Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Artificially Expanded Genetic Information System"'
Autor:
Laos, Roberto
Publikováno v:
Revista de Química; Vol. 22, Núm. 1-2 (2008); 33-46
Evolución dirigida de proteínas: La evolución dirigida es una técnica que nos permite explorar funciones enzimáticas que no son requeridas en el ambiente natural. Esta técnica, simula procesos genéticos naturales y de selección. Esta estrateg
Externí odkaz:
http://revistas.pucp.edu.pe/index.php/quimica/article/view/2592/2540
http://repositorio.pucp.edu.pe/index/handle/123456789/99875
http://repositorio.pucp.edu.pe/index/handle/123456789/99875
Publikováno v:
Accounts of Chemical Research. 50:1375-1382
Although the fundamental properties of DNA as first proposed by Watson and Crick in 1953 provided a basic understanding of how duplex DNA was organized and might be replicated, it was not until the first crystal structures of DNA (Z-DNA in 1979, B-DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ca0dd36031a290073bc8fde9c51424
https://doi.org/10.1021/acs.accounts.6b00655
https://doi.org/10.1021/acs.accounts.6b00655
Autor:
Joekeem Arizala, Nicole Williams, Sana Batool, Prabodhika Mallikaratchy, Hasan E. Zumrut, Zunyi Yang, Steven A. Benner
Publikováno v:
Biochemistry
Here we are reporting, for the first time, a ligand-guided selection (LIGS) experiment using an artificially expanded genetic information system (AEGIS) to successfully identify an AEGIS–DNA aptamer against T cell receptor-CD3ε expressed on Jurkat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be2f8a0210b37ebb3db6884b86fb66a
https://pubmed.ncbi.nlm.nih.gov/31880917
https://pubmed.ncbi.nlm.nih.gov/31880917
Publikováno v:
Acta Crystallographica Section C Structural Chemistry. 72:952-959
Reported here is the crystal structure of a heterocycle that implements a donor–donor–acceptor hydrogen-bonding pattern, as found in theZcomponent [6-amino-5-nitropyridin-2(1H)-one] of an artificially expanded genetic information system (AEGIS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fafaeba76ff0e1ec39c13f885cc239
https://doi.org/10.1107/s2053229616017071
https://doi.org/10.1107/s2053229616017071
Autor:
Christopher McLendon, Kimberly Stewart, Yuan Wu, Thu Le Trinh, Cheng Cui, Sai Wang, Liqin Zhang, Myong-Sang Kim, Sena Cansiz, I-Ting Teng, Shuo Wan, Zunyi Yang, Kevin M. Bradley, Weijia Hou, Yuan Liu, Qunfeng Wu, Steven A. Benner, Shuichi Hoshika, Chen Liu, Diane J. Rowold, Weihong Tan
Publikováno v:
Angewandte Chemie (International ed. in English), vol 55, iss 40
Laboratory in vitro evolution (LIVE) might deliver DNA aptamers that bind proteins expressed on the surface of cells. Here, we use cell engineering to place on the surface of a liver cell line glypican 3 (GPC3), a possible marker for liver cancer dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baef7e75fa5244a860a26cafd34018d1
https://doi.org/10.1002/anie.201605058
https://doi.org/10.1002/anie.201605058
Publikováno v:
Electrochim Acta
Recently we showed the reduction and oxidation of six natural 2'-deoxynucleosides in the presence of the ambient oxygen using the very broad potential window of a pyrolytic graphite electrode (PGE). Using the same procedure, 2'-deoxynucleoside analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafaf2c7ae1725eda5b10298f656a16e
https://doi.org/10.1016/j.electacta.2020.137210
https://doi.org/10.1016/j.electacta.2020.137210
Publikováno v:
The journal of physical chemistry. B. 122(34)
To artificially expand the genetic information system and to realize artificial life, it is necessary to discover new functional DNA bases that can form stable duplex DNA and participate in error-free replication. It is recently proposed that the 2-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e765334d1f4774a598addbefd67a4a
https://pubmed.ncbi.nlm.nih.gov/30063353
https://pubmed.ncbi.nlm.nih.gov/30063353
Autor:
Elisa Biondi, Steven A. Benner
Publikováno v:
Biomedicines, Vol 6, Iss 2, p 53 (2018)
Biomedicines
Biomedicines
Directed evolution was first applied to diverse libraries of DNA and RNA molecules a quarter century ago in the hope of gaining technology that would allow the creation of receptors, ligands, and catalysts on demand. Despite isolated successes, the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1427c372e236827e729ad4e3e4242c2
http://www.mdpi.com/2227-9059/6/2/53
http://www.mdpi.com/2227-9059/6/2/53
Autor:
Shaolong Zhang, Dezhan Chen, Xie-Huang Sheng, Jian-Biao Liu, Wenjuan Wang, Fang Huang, Chuanzhi Sun
Publikováno v:
Physical Chemistry Chemical Physics. 18:28492-28501
The addition of the unnatural P:Z base pair to the four naturally occurring DNA bases expands the genetic alphabet and yields an artificially expanded genetic information system (AEGIS). Herein, the structural feature of oligonucleotides containing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42befab5b50a62c118c286fbe6f15591
https://doi.org/10.1039/c6cp05594j
https://doi.org/10.1039/c6cp05594j
Autor:
Hyo-Joong Kim, Steven A. Benner
Publikováno v:
Astrobiology. 15:301-306
Following the suggestion that nucleoside analogues having their nucleobases joined to ribose via a carbon-carbon bond might easily arise prebiotically, the glycosylation of uracil carrying electron-donating substituents (Me, OH, OCH3, NH2) at its 5 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a514cd03c919281ab6fe768f6efe96c
https://doi.org/10.1089/ast.2014.1264
https://doi.org/10.1089/ast.2014.1264