Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Arthur Yi Loong Sim"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
mTORC1 is a critical kinase that regulates cell growth and proliferation. Here the authors show that glutamine metabolism is sufficient to restore mTORC1 activity during prolonged amino acid starvation in an autophagy-dependent manner.
Externí odkaz:
https://doaj.org/article/baa64e48583c47e993cde6f66f813394
Autor:
Kenon Chua, Arthur Yi Loong Sim, Eric Yew Meng Yeo, Muhammad Sufyan Bin Masroni, Wah Wah Naw, Sai Mun Leong, Kee Wah Lee, Huey Jin Lim, David M. Virshup, Victor Kwan Min Lee
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4759
Volume 24
Issue 5
Pages: 4759
There is an increasing urgency in the search for new drugs to target high-grade cancers such as osteosarcomas (OS), as these have limited therapeutic options and poor prognostic outlook. Even though key molecular events leading to tumorigenesis are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d09785222bde9f3006c85e683c3e7d
https://doi.org/10.3390/ijms24054759
https://doi.org/10.3390/ijms24054759
Autor:
Eugene Guerrero Odoño, Arthur Yi Loong Sim, Kenneth Tou En Chang, Kenon Chua, Susan Swee-Shan Hue, Nicholas Jin Hong Tan, David M. Virshup, Victor Kwan Min Lee
Publikováno v:
Pathology. 53(2)
Overexpression of WLS, an upstream protein in the Wnt pathway, has been implicated in several non-osteogenic tumours. This study represents the first attempt at evaluating WLS expression in various bone and soft tissue tumours using YJ5, a monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46e3f5326009920ee7a8b0c49cd09ce
https://pubmed.ncbi.nlm.nih.gov/33187685
https://pubmed.ncbi.nlm.nih.gov/33187685
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Activation of autophagy and elevation of glutamine synthesis represent key adaptations to maintain amino acid balance during starvation. In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6ad349904468dd27f5135d328cf7d8
http://link.springer.com/article/10.1038/s41467-017-00369-y
http://link.springer.com/article/10.1038/s41467-017-00369-y
Publikováno v:
Journal of Molecular Endocrinology. 55:197-207
Exercise enhances numerous signalling pathways and activates substrate metabolism in skeletal muscle. Small molecule compounds that activate these cellular responses have been shown to recapitulate the metabolic benefits of exercise. In this study, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfab15b6508b10657f5ea274f4777241
https://doi.org/10.1530/jme-15-0140
https://doi.org/10.1530/jme-15-0140
Autor:
Yun Chau Long, Arthur Yi Loong Sim, Ai Lee Chow, Kenneth Hon Kim Ban, Zhi Yi Wan, Johann Shane Tian, Hayden Weng Siong Tan
Publikováno v:
Hepatology (Baltimore, Md.). 64(4)
UNLABELLED Fibroblast growth factor 19 (FGF19) is an important postprandial enterokine which regulates liver metabolism and hepatocyte proliferation. However, the precise mechanism by which FGF19 regulates these cellular effects is poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da584bf878c98bb8f4140143f2e1ddf5
https://pubmed.ncbi.nlm.nih.gov/27328363
https://pubmed.ncbi.nlm.nih.gov/27328363
Autor:
Hayden Weng Siong Tan1, Arthur Yi Loong Sim1, Su Ling Huang1, Ying Leng2, Yun Chau Long2 bchlongy@nus.edu.sg
Publikováno v:
Journal of Molecular Endocrinology. Dec2015, Vol. 55 Issue 3, p197-207. 11p.