Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Artur Laski"'
Autor:
Evangelia Lekka, Aleksandra Kokanovic, Simone Mosole, Gianluca Civenni, Sandro Schmidli, Artur Laski, Alice Ghidini, Pavithra Iyer, Christian Berk, Alok Behera, Carlo V. Catapano, Jonathan Hall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The Lin28/let-7 axis regulates metabolic pathways in normal and pathological contexts. Here the authors show that pharmacological inhibition of Lin28 protects against lipid accumulation in multiple preclinical models of nonalcoholic fatty liver disea
Externí odkaz:
https://doaj.org/article/4eb77299f3fe4991b4cc526dc0ff726c
Autor:
Jonathan Hall, Anastasia Ashkinadze, Jan Philipp Becker, Artur Laski, Eva-Maria Manz, Štefan Moravčík, Sebastian Sjöström, Mathilde Vincent
Publikováno v:
CHIMIA, Vol 76, Iss 5 (2022)
The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years. Much of the progress in this field is due to advances in the medicinal chemistry of oligon
Externí odkaz:
https://doaj.org/article/f9611750084e4810b81bed7391298887
Autor:
Lilian Quero, André N. Tiaden, Edveena Hanser, Julien Roux, Artur Laski, Jonathan Hall, Diego Kyburz
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Objectives: Macrophages are conventionally classified as pro-inflammatory (M1) and anti-inflammatory (M2) functional types. There is evidence for a predominance of macrophages with an inflammatory phenotype (M1) in the rheumatoid arthritis (RA) synov
Externí odkaz:
https://doaj.org/article/69530603d9e34f418f8a3dcf793fcc6a
Autor:
Sandip A. Shelke, Yaming Shao, Artur Laski, Deepak Koirala, Benjamin P. Weissman, James R. Fuller, Xiaohong Tan, Tudor P. Constantin, Alan S. Waggoner, Marcel P. Bruchez, Bruce A. Armitage, Joseph A. Piccirilli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The DIR2s RNA aptamer activates the fluorescence of cyanine dyes allowing detection of two well-resolved emission colors. Here authors solve the crystal structures of the apo and OTB-SO3 fluorophore-bound DIR2s and show how the fluorophore ligand is
Externí odkaz:
https://doaj.org/article/7a5169ba2e1440eb811c773399e43486
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
MicroRNAs constitute a class of endogenous, non‐coding RNAs that influence various processes within the cell. By base‐pairing to partially‐complementary sites located in the 3’ untranslated region of target messenger RNAs, microRNAs participa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10de5f9f9133b86a0d562b36efbb4a6b
https://doi.org/10.1002/chem.202101171
https://doi.org/10.1002/chem.202101171
Autor:
Timo, Hagen, Artur, Laski, Anneke, Brümmer, Adam, Pruška, Verena, Schlösser, Antoine, Cléry, Frédéric H-T, Allain, Renato, Zenobi, Sven, Bergmann, Jonathan, Hall
Publikováno v:
Journal of the American Chemical Society. 143(37)
It is well-accepted that gene expression is heavily influenced by RNA structure. For instance, stem-loops and G-quadruplexes (rG4s) are dynamic motifs in mRNAs that influence gene expression. Adenosine-to-inosine (A-to-I) editing is a common chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6026838f51eec7ea6cc7edd037b9f5a
https://pubmed.ncbi.nlm.nih.gov/34520206
https://pubmed.ncbi.nlm.nih.gov/34520206
Autor:
Jonathan Hall, Luca F R Gebert, Artur Laski, Souvik Ghosh, Anna L. Malinowska, Mark D. Robinson, Yuluan Wang, Charlotte Soneson, Alexander Kanitz
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 49 (1)
Nucleic Acids Research, 49 (1)
Many microRNAs regulate gene expression via atypical mechanisms, which are difficult to discern using native cross-linking methods. To ascertain the scope of non-canonical miRNA targeting, methods are needed that identify all targets of a given miRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a8cc28e69a441baeca93585424bcc3
https://www.zora.uzh.ch/id/eprint/197428/
https://www.zora.uzh.ch/id/eprint/197428/
Publikováno v:
Febs Letters
Identifying the targetome of a microRNA is key for understanding its functions. Cross-linking and immunoprecipitation (CLIP) methods capture native miRNA-mRNA interactions in cells. Some of these methods yield small amounts of chimeric miRNA-mRNA seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f735f91bb8e4c7d73980db3786aa7a
https://pubmed.ncbi.nlm.nih.gov/33113149
https://pubmed.ncbi.nlm.nih.gov/33113149