Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Artur Wnorowski"'
Autor:
Katarzyna Smolińska, Jan Sobczyński, Aleksandra Szopa, Artur Wnorowski, Ewa Tomaszewska, Siemowit Muszyński, Anna Winiarska-Mieczan, Tomasz Czernecki, Agata Bielak, Katarzyna Dobrowolska, Kacper Smoliński, Renata Klebaniuk, Piotr Dobrowolski
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Obesity is a complex chronic condition associated with multiple health risks, including visceral obesity, which is particularly detrimental. To gain insight into the mechanisms underlying obesity and its associated pathologies, a novel zebra
Externí odkaz:
https://doaj.org/article/6136ed20f46a4298a90b1b4307d6e169
Autor:
Artur Wnorowski, Danuta Dudzik, Michel Bernier, Jakub Wójcik, Guido Keijzers, Alberto Diaz-Ruiz, Karolina Mazur, Yongqing Zhang, Haiyong Han, Morten Scheibye-Knudsen, Krzysztof Jozwiak, Coral Barbas, Irving W. Wainer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Metabolic reprogramming contributes to oncogenesis, tumor growth, and treatment resistance in pancreatic ductal adenocarcinoma (PDAC). Here we report the effects of (R,S′)-4′-methoxy-1-naphthylfenoterol (MNF), a GPR55 antagonist and bias
Externí odkaz:
https://doaj.org/article/ab585d3344ff410ab9d0f234f371e331
Autor:
Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Edyta Pindelska, Gniewomir Latacz, Jolanta Jaśkowska
Publikováno v:
Ultrasonics Sonochemistry, Vol 90, Iss , Pp 106165- (2022)
The chemotype of arylsulfonamide derivatives of cyclic arylguanidines is a source of molecules with valuable biological activities, including antimicrobial and antitumor properties. The methods of the synthesis presented in the literature are charact
Externí odkaz:
https://doaj.org/article/786644e790e6428fbe68881762e7f2a6
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 148, Iss , Pp 112695- (2022)
Cardiotoxicity remains the most common reason for failure during drug development. Recently, the zebrafish (Danio rerio) model has emerged for the evaluation of drug-dependent cardiotoxicity and for the identification of cardioprotective molecules. H
Externí odkaz:
https://doaj.org/article/bfe1eb69fee74240ac93ce9c91d8125c
Publikováno v:
Cancers, Vol 15, Iss 2, p 451 (2023)
Endometrial cancer is the most common female genital tract malignancy in developed countries that occurs predominantly in postmenopausal women. The primary objective of our research was to investigate whether menopause status together with selected c
Externí odkaz:
https://doaj.org/article/070c64ff5a3a4fbab9b3a3345d036b6f
Autor:
Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J. Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili
Publikováno v:
Molecules, Vol 28, Iss 1, p 71 (2022)
Novel multitarget-directed ligands BIGI 4a-d and BIGI 5a-d were designed and synthesized with a simple and cost-efficient procedure via a one-pot three-component Biginelli reaction targeting acetyl-/butyrylcholinesterases inhibition, calcium channel
Externí odkaz:
https://doaj.org/article/c1008cfa0311472f9605360beca986c5
Autor:
Anna Boguszewska-Czubara, Karolina Kula, Artur Wnorowski, Anna Biernasiuk, Łukasz Popiołek, Dawid Miodowski, Oleg M. Demchuk, Radomir Jasiński
Publikováno v:
Saudi Pharmaceutical Journal, Vol 27, Iss 4, Pp 593-601 (2019)
The process of searching for new antibacterial agents is more and more challenging due to the increasing drug resistance which has become a major concern in the field of infection management. Our study presents a synthesis and characterization by IR,
Externí odkaz:
https://doaj.org/article/01cd36b167194b7b91e2c99250ffcc29
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13328 (2021)
G protein-coupled receptor 55 (GPR55) is a recently deorphanized lipid- and peptide-sensing receptor. Its lipidic endogenous agonists belong to lysoglycerophospholipids, with lysophosphatidylinositol (LPI) being the most studied. Peptide agonists der
Externí odkaz:
https://doaj.org/article/84133b072afb413fb95fc0cfc214417d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13497 (2021)
A meta-analysis of publicly available transcriptomic datasets was performed to identify metabolic pathways profoundly implicated in the progression and treatment of inflammatory bowel disease (IBD). The analysis revealed that genes involved in trypto
Externí odkaz:
https://doaj.org/article/cfd92b90dcca4f6884719b40842e7b22
Acute MDMA and Nicotine Co-administration: Behavioral Effects and Oxidative Stress Processes in Mice
Autor:
Barbara Budzynska, Artur Wnorowski, Katarzyna Kaszubska, Grazyna Biala, Marta Kruk-Słomka, Jacek Kurzepa, Anna Boguszewska-Czubara
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
3,4-Methylenedioxy-methylamphetamine (MDMA), a synthetic substance commonly known as ecstasy, is a worldwide recreational drug of abuse. As MDMA and nicotine activate the same neuronal pathways, we examined the influence of co-administration of nicot
Externí odkaz:
https://doaj.org/article/06c30133b8a24152b00162d3e86ba2bc