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pro vyhledávání: '"Arukuusk P"'
Autor:
Heleri H. Härk, Ly Porosk, Lucas R. de Mello, Piret Arukuusk, Emerson R. da Silva, Kaido Kurrikoff
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 883 (2023)
Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors. We have previously shown th
Externí odkaz:
https://doaj.org/article/65a520ddd5894e35a3305242e27194e6
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 952 (2023)
mRNA-based therapeutics are presently one of the nucleic acid-based therapeutics with a high potential for extraordinary success as preventive vaccines. Current applications with mRNA therapeutics rely on lipid nanoparticle (LNP) mediated delivery of
Externí odkaz:
https://doaj.org/article/288cfc8152c14aedae77b5a6ca3bd054
Autor:
Ly Porosk, Heleri Heike Härk, Renata Naporano Bicev, Ilja Gaidutšik, Jekaterina Nebogatova, Eger-Jasper Armolik, Piret Arukuusk, Emerson Rodrigo da Silva, Ülo Langel
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4277 (2023)
Alzheimer’s disease (AD) is the most common neurodegenerative disease (ND) and the leading cause of dementia. It is characterized by non-linear, genetic-driven pathophysiological dynamics with high heterogeneity in the biological alterations and th
Externí odkaz:
https://doaj.org/article/ed256885bc9c4fb4816c4a2af3311084
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Peptides can be used as research tools and for diagnostic or therapeutic applications. Peptides, alongside small molecules and antibodies, are used and are gaining further interest as protein-protein interaction (PPI) modulators. Peptides have high t
Externí odkaz:
https://doaj.org/article/ea46b59029c84d31b93f53ec1e782af9
Autor:
Ly Porosk, Jekaterina Nebogatova, Heleri Heike Härk, Birgit Vunk, Piret Arukuusk, Urve Toots, Mart Ustav, Ülo Langel, Kaido Kurrikoff
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1949 (2022)
Therapeutic proteins are currently at the apex of innovation in pharmaceutical medicine. However, their industrial production is technically challenging and improved methods for transient transfection of mammalian cell cultures are necessary. We aime
Externí odkaz:
https://doaj.org/article/c4dfbd138aa549bfabe4815d0ae62279
Autor:
Krista Freimann, Piret Arukuusk, Kaido Kurrikoff, Ly Pärnaste, Raivo Raid, Andres Piirsoo, Margus Pooga, Ülo Langel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 28-35 (2018)
Although advances in genomics and experimental gene therapy have opened new possibilities for treating otherwise incurable diseases, the transduction of nucleic acids into the cells and delivery in vivo remain challenging. The high molecular weight a
Externí odkaz:
https://doaj.org/article/68577712943243b5ade7880decde107e
Autor:
Kristina Kiisholts, Kaido Kurrikoff, Piret Arukuusk, Ly Porosk, Maire Peters, Andres Salumets, Ülo Langel
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1618 (2021)
Gene therapy is a powerful tool for the development of new treatment strategies for various conditions, by aiming to transport biologically active nucleic acids into diseased cells. To achieve that goal, we used highly potential delivery vectors, cel
Externí odkaz:
https://doaj.org/article/a00e316b06fd4bc7a070b41e6c7676bb
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 1-10 (2017)
Cell-penetrating peptides (CPPs) are delivery vectors widely used to aid the transport of biologically active cargoes to intracellular targets. These cargoes include small interfering RNAs (siRNA) that are not naturally internalized by cells. Elucida
Externí odkaz:
https://doaj.org/article/c636e91473d24e1da28266ff8dc57f43
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