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Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2017 May 30; Vol. 103, pp. 1-4. Date of Electronic Publication: 2017 Mar 28.
Autor:
Sanjeev Ranjan, Stef Bosch, Hannamari Lukkari, Johanna Schirmer, Niina Aaltonen, Heikki J. Nieminen, Vesa-Pekka Lehto, Arto Urtti, Tatu Lajunen, Kirsi Rilla
Publikováno v:
Nanomaterials, Vol 14, Iss 13, p 1089 (2024)
RNA-based therapeutics, including siRNA, have obtained recognition in recent years due to their potential to treat various chronic and rare diseases. However, there are still limitations to lipid-based drug delivery systems in the clinical use of RNA
Externí odkaz:
https://doaj.org/article/50ce1e20b7f44f92b42fd60f0f06139a
Autor:
Stanislav Kalinin, Alexander Kovalenko, Annika Valtari, Alessio Nocentini, Maxim Gureev, Arto Urtti, Mikhail Korsakov, Claudiu T. Supuran, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1005-1011 (2022)
Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II. For all hydrophilic derivatives,
Externí odkaz:
https://doaj.org/article/4bd8215628fd4666b45c04fefe090d2d
Autor:
Kiira Kalke, Liisa M Lund, Marie C Nyman, Alesia A Levanova, Arto Urtti, Minna M Poranen, Veijo Hukkanen, Henrik Paavilainen
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010688 (2022)
Herpes simplex virus type 1 (HSV-1) is a common virus of mankind and HSV-1 infections are a significant cause of blindness. The current antiviral treatment of herpes infection relies on acyclovir and related compounds. However, acyclovir resistance e
Externí odkaz:
https://doaj.org/article/02e880cb9ba6495f80428664759abb33
Autor:
Yashavanthi Mysore, Eva M. del Amo, Sirpa Loukovaara, Marja Hagström, Arto Urtti, Anu Kauppinen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Proliferative vitreoretinopathy (PVR) with rhegmatogenous retinal detachment (RRD) is a complex inflammatory ocular disease. Statins are widely used cholesterol-lowering drugs with putative anti-inflammatory properties. In this study, we hav
Externí odkaz:
https://doaj.org/article/95d06a7734c948688d69d89081f608d3
Autor:
Anusha Balla, Bao Tran, Annika Valtari, Philipp Steven, Camilla Scarpellini, Koen Augustyns, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 118 (2022)
Corneal wound, associated with pain, impaired vision, and even blindness, is the most common ocular injury. In this study, we investigated the effect of a novel ferroptosis inhibitor, UAMC-3203 (10 nM–50 µM), in corneal epithelial wound healing in
Externí odkaz:
https://doaj.org/article/d1136f4a281c4e77b6f05239a3ddcb2a
Autor:
Manlio Fusciello, Flavia Fontana, Siri Tähtinen, Cristian Capasso, Sara Feola, Beatriz Martins, Jacopo Chiaro, Karita Peltonen, Leena Ylösmäki, Erkko Ylösmäki, Firas Hamdan, Otto K. Kari, Joseph Ndika, Harri Alenius, Arto Urtti, Jouni T. Hirvonen, Hélder A. Santos, Vincenzo Cerullo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Cancer therapy using oncolytic virus has shown pre-clinical and clinical efficacy. Here, the authors report ExtraCRAd, an oncolytic virus cloaked with tumour cell membrane and report its therapeutic effects in vitro and in vivo in multiple mouse tumo
Externí odkaz:
https://doaj.org/article/2b72055f0b5e4f6496735a1c2b068f78
Autor:
Stine Harloff-Helleberg, Lies A. L. Fliervoet, Mathias Fanø, Mechthild Schmitt, Maxim Antopolski, Arto Urtti, Hanne Mørck Nielsen
Publikováno v:
Drug Delivery, Vol 26, Iss 1, Pp 532-541 (2019)
Oral drug delivery is an attractive noninvasive alternative to injectables. However, oral delivery of biopharmaceuticals is highly challenging due to low stability during transit in the gastrointestinal tract (GIT), resulting in low systemic bioavail
Externí odkaz:
https://doaj.org/article/de17d752cdc448ca8dd3d8f9834ce964
Autor:
Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno, Juha M.T. Hyttinen, Ali Koskela, Mei Chen, Henri Leinonen, Heikki Tanila, Niko Kivinen, Arto Koistinen, Elisa Toropainen, Marialaura Amadio, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Jerzy Mackiewicz, Maija Mutikainen, Anna-Kaisa Ruotsalainen, Mikko Kettunen, Kimmo Jokivarsi, Debasish Sinha, Kati Kinnunen, Goran Petrovski, Janusz Blasiak, Geir Bjørkøy, Ari Koskelainen, Heli Skottman, Arto Urtti, Antero Salminen, Ram Kannan, Deborah A. Ferrington, Heping Xu, Anna-Liisa Levonen, Pasi Tavi, Anu Kauppinen, Kai Kaarniranta
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 1-12 (2019)
Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves impaired protein degradat
Externí odkaz:
https://doaj.org/article/623c13f35ca24a70a5117e36da09403d