Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Arti V. Shinde"'
Autor:
Claudio Humeres, Arti V. Shinde, Anis Hanna, Linda Alex, Silvia C. Hernández, Ruoshui Li, Bijun Chen, Simon J. Conway, Nikolaos G. Frangogiannis
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Repair of the infarcted heart requires TGF-β/Smad3 signaling in cardiac myofibroblasts. However, TGF-β–driven myofibroblast activation needs to be tightly regulated in order to prevent excessive fibrosis and adverse remodeling that may precipitat
Externí odkaz:
https://doaj.org/article/cf5b1c6e35dd4f71ae1a816c353b45b6
Autor:
Bijun Chen, Ruoshui Li, Silvia C. Hernandez, Anis Hanna, Kai Su, Arti V. Shinde, Nikolaos G. Frangogiannis
Publikováno v:
Journal of Molecular and Cellular Cardiology. 171:1-15
TGF-βs regulate macrophage responses, by activating Smad2/3. We have previously demonstrated that macrophage-specific Smad3 stimulates phagocytosis and mediates anti-inflammatory macrophage transition in the infarcted heart. However, the role of mac
Autor:
Anis Hanna, Linda Alex, Prasanth Balasubramanian, Arti V. Shinde, Ruoshui Li, Nikolaos G. Frangogiannis, Claudio Humeres
Publikováno v:
Matrix Biol
Tissue injury results in profound alterations in the collagen network, associated with unfolding of the collagen triple helix, proteolytic degradation and generation of fragments. In the infarcted myocardium, changes in the collagen network are criti
Publikováno v:
Am J Physiol Heart Circ Physiol
In patients with myocardial infarction (MI), cardiac rupture is an uncommon but catastrophic complication. In the mouse model of nonreperfused MI, reported rupture rates are highly variable and depend not only on the genetic background and sex of ani
Autor:
Anis Hanna, Claudio Humeres, Simon J. Conway, Arti V. Shinde, Nikolaos G. Frangogiannis, Linda Alex
Publikováno v:
Circulation Research. 129
Repair of the infarcted heart requires TGF-β/Smad3 signaling in cardiac myofibroblasts and formation of an organized myofibroblast-populated scar. However, TGF-β-driven myofibroblast activation needs to be tightly regulated to prevent excessive fib
Autor:
Simon J. Conway, Bijun Chen, Linda Alex, Shuaibo Huang, Ya Su, Arti V. Shinde, Nikolaos G. Frangogiannis, Claudio Humeres
Publikováno v:
J Mol Cell Cardiol
TGF-βs regulate fibroblast responses, by activating Smad2 or Smad3 signaling, or via Smad-independent pathways. We have previously demonstrated that myofibroblast-specific Smad3 is critically implicated in repair of the infarcted heart. However, the
Publikováno v:
Circulation. 142
Cardiac repair is dependent on myofibroblast TGF-b/Smad3 signaling and subsequent formation of an organized scar. However, to prevent prolonged activation and fibrosis, TGFβ effects are tightly regulated through induction of suppressive signals, suc
Publikováno v:
Circulation Research. 127
Transglutaminase 2 (TG2) expression is increased in infarcted and remodeling hearts and modulates cellular responses through enzymatic effects and non-enzymatic actions. In monocytic cells, TG2 is predominantly expressed by M2 macrophages in both mic
Publikováno v:
Current Pathobiology Reports. 5:145-152
Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understan
Tissue transglutaminase induction in the pressure-overloaded myocardium regulates matrix remodelling
Autor:
Wei Chen, Marcin Dobaczewski, Judith J. de Haan, Nikolaos G. Frangogiannis, Ying Xia, Inderpreet Kaur Madahar, Ya Su, Waqas Hanif, Kang Kon Lee, Gerry Melino, Victor Paulino, Arti V. Shinde, Amit Saxena
Publikováno v:
Cardiovascular Research. 113:892-905
Aims Tissue transglutaminase (tTG) is induced in injured and remodelling tissues, and modulates cellular phenotype, while contributing to matrix cross-linking. Our study tested the hypothesis that tTG may be expressed in the pressure-overloaded myoca