and often toxic to cells. The process entails partial or major unfolding that is largely driven by hydration. We model the role of hydration in aggregation using "Dehydrons." "Dehydrons" are
Publikováno v:
Biochemistry; 12/29/2020, Vol. 59 Issue 51, p4822-4832, 11p
Publikováno v:
Nucleic Acids Research
We present a set of four parameters that in combination can predict DNA-binding residues on protein structures to a high degree of accuracy. These are the number of evolutionary conserved residues (N(cons)) and their spatial clustering (ρ(e)), hydro