Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Arturo Carabias"'
Autor:
Antonio Rodríguez-Blázquez, Arturo Carabias, Alba Morán-Vaquero, Sergio de Cima, Juan R. Luque-Ortega, Carlos Alfonso, Peter Schuck, José Antonio Manso, Sandra Macedo-Ribeiro, Carmen Guerrero, José M. de Pereda
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background C3G is a guanine nucleotide exchange factor (GEF) that activates Rap1 to promote cell adhesion. Resting C3G is autoinhibited and the GEF activity is released by stimuli that signal through tyrosine kinases. C3G is activated by tyr
Externí odkaz:
https://doaj.org/article/69835b309c8c4fcc8550fc5ffc4c0d4f
Autor:
José A. Manso, Arturo Carabias, Zsuzsa Sárkány, José M. de Pereda, Pedro José Barbosa Pereira, Sandra Macedo-Ribeiro
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT An important feature associated with Candida albicans pathogenicity is its ability to switch between yeast and hyphal forms, a process in which CaRas1 plays a key role. CaRas1 is activated by the guanine nucleotide exchange factor (GEF) CaCd
Externí odkaz:
https://doaj.org/article/91a4ad11f5194a0d9e9376efb1dace40
Autor:
Arturo Carabias, Anders Fuglsang, Piero Temperini, Tillmann Pape, Nicholas Sofos, Stefano Stella, Simon Erlendsson, Guillermo Montoya
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The Class 2 family of CRISPR nucleases named Cas12j, which shares only low sequence identity with other CRISPR nucleases was recently identified in the biggiephage clade of phages. Here, the authors present the cryo-EM structure of a functional Cas12
Externí odkaz:
https://doaj.org/article/0c04ac7b346d45d1bfa7aa86df769b74
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 1 (2021)
Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas th
Externí odkaz:
https://doaj.org/article/2a1d97d348ea4780a29080c5f459a938
Autor:
Giedrius Sasnauskas, Giedre Tamulaitiene, Gytis Druteika, Arturo Carabias, Arunas Silanskas, Darius Kazlauskas, Česlovas Venclovas, Guillermo Montoya, Tautvydas Karvelis, Virginijus Siksnys
Publikováno v:
Nature. 616:384-389
Autor:
Antonio Rodríguez-Blázquez, Arturo Carabias, Alba Morán-Vaquero, Sergio de Cima, Juan R. Luque-Ortega, Carlos Alfonso, Peter Schuck, José Antonio Manso, Sandra Macedo-Ribeiro, Carmen Guerrero, José M. de Pereda
Publikováno v:
Rodríguez-Blázquez, A, Carabias, A, Morán-Vaquero, A, de Cima, S, Luque-Ortega, J R, Alfonso, C, Schuck, P, Manso, J A, Macedo-Ribeiro, S, Guerrero, C & de Pereda, J M 2023, ' Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and-independent mechanisms ', Cell Communication and Signaling, vol. 21, 30 . https://doi.org/10.1186/s12964-023-01042-2
Background C3G is a guanine nucleotide exchange factor (GEF) that activates Rap1 to promote cell adhesion. Resting C3G is autoinhibited and the GEF activity is released by stimuli that signal through tyrosine kinases. C3G is activated by tyrosine pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd197d03a68cc847d778fd7df149efdc
https://doi.org/10.1101/2022.11.24.515150
https://doi.org/10.1101/2022.11.24.515150
Autor:
José A Manso, Arturo Carabias, Zsuzsa Sárkány, José M de Pereda, Pedro José Barbosa Pereira, Sandra Macedo-Ribeiro
Ras-like protein 1 (CaRas1) is a key regulator of the switch between the yeast and hyphal forms of Candida albicans, a feature associated with pathogenesis. CaRas1 is activated by the guanine nucleotide exchange factor (GEF) CaCdc25, triggering hypha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66bc09a8807f663e34bd72332f6ef4d2
https://doi.org/10.1101/2022.08.23.504951
https://doi.org/10.1101/2022.08.23.504951
Autor:
Guillermo Montoya, Tillmann Pape, Simon Erlendsson, Stefano Stella, Anders Fuglsang, Piero Temperini, Nicholas Sofos, Arturo Carabias
Publikováno v:
Nature Communications
Carabias, A, Fuglsang, A, Temperini, P, Pape, T, Sofos, N, Stella, S, Erlendsson, S & Montoya, G 2021, ' Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3 ', Nature Communications, vol. 12, 4476 . https://doi.org/10.1038/s41467-021-24707-3
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Carabias, A, Fuglsang, A, Temperini, P, Pape, T, Sofos, N, Stella, S, Erlendsson, S & Montoya, G 2021, ' Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3 ', Nature Communications, vol. 12, 4476 . https://doi.org/10.1038/s41467-021-24707-3
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
CRISPR-Cas12j is a recently identified family of miniaturized RNA-guided endonucleases from phages. These ribonucleoproteins provide a compact scaffold gathering all key activities of a genome editing tool. We provide the first structural insight int
Autor:
Patricia González-Sáenz, Carmen Guerrero, Sergio de Cima, Arturo Carabias, Alba Morán-Vaquero, José M. de Pereda, María Teresa Gómez-Hernández, Antonio Rodríguez-Blázquez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
C3G is a guanine nucleotide exchange factor (GEF) that regulates cell adhesion and migration by activating the GTPase Rap1. The GEF activity of C3G is stimulated by the adaptor proteins Crk and CrkL and by tyrosine phosphorylation. Here, we uncovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a54a246e722bf348910088dbd97e64
http://hdl.handle.net/10261/222928
http://hdl.handle.net/10261/222928
Autor:
María Teresa Gómez-Hernández, Inés García-Rubio, Arturo Carabias, Noelia Alonso-García, Maaike Kreft, Arnoud Sonnenberg, José M de Pereda, José A. Manso
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Structure 27(6), 952-964.e6 (2019). doi:10.1016/j.str.2019.03.016
instname
Structure 27(6), 952-964.e6 (2019). doi:10.1016/j.str.2019.03.016
Structure 27(6), 952 - 964.e6 (2019). doi:10.1016/j.str.2019.03.016
Mechanical stability of epithelia requires firm attachment to the basement membrane via hemidesmosomes. Dysfunction of hemidesmosomal proteins causes severe skin-blistering dise
Mechanical stability of epithelia requires firm attachment to the basement membrane via hemidesmosomes. Dysfunction of hemidesmosomal proteins causes severe skin-blistering dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4017e26b76bc121fe6d3725a2874c1