Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Arturo Orlacchio"'
Autor:
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Laliotis et al. examine the role of the AKT3-phoshorylated RNA processing factor IWS1 and the IWS1 phosphorylation-dependent alternative splicing of U2AF2 in lung adenocarcinoma cells. The alternatively spliced variant of U2AF2 regulates the nuclear
Externí odkaz:
https://doaj.org/article/4976aacb26fc469e84b6096ba7b23887
Autor:
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-25 (2021)
IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK
Externí odkaz:
https://doaj.org/article/d561adaf19ee4c4ab175614033a5dedb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pancreatic ductal adenocarcinoma (PDAC) represents 90% of all pancreatic cancer cases and shows a high mortality rate among all solid tumors. PDAC is often associated with poor prognosis, due to the late diagnosis that leads to metastasis development
Externí odkaz:
https://doaj.org/article/d42238373297446aac98f633a78a0ab0
Autor:
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/5b5c850325bc4e3a8c96cdcd15103370
Autor:
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/859053680f90418f9f1e997cd1ac2603
Autor:
Arturo Orlacchio, Pellegrino Mazzone
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12743 (2021)
Pancreatic cancer (PC) is one of the most lethal forms of cancer, characterized by its aggressiveness and metastatic potential. Despite significant improvements in PC treatment and management, the complexity of the molecular pathways underlying its d
Externí odkaz:
https://doaj.org/article/8b09ca725cab42ebbda9295af414a452
Publikováno v:
Microorganisms, Vol 9, Iss 6, p 1179 (2021)
Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms by which viral infection leads to tumor development is extremely impo
Externí odkaz:
https://doaj.org/article/ddc0e24d0b6a45ffb6002583fa71b712
Publikováno v:
Pharmaceuticals, Vol 13, Iss 11, p 413 (2020)
Non-small cell lung cancer (NSCLC) remains the most prevalent and one of the deadliest cancers worldwide. Despite recent success, there is still an urgent need for new therapeutic strategies. It is also becoming increasingly evident that combinatoria
Externí odkaz:
https://doaj.org/article/44b5b02638f44e55be339e0818f9716c
Autor:
Arturo Orlacchio, Aaron E Stark, Claudia Foray, Foued Amari, Tyler Sheetz, Erika Reese, Anna Tessari, Krista La Perle, Dario Palmieri, Philip N Tsichlis, Vincenzo Coppola
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0201030 (2018)
IWS1 is an RNA-polymerase II (RNAPII)-associated transcription elongation factor whose biological functions are poorly characterized. To shed some light on the function of this protein at the organismal level, we performed a systematic tissue analysi
Externí odkaz:
https://doaj.org/article/bbb0800d30d449239e1b71c4fa1f0e8c
Autor:
Antonio Di Cristofano, Phillip Hawkins, Karen E. Anderson, Daniela De Martino, Toni Forde, Valeria Antico Arciuch, Martina Brave, Michela Ranieri, Arturo Orlacchio
Effect of the Pdk1 L155E allele on the incidence of hyperplasia, solid nodules, and carcinomas in male Ptenthyr-/- mice at 60 weeks of age.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e973bd8eccd589b7766e4d7570ea5e
https://doi.org/10.1158/0008-5472.22414295
https://doi.org/10.1158/0008-5472.22414295