Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Arul, Jayaraman"'
Autor:
Yufang Ding, Karin Yanagi, Fang Yang, Evelyn Callaway, Clint Cheng, Martha E Hensel, Rani Menon, Robert C Alaniz, Kyongbum Lee, Arul Jayaraman
Publikováno v:
eLife, Vol 12 (2024)
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the pathology
Externí odkaz:
https://doaj.org/article/6d70f0c97fff4de2be699b435e2b8fe6
Autor:
Jugal Kishore Das, Fengguang Guo, Carrie Hunt, Shelby Steinmeyer, Julia A Plocica, Koichi S. Kobayashi, Yufang Ding, Arul Jayaraman, Thomas A Ficht, Robert C. Alaniz, Paul de Figueiredo, Jianxun Song
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Immunotherapy has led to impressive advances in the treatment of autoimmune and pro-inflammatory disorders; yet, its clinical outcomes remain limited by a variety of factors including the pro-inflammatory microenvironment (IME). Discovering effective
Externí odkaz:
https://doaj.org/article/b23a1d9e8ee941c29942432317185d80
Autor:
Fang Yang, Jennifer A. A. DeLuca, Rani Menon, Erika Garcia-Vilarato, Evelyn Callaway, Kerstin K. Landrock, Kyongbum Lee, Stephen H. Safe, Robert S. Chapkin, Clinton D. Allred, Arul Jayaraman
Publikováno v:
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-18 (2020)
Abstract Background Diet, loss of aryl hydrocarbon receptor (AhR) expression and their modification of the gut microbiota community composition and its metabolites affect the development of colorectal cancer (CRC). However, the concordance between fe
Externí odkaz:
https://doaj.org/article/aaf9ba958d8247db905e79e165fc8578
Autor:
Ying-Shiuan Chen, Jia Li, Rani Menon, Arul Jayaraman, Kyongbum Lee, Yun Huang, Wan Mohaiza Dashwood, Ke Zhang, Deqiang Sun, Roderick H. Dashwood
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Complex interrelationships govern the dynamic interactions between gut microbes, the host, and exogenous drivers of disease outcome. A multi-omics approach to cancer prevention by spinach (SPI) was pursued for the first time in the polyposis in rat c
Externí odkaz:
https://doaj.org/article/76e97d7c0ea941a581106fe7cc541f54
Autor:
Stephen Safe, Huajun Han, Arul Jayaraman, Laurie A. Davidson, Clinton D. Allred, Ivan Ivanov, Yongjian Yang, James J. Cai, Robert S. Chapkin
Publikováno v:
Receptors. 2:93-99
The aryl hydrocarbon receptor (AhR) is overexpressed in many tumor types and exhibits tumor-specific tumor promoter and tumor suppressor-like activity. In colon cancer, most but not all studies suggest that the AhR exhibits tumor suppressor activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd787fe9baf116b8e8379d8980c32763
https://doi.org/10.3390/receptors2010005
https://doi.org/10.3390/receptors2010005
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008472 (2020)
Developing an accurate first-principle model is an important step in employing systems biology approaches to analyze an intracellular signaling pathway. However, an accurate first-principle model is difficult to be developed since it requires in-dept
Externí odkaz:
https://doaj.org/article/51308e5df62a46df978b0c7d2300eaee
Autor:
Ying-Shiuan Chen, Jia Li, Sultan Neja, Sabeeta Kapoor, Jorge Enrique Tovar Perez, Chakrapani Tripathi, Rani Menon, Arul Jayaraman, Kyongbum Lee, Wan Mohaiza Dashwood, Shan Wang, Ke Zhang, Koichi Kobayashi, Praveen Rajendran, Roderick Dashwood
Publikováno v:
Cells, Vol 11, Iss 3, p 573 (2022)
There is growing interest in the crosstalk between the gut microbiome, host metabolomic features, and disease pathogenesis. The current investigation compared long–term (26 week) and acute (3 day) dietary spinach intake in a genetic model of colore
Externí odkaz:
https://doaj.org/article/f51a7056465e42d39ee41ebee6852c43
Autor:
Smitha Krishnan, Yufang Ding, Nima Saedi, Maria Choi, Gautham V. Sridharan, David H. Sherr, Martin L. Yarmush, Robert C. Alaniz, Arul Jayaraman, Kyongbum Lee
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1099-1111 (2018)
Summary: The gut microbiota plays a significant role in the progression of fatty liver disease; however, the mediators and their mechanisms remain to be elucidated. Comparing metabolite profile differences between germ-free and conventionally raised
Externí odkaz:
https://doaj.org/article/b605879bd89849c7a6e05d6bee4c7e7c
Autor:
Caitlin A, Madison, Roanna A, Debler, Nathan I, Vardeleon, Lauren, Hillbrick, Arul, Jayaraman, Stephen, Safe, Robert S, Chapkin, Shoshana, Eitan
Publikováno v:
Journal of Affective Disorders. 319:213-220
Our recent study demonstrated that selective aryl hydrocarbon receptor modulators (SAhRMs), such as 1,4-dihydroxy-2-napthoic acid (DHNA) act as antidepressants in female mice. Given that some effects of certain SAhRMs are known to also be mediated vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec61d6eaf79d71817a4563a9866047a2
https://doi.org/10.1016/j.jad.2022.09.155
https://doi.org/10.1016/j.jad.2022.09.155
Autor:
Gaurav Baranwal, Rachel Pilla, Bethany L. Goodlett, Aja K. Coleman, Cristina M. Arenaz, Arul Jayaraman, Joseph M. Rutkowski, Robert C. Alaniz, Brett M. Mitchell
Publikováno v:
Biomolecules, Vol 11, Iss 9, p 1387 (2021)
Recent metabolomics studies have identified a wide array of microbial metabolites and metabolite pathways that are significantly altered in hypertension. However, whether these metabolites play an active role in pathogenesis of hypertension or are al
Externí odkaz:
https://doaj.org/article/d3f59cd65e204742b5224d032e2630ae