Integrating c-Met molecular imaging into the optimisation of cancer therapy

Autor: Arulappu, Appitha

Basal-like subtypes of breast cancer (BLBC) account for about 15-20% of all breast cancer, affecting younger women

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.700783

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

Autor: James Monypenny, Hanna Milewicz, Fabian Flores-Borja, Gregory Weitsman, Anthony Cheung, Ruhe Chowdhury, Thomas Burgoyne, Appitha Arulappu, Katherine Lawler, Paul R. Barber, Jose M. Vicencio, Melanie Keppler, Wahyu Wulaningsih, Sean M. Davidson, Franca Fraternali, Natalie Woodman, Mark Turmaine, Cheryl Gillett, Dafne Franz, Sergio A. Quezada, Clare E. Futter, Alex Von Kriegsheim, Walter Kolch, Borivoj Vojnovic, Jeremy G. Carlton, Tony Ng

Publikováno v: Cell Reports, Vol 24, Iss 3, Pp 630-641 (2018)

Summary: The immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA screen identified the endosomal sorting complexes required for transport (ESCRT)-as

Externí odkaz: https://doaj.org/article/271d76a1d4d644ff8f8a80c533ecdc3e

The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.

Autor: Richard Beatson, Gjertrud Maurstad, Gianfranco Picco, Appitha Arulappu, Julia Coleman, Hans H Wandell, Henrik Clausen, Ulla Mandel, Joyce Taylor-Papadimitriou, Marit Sletmoen, Joy M Burchell

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0125994 (2015)

Aberrant glycosylation occurs in the majority of human cancers and changes in mucin-type O-glycosylation are key events that play a role in the induction of invasion and metastases. These changes generate novel cancer-specific glyco-antigens that can

Externí odkaz: https://doaj.org/article/ba071af7f77445f1bf0b642c2efabb36

c-Met PET Imaging Detects Early-Stage Locoregional Recurrence of Basal-Like Breast Cancer

Autor: Michel Eisenblaetter, Gregory Weitsman, Mark Battle, Imtiaz Khan, Grethe Tang Dalsgaard, Graeme McRobbie, Susan Hoppmann, James Monypenny, Patrycja Gazinska, Wulan Wulaningsih, Appitha Arulappu, Sven Macholl, Myria Galazi, Tony Ng

Publikováno v: Arulappu, A, Battle, M, Eisenblaetter, M, McRobbie, G, Khan, I, Monypenny, J, Weitsman, G, Galazi, M, Hoppmann, S, Gazinska, P, Wulaningsih, W, Dalsgaard, G T, Macholl, S & Ng, T 2016, ' c-Met PET Imaging Detects Early-Stage Locoregional Recurrence of Basal-Like Breast Cancer ', Journal of Nuclear Medicine, vol. 57, no. 5, pp. 765-70 . https://doi.org/10.2967/jnumed.115.164384

Locoregional recurrence of breast cancer poses significant clinical problems because of frequent inoperability once the chest wall is involved. Early detection of recurrence by molecular imaging agents against therapeutically targetable receptors, su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ba65608d2f30e0dcba5b0259331c0a
https://doi.org/10.2967/jnumed.115.164384

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