Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Artika P Nath"'
Autor:
Artika P Nath, Asolina Braun, Scott C Ritchie, Francis R Carbone, Laura K Mackay, Thomas Gebhardt, Michael Inouye
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0210495 (2019)
Tissue-resident CD8+ memory T (TRM) cells are immune cells that permanently reside at tissue sites where they play an important role in providing rapid protection against reinfection. They are not only phenotypically and functionally distinct from th
Externí odkaz:
https://doaj.org/article/b88e2c52ede64b6b976de9cd55bda933
Autor:
Scott C Ritchie, Johannes Kettunen, Marta Brozynska, Artika P Nath, Aki S Havulinna, Satu Männistö, Markus Perola, Veikko Salomaa, Mika Ala-Korpela, Gad Abraham, Peter Würtz, Michael Inouye
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223692 (2019)
BackgroundGlycA is a nuclear magnetic resonance (NMR) spectroscopy biomarker that predicts risk of disease from myriad causes. It is heterogeneous; arising from five circulating glycoproteins with dynamic concentrations: alpha-1 antitrypsin (AAT), al
Externí odkaz:
https://doaj.org/article/5ceac96a58344eb8880965da4ef607d4
Autor:
Oneil G Bhalala, Artika P Nath, UK Brain Expression Consortium, Michael Inouye, Christopher R Sibley
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007607 (2018)
Schizophrenia and the affective disorders, here comprising bipolar disorder and major depressive disorder, are psychiatric illnesses that lead to significant morbidity and mortality worldwide. Whilst understanding of their pathobiology remains limite
Externí odkaz:
https://doaj.org/article/0ded89d7102b454ea6c23b3326d331ac
Autor:
Marcela Preininger, Dalia Arafat, Jinhee Kim, Artika P Nath, Youssef Idaghdour, Kenneth L Brigham, Greg Gibson
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003362 (2013)
We describe a novel approach to capturing the covariance structure of peripheral blood gene expression that relies on the identification of highly conserved Axes of variation. Starting with a comparison of microarray transcriptome profiles for a new
Externí odkaz:
https://doaj.org/article/714aab40232b4939b97e1d434e2d5c6b
Autor:
Monica Kanki, Artika P. Nath, Ruidong Xiang, Stephanie Yiallourou, Peter J. Fuller, Timothy J. Cole, Rodrigo Cánovas, Morag J. Young
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Disrupted circadian rhythms have been linked to an increased risk of hypertension and cardiovascular disease. However, many studies show inconsistent findings and are not sufficiently powered for targeted subgroup analyses. Using the UK Biob
Externí odkaz:
https://doaj.org/article/e6d31206a7c94d4d87347ab8e8d4bf47
Autor:
Carles Foguet, Yu Xu, Scott C. Ritchie, Samuel A. Lambert, Elodie Persyn, Artika P. Nath, Emma E. Davenport, David J. Roberts, Dirk S. Paul, Emanuele Di Angelantonio, John Danesh, Adam S. Butterworth, Christopher Yau, Michael Inouye
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, the authors present a method to build genetically personalised metabolic models across tissues to estimate individualised reaction fluxes. A fluxome-wide association study in UK Biobank identifies fluxes associated with metabolites and coronary
Externí odkaz:
https://doaj.org/article/23538818abb444f69d502c15c55eb6de
Autor:
