Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Arthur van Aerschot"'
Autor:
Luping Pang, Vladimir Zanki, Sergei V. Strelkov, Arthur Van Aerschot, Ita Gruic-Sovulj, Stephen D. Weeks
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Crystal structures for all enzyme states of leucyl-tRNA synthetase in Neisseria gonorrhoeae reveal multi-domain conformational changes that correlate with a local peptide-plane flip in the active site to compartmentalize catalytic steps.
Externí odkaz:
https://doaj.org/article/281daae9c0c5428fb6d7c6d3b73993ac
Autor:
Baole Zhang, Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Eveline Lescrinier, Jef Rozenski, Sergei V. Strelkov, Stephen D. Weeks, Arthur Van Aerschot
Publikováno v:
Molecules, Vol 25, Iss 20, p 4751 (2020)
Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation. A series of six amino acids were coupled to the purine-like 7-amino-5-hydroxymethylbenzimidazo
Externí odkaz:
https://doaj.org/article/1539736222b44698a5e71c211dda45c2
Autor:
Akkaladevi Venkatesham, Dhuldeo Kachare, Guy Schepers, Jef Rozenski, Mathy Froeyen, Arthur Van Aerschot
Publikováno v:
Molecules, Vol 20, Iss 3, Pp 4020-4041 (2015)
In further study of our series of six-membered ring-containing nucleic acids, different 1',3'-di-O-methyl altropyranoside nucleoside analogs (DMANA) were synthesized comprising all four base moieties, adenine, cytosine, uracil and guanine. Following
Externí odkaz:
https://doaj.org/article/a3fe33227a894b2387addbb981237870
Autor:
Manesh Nautiyal, Bharat Gadakh, Steff De Graef, Luping Pang, Masroor Khan, Yi Xun, Jef Rozenski, Arthur Van Aerschot
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 180 (2019)
Emerging antibiotic resistance in pathogenic bacteria and reduction of compounds in the existing antibiotics discovery pipeline is the most critical concern for healthcare professionals. A potential solution aims to explore new or existing targets/co
Externí odkaz:
https://doaj.org/article/ad75fea30d8442fb823e1cc75a1150a8
Autor:
Akkaladevi Venkatesham, Sambasiva Rao Pillalamarri, Flore De Wit, Eveline Lescrinier, Zeger Debyser, Arthur Van Aerschot
Publikováno v:
Molecules, Vol 24, Iss 3, p 468 (2019)
In vivo imaging of biological processes is an important asset of modern cell biology. Selectively reacting fluorophores herein are an important tool and click chemistry reactions take a large share in these events. 5-Ethynyl-2′-deoxyuridine (EdU) i
Externí odkaz:
https://doaj.org/article/01eaf417dd954d55a654ea4902bf3754
Autor:
Arthur van Aerschot, Milind Saudi
Publikováno v:
Molecules, Vol 18, Iss 7, Pp 8524-8534 (2013)
Benzhydryl protection of primary and secondary alcohols has been reported previously via reaction with metal alcoholates. Our aim was to find generally useful and very mild conditions for the alcoholic protection and deprotection of nucleosides with
Externí odkaz:
https://doaj.org/article/7a3cb855e1964b21a42a8f36483e3b69
Autor:
Gaston H Vondenhoff, Ksenia Pugach, Bharat Gadakh, Laurence Carlier, Jef Rozenski, Mathy Froeyen, Konstantin Severinov, Arthur Van Aerschot
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79234 (2013)
Microcin C analogues were recently envisaged as important compounds for the development of novel antibiotics. Two issues that may pose problems to these potential antibiotics are possible acquisition of resistance through acetylation and in vivo inst
Externí odkaz:
https://doaj.org/article/3f70f20bc3884ecfad66def5a2ab4576
Publikováno v:
Journal of Nucleic Acids, Vol 2012 (2012)
Externí odkaz:
https://doaj.org/article/9e1e46d532f549a19dcf4d7317239406
Autor:
Evgenii M. Osipov, Ali H. Munawar, Steven Beelen, Daren Fearon, Alice Douangamath, Conor Wild, Stephen D. Weeks, Arthur Van Aerschot, Frank von Delft, Sergei V. Strelkov
Publikováno v:
RSC Chemical Biology
Polyomaviruses are a family of ubiquitous double-stranded DNA viruses many of which are human pathogens. These include BK polyomavirus which causes severe urinary tract infection in immunocompromised patients and Merkel cell polyomavirus associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b1fce72e036baea4be23472be6e453
https://lirias.kuleuven.be/handle/20.500.12942/694475
https://lirias.kuleuven.be/handle/20.500.12942/694475
Autor:
Luping Pang, Stijn Lenders, Evgenii M. Osipov, Stephen D. Weeks, Jef Rozenski, Tatiana Piller, Davie Cappoen, Sergei V. Strelkov, Arthur Van Aerschot
Publikováno v:
International journal of molecular sciences
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15095
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15095
Mycothiol (MSH), the major cellular thiol in Mycobacterium tuberculosis (Mtb), plays an essential role in the resistance of Mtb to various antibiotics and oxidative stresses. MshC catalyzes the ATP-dependent ligation of 1-O-(2-amino-2-deoxy-α-d-gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6097915c37fedc4aeb6b30373ccbad
https://repository.uantwerpen.be/docstore/d:irua:15662
https://repository.uantwerpen.be/docstore/d:irua:15662