Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Arti Tripathi"'
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011059 (2024)
RpoS is an alternative sigma factor needed for the induction of the general stress response in many gammaproteobacteria. Tight regulation of RpoS levels and activity is required for bacterial growth and survival under stress. In Escherichia coli, var
Externí odkaz:
https://doaj.org/article/d8e25e34b3e446fe82863394b8de86fc
Autor:
Roshan D'Souza, Derrick E. Fouts, Sanjay Vashee, Nacyra Assad-Garcia, Lauren M. Oldfield, Rachel Buzzeo, Arti Tripathi
Publikováno v:
Appl Environ Microbiol
Staphylococcus aureus is an opportunistic pathogen that causes a wide range of infections and food poisoning in humans with antibiotic resistance, specifically to methicillin, compounding the problem. Bacteriophages (phages) provide an alternative tr
Autor:
Christiane Brugger, Alexandra M. Deaconescu, Margaret M. Suhanovsky, Arti Tripathi, Song Tong, Amita Sastry, Joel R. Hoskins, Victoria Dorich, Susan Gottesman, Sue Wickner
Publikováno v:
Genes & Development. 33:718-732
The stationary phase promoter specificity subunit σS (RpoS) is delivered to the ClpXP machinery for degradation dependent on the adaptor RssB. This adaptor-specific degradation of σS provides a major point for regulation and transcriptional reprogr
Publikováno v:
Biochemistry. 58(13)
Temperature-sensitive (Ts) mutants are important tools for understanding the role of essential gene(s), but their molecular basis is not well understood. We use CcdB ( Controller of Cell Death protein B) as a model system to explore the effects of Ts
Autor:
Raghavan Varadarajan, Pankaj C. Jain, Siddharth Patel, Prasanth Kumar, Kritika Gupta, Shruti Khare, Ajai J. Pulianmackal, Nilesh Aghera, Arti Tripathi
Publikováno v:
Molecular Biology and Evolution
Understanding how mutations affect protein activity and organismal fitness is a major challenge. We used saturation mutagenesis combined with deep sequencing to determine mutational sensitivity scores for 1,664 single-site mutants of the 101 residue
Publikováno v:
The FASEB Journal. 32
One of the first identified and best-studied toxin-antitoxin (TA) systems in Escherichia coli is the F-plasmid-based CcdAB system. This system is involved in plasmid maintenance through postsegregational killing. More recently, ccdAB homologs have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e3629226280a0c93d4cfe3c1fe397f
https://europepmc.org/articles/PMC5585702/
https://europepmc.org/articles/PMC5585702/
Autor:
Arti Tripathi, Raghavan Varadarajan
Publikováno v:
Current Opinion in Structural Biology. 24:63-71
Multiple methods currently exist for rapid construction and screening of single-site saturation mutagenesis (SSM) libraries in which every codon or nucleotide in a DNA fragment is individually randomized. Nucleotide sequences of each library member b
Autor:
Devrishi Goswami, Mohit K. Swarnkar, Kanika Bajaj, Purbani Chakrabarti, Arti Tripathi, Rajesh S. Gokhale, Raghavan Varadarajan, Anusmita Sahoo, Bharat V. Adkar
Publikováno v:
Structure. 20(2):371-381
A major bottleneck in protein structure prediction is the selection of correct models from a pool of decoys. Relative activities of similar to 1,200 individual single-site mutants in a saturation library of the bacterial toxin CcdB were estimated by
Autor:
Arti Tripathi, Susan Gottesman
Publikováno v:
Nature. 539:38-39
A previously unknown way in which cells mark proteins for destruction has been found in bacteria — phosphorylation of the amino acid arginine targets proteins for degradation by protease enzymes. See Article p.48 Protein ubiquitination can mark pro