Yu Xu, Scott C. Ritchie, Yujian Liang, Paul R. H. J. Timmers, Maik Pietzner, Loïc Lannelongue, Samuel A. Lambert, Usman A. Tahir, Sebastian May-Wilson, Carles Foguet, Åsa Johansson, Praveen Surendran, Artika P. Nath, Elodie Persyn, James E. Peters, Clare Oliver-Williams, Shuliang Deng, Bram Prins, Jian’an Luan, Lorenzo Bomba, Nicole Soranzo, Emanuele Di Angelantonio, Nicola Pirastu, E. Shyong Tai, Rob M. van Dam, Helen Parkinson, Emma E. Davenport, Dirk S. Paul, Christopher Yau, Robert E. Gerszten, Anders Mälarstig, John Danesh, Xueling Sim, Claudia Langenberg, James F. Wilson, Adam S. Butterworth, Michael Inouye
Publikováno v:
Xu, Y, Ritchie, S C, Liang, Y, Timmers, P R H J, Pietzner, M, Lannelongue, L, Lambert, S A, Tahir, U A, May-Wilson, S, Foguet, C, Johansson, Å, Surendran, P, Nath, A P, Persyn, E, Peters, J E, Oliver-Williams, C, Deng, S, Prins, B, Luan, J, Bomba, L, Soranzo, N, Di Angelantonio, E, Pirastu, N, Tai, E S, van Dam, R M, Parkinson, H, Davenport, E E, Paul, D S, Yau, C, Gerszten, R E, Mälarstig, A, Danesh, J, Sim, X, Langenberg, C, Wilson, J F, Butterworth, A S & Inouye, M 2023, ' An atlas of genetic scores to predict multi-omic traits ', Nature, vol. 616, no. 7955, pp. 123-131 . https://doi.org/10.1038/s41586-023-05844-9
The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ad66d3a872bd064ddfd33b2ad4f8b7
https://www.pure.ed.ac.uk/ws/files/337957796/An_atlas_of_genetic_scores_to_predict_multi_omic_traits_s41586_023_05844_9.pdf
https://www.pure.ed.ac.uk/ws/files/337957796/An_atlas_of_genetic_scores_to_predict_multi_omic_traits_s41586_023_05844_9.pdf
Autor:
Yu Xu, Scott C. Ritchie, Yujian Liang, Paul R. H. J. Timmers, Maik Pietzner, Loïc Lannelongue, Samuel A. Lambert, Usman A. Tahir, Sebastian May-Wilson, Åsa Johansson, Praveen Surendran, Artika P Nath, Elodie Persyn, James E. Peters, Clare Oliver-Williams, Shuliang Deng, Bram Prins, Carles Foguet, Jian’an Luan, Lorenzo Bomba, Nicole Soranzo, Emanuele Di Angelantonio, Nicola Pirastu, E Shyong Tai, Rob M van Dam, Emma E Davenport, Dirk S. Paul, Christopher Yau, Robert E. Gerszten, Anders Mälarstig, John Danesh, Xueling Sim, Claudia Langenberg, James F. Wilson, Adam S. Butterworth, Michael Inouye
Genetically predicted levels of multi-omic traits can uncover the molecular underpinnings of common phenotypes in a highly efficient manner. Here, we utilised a large cohort (INTERVAL; N=50,000 participants) with extensive multi-omic data for plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b56e4397af439f00ad888c393f4e3f8d
https://doi.org/10.1101/2022.04.17.488593
https://doi.org/10.1101/2022.04.17.488593
Autor:
Adrian Tran, Artika P. Nath, Sarah C. Moody, Darren C. Henstridge, Christine Yang, Michael Inouye, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling, Brian G. Drew, Simon T. Bond, Yingying Liu, E. King, Natalie A. Mellett, Peter J. Meikle, Anna C. Calkin
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (Trim28), a gene proposed to primarily i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784e2d9bef8833ea989b6eeccecd7963
https://www.repository.cam.ac.uk/handle/1810/315660
https://www.repository.cam.ac.uk/handle/1810/315660
Autor:
Scott C. Ritchie, Shu Mei Teo, Agus Salim, Marta Brozynska, Michael Inouye, Chiea Chuen Khor, Howard H.F. Tang, Patrick G. Holt, Danny Mok, Barbara J. Holt, Andrew Bakshi, Qin Qin Huang, Artika P. Nath, Peter D. Sly, Kathryn E. Holt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting myeloid cells and CD4+ T cells f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fab7478af111684e2e5e475cdba722a
https://www.repository.cam.ac.uk/handle/1810/309611
https://www.repository.cam.ac.uk/handle/1810/309611