Výsledky vyhledávání - "Arturo Donetti"

Gastroprokinetic properties of the benzimidazolone derivative BIMU 1, an agonist at 5-hydroxytryptamine4 and antagonist at 5-hydroxytryptamine3 receptors

Autor: C.A. Rizzi, Herbert Ladinsky, Schiantarelli Pierino, Arturo Donetti, A Schiavone, Giovanni Battista Schiavi, Angelo Sagrada, Raffaele Cesana

Publikováno v: Naunyn-Schmiedeberg’s Archives of Pharmacology. 349:338-345

We have investigated the in vivo motor stimulating and gastroprokinetic properties of the azabicycloalkyl benzimidazolone derivative BIMU 1 (3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H- benzimidazole-1-carboxamide hydrochlor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85eb0fc5489f54a52d9de8a328e4e8a0
https://doi.org/10.1007/bf00170878

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New pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid esters are preferential M1, M3 muscarinic antagonists. Synthesis and bronchospasmolytic activity

Autor: Ezhaya Antoine, Giovanbattista Schiavi, Angelo Sagrada, E. Bellora, Arturo Donetti, Henri Doods, Enzo Cereda

Publikováno v: European Journal of Medicinal Chemistry. 29:411-421

A series of new 3-tropanol and 3-quinuclidinol esters of phenyl-substituted pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid were synthesized and tested for antimuscarinic activity. The compounds showed a preferential in vitro activity at M1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba8113c1be1f84a9b725dcb07b6815c8
https://doi.org/10.1016/0223-5234(94)90068-x

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ChemInform Abstract: Synthesis of a New Class of 2,3-Dihydro-2-oxo-1H-benzimidazole-1- carboxylic Acid Derivatives as Highly Potent 5-HT3 Receptor Antagonists

Autor: Rosamaria Micheletti, Myrna Gil Quintero, Luciano Maiocchi, Ettore Giraldo, Marco Turconi, Massimo Nicola, Arturo Donetti

Publikováno v: ChemInform. 22

A series of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid esters and amides containing a basic azacyclo- or azabicycloalkyl moiety has been synthesized and evaluated for 5-HT3 antagonistic activity in a radioligand binding assay ([3H]ICS 20593

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15131cae1d7d1dbb7344df4c681a5fd0
https://doi.org/10.1002/chin.199104210

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ChemInform Abstract: New Pyrrolidin-, Piperidin- and Azepin-2-oxocarboxylic Acid Esters are Preferential M1, M3 Muscarinic Antagonists. Synthesis and Bronchospasmolytic Activity

Autor: Giovanbattista Schiavi, Arturo Donetti, Enzo Cereda, Angelo Sagrada, Henri Doods, Ezhaya Antoine, E. Bellora

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a2be8a256c68892b43d695a3c71e8d7
https://doi.org/10.1002/chin.199445228

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Pharmacological properties of a novel class of 5-HT3 receptor antagonists

Autor: Arturo Donetti, Antonio Schiavone, Rosella Micheletti, Marco Turconi, Massimo Nicola, Ernesto Montagna, Raffaele Cesana, Angelo Sagrada, C.A. Rizzi

Publikováno v: European Journal of Pharmacology. 203:203-211

The pharmacological profile of six representative members of a novel class of 5-HT3 receptor antagonists is described. The compounds are esters and amides of benzimidazolone-1-carboxylic acid with a basic azabicycloalkyl moiety (compounds 1-3) and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66de7da46317b8ce854e8e2255d217c
https://doi.org/10.1016/0014-2999(91)90716-4

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Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists

Autor: Rosamaria Micheletti, Massimo Nicola, Marco Turconi, Ettore Giraldo, Myrna Gil Quintero, Arturo Donetti, Luciano Maiocchi

Publikováno v: Journal of Medicinal Chemistry. 33:2101-2108

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ba3e9201f711ee5396c6fed5aeea60
https://doi.org/10.1021/jm00170a009

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Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads

Autor: E. Bellora, Enrica Dubini, Arturo Donetti, Ezhaya Antoine, Giovanni Battista Schiavi, Alessandro Brambilla, Rosella Micheletti, Antonio Schiavone, Enzo Cereda, Myrna Gil Quintero

Publikováno v: Journal of Medicinal Chemistry. 33:2108-2113

Amidines (guanidine, formamidine, and acetamidine) were introduced as substitutes for the cationic heads present in atropine, scopolamine, and corresponding quaternary derivatives. Amidine systems are intermediate in structure between tertiary amines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78599fea63e587980a1f4a446489f6c5
https://doi.org/10.1021/jm00170a010

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Guanylpirenzepine Distinguishes Between Neuronal m1 and m4 Muscarinic Receptor Subtypes

Autor: Herbert Ladinsky, Arturo Donetti, E. Monferini, Ettore Giraldo, Enzo Cereda

Publikováno v: Journal of Receptor Research. 10:81-96

Guanylpirenzepine, a polar, non-quaternary analog of pirenzepine, exhibited a novel binding behavior in rat brain regions: in competition binding experiments against [3H]pirenzepine labeling the M1 receptor in membranes from cerebral cortex, hippocam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfba5f7194871b7bc2932d00b1d15955
https://doi.org/10.3109/10799899009064659

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BIMT 17, a 5-HT1A receptor agonist/5-HT2A receptor antagonist, directly activates postsynaptic 5-HT inhibitory responses in the rat cerebral cortex

Autor: Arturo Donetti, Franco Borsini, Giuseppe Bietti, Angelo Ceci

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 352

BIMT 17 (1-[2-[4-(3-trifluoromethyl phenyl) piperazin-1-yl] ethyl] benzimidazol- [1H]-2-one), a 5-HT1A receptor agonist/5-HT2A receptor antagonist (see Borsini et al., accompanying paper), in a dose range of 1-10 mg/kg i.v., dose-dependently inhibite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235fe0aa0c524b6bddf0a814b6a7e8f9
https://doi.org/10.1007/bf00168558

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BIMT 17, a 5-HT2A receptor antagonist and 5-HT1A receptor full agonist in rat cerebral cortex

Autor: Franco Borsini, Giuseppe Bietti, Arturo Donetti, Ettore Giraldo, Marco Parenti, E. Monferini, G. Antonini

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 352

In the search for antidepressant agents with a rapid onset of action, we have found that compound BIMT 17 (1-[2-[4-(3-trifluoromethylphenyl)piperazin-1- yl]ethyl]benzimidazol-[1H]-2-one) shows a good affinity for cerebral cortical 5-HT1A (pKi = 7.72)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4ae251a32d5afb3bc092c4335ab5e3
https://doi.org/10.1007/bf00168557

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