Výsledky vyhledávání - "Arttu Junnila"

Akademický článek

High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice

Autor: Riikka Huhtaniemi, Petra Sipilä, Arttu Junnila, Riikka Oksala, Matias Knuuttila, Arfa Mehmood, Eija Aho, Teemu D. Laajala, Tero Aittokallio, Asta Laiho, Laura Elo, Claes Ohlsson, Malin Hagberg Thulin, Pekka Kallio, Sari Mäkelä, Mika V.J. Mustonen, Matti Poutanen

Publikováno v: iScience, Vol 25, Iss 5, Pp 104287- (2022)

Summary: Antiandrogen treatment resistance is a major clinical concern in castration-resistant prostate cancer (CRPC) treatment. Using xenografts of VCaP cells we showed that growth of antiandrogen resistant CRPC tumors were characterized by a higher

Externí odkaz: https://doaj.org/article/125d518783f44b70a3bc79f19094057c

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SUN-213 Hsd17b3 Knockout Mice Serve As A Model To Define Mechanisms Behind The Altered Endocrine Phenotype Of Patients With Hsd17b3 Mutations

Autor: Petra Sipilä, Leena Strauss, Fu-Ping Zhang, Riikka Huhtaniemi, Matti Poutanen, Arttu Junnila, Ilpo Huhtaniemi, Claes Ohlsson, Noora Kotaja

Publikováno v: Journal of the Endocrine Society

Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) is known to be the primary HSD17B enzyme converting androstenedione (A) to testosterone (T) in human testes, and thus, to be important for sexual maturation in boys and for reproductive health late

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1c6d72cdaf6fed3225451912802bc4
http://europepmc.org/articles/PMC6552858

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