Výsledky vyhledávání - "Artur Gontarewicz"

Akademický článek

Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP

Publikováno v: Haematologica, Vol 106, Iss 6 (2020)

A subset of patients with advanced-stage classical Hodgkin Lymphoma (cHL) relapse or progress following standard treatment. Given their dismal prognosis, identifying this group of patients upfront represents an important medical need. While prior res

Externí odkaz: https://doaj.org/article/bf2e0be85a7642f9a6ea80dd88841cf7

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Akademický článek

Aurora Kinase Inhibitor PHA-739358 Suppresses Growth of Hepatocellular Carcinoma In Vitro and in a Xenograft Mouse Model

Autor: Daniel Benten, Gunhild Keller, Alexander Quaas, Jorg Schrader, Artur Gontarewicz, Stefan Balabanov, Melanie Braig, Henning Wege, Jurgen Moll, Ansgar W. Lohse, Tim H. Brummendorf

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 9, Pp 934-944 (2009)

Patients with advanced stages of hepatocellular carcinoma (HCC) face a poor prognosis. Although encouraging clinical results have been obtained with multikinase inhibitor sorafenib, the development of improved therapeutic strategies for HCC remains a

Externí odkaz: https://doaj.org/article/f44d5427273e43cfa4258d1f4c805c2b

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Akademický článek

Abcg2 overexpression represents a novel mechanism for acquired resistance to the multi-kinase inhibitor Danusertib in BCR-ABL-positive cells in vitro.

Autor: Stefan Balabanov, Artur Gontarewicz, Gunhild Keller, Laura Raddrizzani, Melanie Braig, Roberta Bosotti, Jürgen Moll, Edgar Jost, Christine Barett, Imke Rohe, Carsten Bokemeyer, Tessa L Holyoake, Tim H Brümmendorf

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e19164 (2011)

The success of Imatinib (IM) therapy in chronic myeloid leukemia (CML) is compromised by the development of IM resistance and by a limited IM effect on hematopoietic stem cells. Danusertib (formerly PHA-739358) is a potent pan-aurora and ABL kinase i

Externí odkaz: https://doaj.org/article/cfe0611edd20497280a5b2f6003a51ea

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Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer

Autor: Stefan Rose-John, Artur Gontarewicz, Reinhild Holmer, Thomas Becker, Jan-Hendrik Egberts, Holger Kalthoff, Christoph Röcken, Charlotte Hauser, Freya A. Goumas, Carola Heneweer, Georg H. Waetzig, Karen Legler, Ulf Geisen, Maria-Margarete Mende

Publikováno v: International Journal of Cancer. 137:1035-1046

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal human tumors, with radical surgical resection as the only curative treatment option. However, resection is only possible in a small fraction of patients, and about 80% of the patients d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4126f9170a5c6bfae351e9c1046abb9
https://doi.org/10.1002/ijc.29445

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11q21 Rearrangement is a Frequent and Highly Specific Genetic Alteration in Mucoepidermoid Carcinoma

Autor: Rainald Knecht, Till S. Clauditz, Simon Laban, Adrian Münscher, Maria Christina Tsourlakis, Artur Gontarewicz, Guido Sauter, Chia-Jung Wang, Waldemar Wilczak

Publikováno v: Diagnostic Molecular Pathology. 21:134-137

Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Translocation t(11;19)(q21;p13) involving the MECT1 and MAML2 genes has been suggested as a diagnostic marker in these tumors. To determine the specificity of 11q21 loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30831d6d075d55cbba9ccd6bda75c206
https://doi.org/10.1097/pdm.0b013e318255552c

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Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck

Autor: Guido Sauter, Kerstin Borgmann, Pierre Tennstedt, Adrian Münscher, Marco Blessmann, Carsten V. Dalchow, C.-J. Wang, Waldemar Wilczak, Silke Tribius, Artur Gontarewicz, Rainald Knecht, Till S. Clauditz

Publikováno v: Journal of Oral Pathology & Medicine. 42:125-132

Department of Radiation-Oncology,University Medical Center Hamburg-Eppendorf, Hamburg, GermanyBACKGROUND: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) was found overexpressed invarious cancer types suggesting its possible role in carci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1c4fbcf2160e1fb37ffb2ef4f69f316
https://doi.org/10.1111/j.1600-0714.2012.01178.x

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Aurora Kinase Inhibitor PHA-739358 Suppresses Growth of Hepatocellular Carcinoma In Vitro and in a Xenograft Mouse Model

Autor: Tim H. Brümmendorf, Jörg Schrader, Ansgar W. Lohse, Melanie Braig, Stefan Balabanov, Artur Gontarewicz, Henning Wege, Alexander Quaas, Daniel Benten, Gunhild Keller, Jürgen Moll

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 9, Pp 934-944 (2009)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e92a7203da9a7b7708a54787066c93f
https://doi.org/10.1593/neo.09664

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Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I

Autor: Jürgen Moll, Riccardo Colombo, Enrico Pesenti, Gunhild Keller, Stefan Balabanov, Daniel Benten, Tim H. Brümmendorf, Alessio Graziano, Artur Gontarewicz, Carsten Bokemeyer, Walter Fiedler

Publikováno v: Blood. 111:4355-4364

The emergence of resistance to imatinib (IM) mediated by mutations in the BCR-ABL domain has become a major challenge in the treatment of chronic myeloid leukemia (CML). Here, we report on studies performed with a novel small molecule inhibitor, PHA-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4886482d5677cc1c733890fa5b52ff9
https://doi.org/10.1182/blood-2007-09-113175

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