Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Arturo Ortín-Martínez"'
Autor:
Akshay Gurdita, Philip E.B. Nickerson, Neno T. Pokrajac, Arturo Ortín-Martínez, En Leh Samuel Tsai, Lacrimioara Comanita, Nicole E. Yan, Parnian Dolati, Nobuhiko Tachibana, Zhongda C. Liu, Joel D. Pearson, Danian Chen, Rod Bremner, Valerie A. Wallace
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102905- (2021)
Summary: The mouse eye is used to model central nervous system development, pathology, angiogenesis, tumorigenesis, and regenerative therapies. To facilitate the analysis of these processes, we developed an optimized tissue clearing and depigmentatio
Externí odkaz:
https://doaj.org/article/690639e28fdf4887a49aa43056db11a4
Autor:
Juan A. Miralles de Imperial-Ollero, Alejandro Gallego-Ortega, Arturo Ortín-Martínez, María Paz Villegas-Pérez, Francisco J. Valiente-Soriano, Manuel Vidal-Sanz
Publikováno v:
Life, Vol 11, Iss 11, p 1137 (2021)
Phototoxicity animal models have been largely studied due to their degenerative communalities with human pathologies, e.g., age-related macular degeneration (AMD). Studies have documented not only the effects of white light exposure, but also other w
Externí odkaz:
https://doaj.org/article/85fbaeda6b8a4df690cd2c8ca497a1b3
Autor:
Francisco J. Valiente-Soriano, Johnny Di Pierdomenico, Diego García-Ayuso, Arturo Ortín-Martínez, Juan A. Miralles de Imperial-Ollero, Alejandro Gallego-Ortega, Manuel Jiménez-López, M. Paz Villegas-Pérez, S. Patricia Becerra, Manuel Vidal-Sanz
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7242 (2020)
Here, we evaluated the effects of PEDF (pigment epithelium-derived factor) and PEDF peptides on cone-photoreceptor cell damage in a mouse model of focal LED-induced phototoxicity (LIP) in vivo. Swiss mice were dark-adapted overnight, anesthetized, an
Externí odkaz:
https://doaj.org/article/14d8854cb6be4b76a46297690ee53f5d
Autor:
Beatriz Vidal-Villegas, Johnny Di Pierdomenico, Juan A Miralles de Imperial-Ollero, Arturo Ortín-Martínez, Francisco M Nadal-Nicolás, Jose M Bernal-Garro, Nicolás Cuenca Navarro, María P Villegas-Pérez, Manuel Vidal-Sanz
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3012 (2019)
We studied short- and long-term effects of intravitreal injection of N-methyl-d-aspartate (NMDA) on melanopsin-containing (m+) and non-melanopsin-containing (Brn3a+) retinal ganglion cells (RGCs). In adult SD-rats, the left eye received a single intr
Externí odkaz:
https://doaj.org/article/7509bc38965e40a093453a12b70b8997
Autor:
Francisco J Valiente-Soriano, Manuel Salinas-Navarro, Manuel Jiménez-López, Luis Alarcón-Martínez, Arturo Ortín-Martínez, José M Bernal-Garro, Marcelino Avilés-Trigueros, Marta Agudo-Barriuso, María P Villegas-Pérez, Manuel Vidal-Sanz
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121134 (2015)
To study the effects of ocular hypertension (OHT) on the visual system of C57BL/6 pigmented mice, the limbal and episcleral veins of the left eye were laser photocoagulated (LP). LP increased the intraocular pressure during the first five days (d), r
Externí odkaz:
https://doaj.org/article/18a0d70b32294c26a4bdcedf4365481c
Autor:
Arturo Ortín-Martínez, Francisco M Nadal-Nicolás, Manuel Jiménez-López, Juan J Alburquerque-Béjar, Leticia Nieto-López, Diego García-Ayuso, Maria P Villegas-Pérez, Manuel Vidal-Sanz, Marta Agudo-Barriuso
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102392 (2014)
We purpose here to analyze and compare the population and topography of cone photoreceptors in two mouse strains using automated routines, and to design a method of retinal sampling for their accurate manual quantification. In whole-mounted retinas f
Externí odkaz:
https://doaj.org/article/be92a8d8aebb42d19e055961e801a901
Autor:
Arturo Ortín-Martínez, Francisco Javier Valiente-Soriano, Diego García-Ayuso, Luis Alarcón-Martínez, Manuel Jiménez-López, José Manuel Bernal-Garro, Leticia Nieto-López, Francisco Manuel Nadal-Nicolás, María Paz Villegas-Pérez, Larry A Wheeler, Manuel Vidal-Sanz
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113798 (2014)
We have investigated the effects of light-emitting diode (LED)-induced phototoxicity (LIP) on cone-photoreceptors and their protection with brimonidine (BMD), brain-derived neurotrophic factor (BDNF), pigment epithelium-derived factor (PEDF), ciliary
Externí odkaz:
https://doaj.org/article/9b5e6c8a76f34663b92c335d51fa64c5
Autor:
Kenneth Aldape, Valerie A. Wallace, Nicole I. Park, Ahmed El-Sehemy, Katherine J. Rowland, Peter B. Dirks, Lilian Lee, Neno T Pokrajac, Yasin Mamatjan, Hayden J. Selvadurai, Arturo Ortín-Martínez, Nobuhiko Tachibana
Publikováno v:
Journal of Clinical Investigation. 130:3069-3086
Glioblastoma multiforme (GBM) contains a subpopulation of cells, GBM stem cells (GSCs), that maintain the bulk tumor and represent a key therapeutic target. Norrin is a Wnt ligand that binds Frizzled class receptor 4 (FZD4) to activate canonical Wnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2662391750bad794a6cb43f049ad04
https://doi.org/10.1172/jci128994
https://doi.org/10.1172/jci128994
Autor:
Margaret T. Ho, Kotoe Kawai, Dhana Abdo, Lacrimioara Comanita, Arturo Ortin-Martinez, Yui Ueno, Emily Tsao, Azam Rastgar-Moghadam, Chang Xue, Hong Cui, Valerie A. Wallace, Molly S. Shoichet
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as potential vehicles for delivering therapeutic cargo. However, previo
Externí odkaz:
https://doaj.org/article/adf82bd9d98a46a19caf66f82f4d65a4
Autor:
Philip E. B. Nickerson, Akshay Gurdita, Neno T Pokrajac, Parnian Dolati, Nicole Yan, En Leh Samuel Tsai, Joel Pearson, Valerie A. Wallace, Rod Bremner, Lacrimioara Comanita, Danian Chen, Nobuhiko Tachibana, Arturo Ortín-Martínez, Zhongda C. Liu
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102905-(2021)
iScience
iScience
Summary The mouse eye is used to model central nervous system development, pathology, angiogenesis, tumorigenesis, and regenerative therapies. To facilitate the analysis of these processes, we developed an optimized tissue clearing and depigmentation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15322a5b07b9826c1ad72e8ab8244099
http://www.sciencedirect.com/science/article/pii/S2589004221008737
http://www.sciencedirect.com/science/article/pii/S2589004221008737