Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Arul J. Duraisamy"'
Mucopolysaccharidosis Type I Presenting with Persistent Neonatal Respiratory Distress: A Case Report
Autor:
Ali Alsuheel Asseri, Ahmad Alzoani, Abdulwahab M. Almazkary, Nisreen Abdulaziz, Mufareh H. Almazkary, Samy Ailan Alahmari, Arul J. Duraisamy, Shruti Sureshkumar
Publikováno v:
Diseases, Vol 11, Iss 2, p 67 (2023)
Mucopolysaccharidosis type I (MPS I) is a rare inherited autosomal recessive lysosomal storage disorder. Despite several reports on MPS I-related neonatal interstitial lung disease, it is still considered to be an under-recognized disease manifestati
Externí odkaz:
https://doaj.org/article/e802cf3140bc437fbcd8b482146fbd17
Publikováno v:
Mol Neurobiol
Early activation of cytosolic NADPH oxidase-2 (Nox2) in diabetes increases retinal ROS production, damaging their mitochondria. The assembly of Nox2 holoenzyme requires activation of a small molecular weight G protein Rac1. Rac1 activation is regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c46660848143e9665045cc214f69e17
https://doi.org/10.1007/s12035-019-01696-5
https://doi.org/10.1007/s12035-019-01696-5
Publikováno v:
Antioxid Redox Signal
Aims: Diabetes increases oxidative stress in the retina and dysfunctions their mitochondria, accelerating capillary cell apoptosis. A 66 kDa adaptor protein, p66Shc, is considered as a sensor of oxidative stress-induced apoptosis. In the pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2003652d9cdfb858725a778176b31a1
https://doi.org/10.1089/ars.2018.7542
https://doi.org/10.1089/ars.2018.7542
Publikováno v:
Diabetes
Diabetic retinopathy is a multifactorial disease, and the exact mechanism of its pathogenesis remains obscure. Sirtuin 1 (Sirt1), a multifunctional deacetylase, is implicated in the regulation of many cellular functions and in gene transcription, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3177f469633d549a63961bfcd379c163
https://doi.org/10.2337/db17-0996
https://doi.org/10.2337/db17-0996
Publikováno v:
Translational Vision Science & Technology
Purpose Progression of diabetic retinopathy is related to the duration and severity of hyperglycemia, and after 25 years of diabetes, 90% of patients show some signs of retinopathy. Despite initiation of many retinal molecular/biochemical abnormaliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78c7fbb70a142b4de8825dbecee21e3
https://pubmed.ncbi.nlm.nih.gov/31871829
https://pubmed.ncbi.nlm.nih.gov/31871829
Eyes are one of the most complex organs in our body; the sense of sight is the most appreciated senses and 90% of all information is acquired through vision. However, eyes are constantly exposed to the environmental factors like pollutants, bacteria,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a487f7a973bd453c83a7eecdeb0a73d
https://doi.org/10.1016/b978-0-12-814259-2.00006-6
https://doi.org/10.1016/b978-0-12-814259-2.00006-6
Autor:
Osama Aazmi, Maryam Akhtari, Ramchandra V. Amnekar, Eralda Asllanaj, Jesús Beltrán-García, Sudarshan Bhattacharjee, Shilpa Bisht, Priyanka Chaurasia, Ana B. Crujeiras, Rima Dada, Jean-François Deleuze, Arul J. Duraisamy, Elham Farhadi, Oscar H. Franco, José Luis García-Giménez, Marija Glisic, Ansh Goswami, Caleb Grote, Sanjay Gupta, Andrea G. Izquierdo, Rakesh Mohan Jha, Ananthamohan Kalyani, Abhishek Kanyal, Krishanpal Karmodiya, Saima Khan, Renu A. Kowluru, Mohamad M. Kronfol, Mahdi Mahmoudi, Florence Mauger, Joseph L. McClay, Salvador Mena-Mollá, Manish Mishra, Taulant Muka, Sunil Nahata, Jana Nano, Abhiram Natu, Carolina Ochoa-Rosales, Gisselle Pérez-Machado, Carlos Romá-Mateo, Marta Seco-Cervera, Asmita Sharda, Shilpy Sharma, null Sukanya, Jinxi Wang, Mingcai Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6698fd76a1705c2fc522c748eb6540b
https://doi.org/10.1016/b978-0-12-814259-2.09996-9
https://doi.org/10.1016/b978-0-12-814259-2.09996-9
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1865(6)
Mitochondria are dynamic in structure, and undergo continuous fusion-fission to maintain their homeostasis. In diabetes, retinal mitochondria are swollen, their membrane is damaged and mitochondrial fusion protein, mitofusin 2 (Mfn2), is decreased. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45587a01271fde89fb489f7cd0b4e395
https://pubmed.ncbi.nlm.nih.gov/30922813
https://pubmed.ncbi.nlm.nih.gov/30922813
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Oxidative stress plays a central role in the development of diabetic retinopathy, and in the pathogenesis of this blinding disease, activation of NADPH oxidase 2 (Nox2)-mediated cytosolic reactive oxygen species (ROS) production precedes mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae5a8a3cf4e352278b9b2a095cc3eef
https://pubmed.ncbi.nlm.nih.gov/30347077
https://pubmed.ncbi.nlm.nih.gov/30347077
Autor:
Rajesh Arora, Murugesan Balamurugan, Anuja Bhardwaj, Jonathan C. Claussen, Arul J. Duraisamy, Shefali Gola, Chandran Karunakaran, Deepti Majumdar, Preenon Majumdar, Dhurjati Majumdar, Manimaran Manickam, Jigni Mishra, Kshipra Misra, Mamta Pal, Syed Rahamathulla, null Rakhee, Paulraj Santharaman, Priyanka Sharma, Raj K. Sharma, Sushil Kumar Singh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c489fb6ffe668a223c36b81fd0eaa713
https://doi.org/10.1016/b978-0-12-813999-8.09988-2
https://doi.org/10.1016/b978-0-12-813999-8.09988-2