Výsledky vyhledávání - "Arti Raghubar"

Akademický článek

Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues

Autor: Duy Pham, Xiao Tan, Brad Balderson, Jun Xu, Laura F. Grice, Sohye Yoon, Emily F. Willis, Minh Tran, Pui Yeng Lam, Arti Raghubar, Priyakshi Kalita-de Croft, Sunil Lakhani, Jana Vukovic, Marc J. Ruitenberg, Quan H. Nguyen

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)

Abstract Spatial transcriptomics (ST) technologies generate multiple data types from biological samples, namely gene expression, physical distance between data points, and/or tissue morphology. Here we developed three computational-statistical algori

Externí odkaz: https://doaj.org/article/90386dc9c14b4450ad2ce44635d342ec

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Multi-phenotype genome-wide association studies of the Norfolk Island isolate implicate pleiotropic loci involved in chronic kidney disease

Autor: Joanne E. Curran, John Blangero, Ngan K. Tran, Quan Nguyen, Heidi G. Sutherland, Lyn R. Griffiths, Arti Raghubar, Andrew Mallett, Rodney A. Lea, Samuel Holland, Nicholas B. Blackburn, Larisa M. Haupt, Miles C. Benton

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Chronic kidney disease (CKD) is a persistent impairment of kidney function. Genome-wide association studies (GWAS) have revealed multiple genetic loci associated with CKD susceptibility but the complete genetic basis is not yet clear. Since CKD share

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d901f9fdab1911325e13132efaff50de
http://europepmc.org/articles/PMC8484585

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Spatially resolved transcriptome profiles of mammalian kidneys illustrate the molecular complexity of functional nephron segments, cell-to-cell interactions and genetic variants

Autor: Duy Pham, Pui Yeng Lam, Siok Min Teoh, Stacey B. Andersen, Alexander N. Combes, Anne Stewart, Helen Healy, Andrew Mallett, Laura F. Grice, Quan Nguyen, Andrew J. Kassianos, L. Francis, Joanna Crawford, Sohye Yoon, Monica S.Y. Ng, Arti Raghubar, Samuel Holland, Xiao Tan

Understanding the molecular mechanisms underlying mammalian kidney function requires transcriptome profiling of the interplay between cells comprising nephron segments. Traditional transcriptomics requires cell dissociation, resulting in loss of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f9a3034f94be4bbc30dd1b5724fe95d
https://doi.org/10.1101/2020.09.29.317917

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stLearn: integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues

Autor: Arti Raghubar, Xiao Tan, Jun Xu, Jana Vukovic, Marc J. Ruitenberg, Quan Nguyen, Laura F. Grice, Duy Pham, Pui Yeng Lam

Spatial Transcriptomics is an emerging technology that adds spatial dimensionality and tissue morphology to the genome-wide transcriptional profile of cells in an undissociated tissue. Integrating these three types of data creates a vast potential fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c908ec3abbe1e3a410e727fd760808d
https://doi.org/10.1101/2020.05.31.125658

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Thrombospondin type-1 domain-containing 7A and membranous nephropathy – The first retrospective analysis of podocyte antigen prevalence and prognosis in an Australian cohort

Autor: K. Hegerty, Arti Raghubar, Andrew J. Kassianos, Dwarakanathan Ranganathan, Leo Francis, Pedro Henrique França Gois

Publikováno v: Pathology. 53:S26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2924f9c677eb0a6c341e1633549d3439
https://doi.org/10.1016/j.pathol.2021.06.028

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