Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Arthur R. Salomon"'
CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response
Autor:
Abdul S. Qadir, Paolo Ceppi, Sonia Brockway, Calvin Law, Liang Mu, Nikolai N. Khodarev, Jung Kim, Jonathan C. Zhao, William Putzbach, Andrea E. Murmann, Zhuo Chen, Wenjing Chen, Xia Liu, Arthur R. Salomon, Huiping Liu, Ralph R. Weichselbaum, Jindan Yu, Marcus E. Peter
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2373-2386 (2017)
Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of transcription 1 (STAT1) and induction of STAT1-regulated genes and that this process is inhibited
Externí odkaz:
https://doaj.org/article/d9d2c0eccc6c4397b26f9a483be369d9
Autor:
Xien Yu Chua, Kenneth P. Callahan, Alijah A. Griffith, Tobias Hildebrandt, Guoping Fu, Mengzhou Hu, Renren Wen, Arthur R. Salomon
The Broad Spectrum Optimization of Selective Triggering (BOOST) approach was recently developed to increase the quantitative depth of the tyrosine phosphoproteome by mass spectrometry-based proteomics. While BOOST has been demonstrated in the Jurkat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41775df9631bdf0993465a54ca8bc525
https://doi.org/10.1101/2022.05.13.491817
https://doi.org/10.1101/2022.05.13.491817
Autor:
Timothy Aballo, Theresa Mensah, Samuel G. Mackintosh, Xien Yu Chua, Ricky D. Edmondson, Arthur R. Salomon
Publikováno v:
Mol Cell Proteomics
Dynamic tyrosine phosphorylation is fundamental to a myriad of cellular processes. However, the inherently low abundance of tyrosine phosphorylation in the proteome and the inefficient enrichment of phosphotyrosine(pTyr)-containing peptides has led t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda9128a0247c902a3229fbe2b6c0a58
https://doi.org/10.1074/mcp.tir119.001865
https://doi.org/10.1074/mcp.tir119.001865
Autor:
Alijah A. Griffith, Arthur R. Salomon, Xiaolei Su, Qian Xiao, Nathan Gordo King, Kenneth P. Callahan
Publikováno v:
J Proteome Res
Chimeric antigen receptor (CAR) is a single-pass transmembrane receptor designed to specifically target and eliminate cancers. While CARs prove highly efficacious against B cell malignancies, the intracellular signaling events which promote CAR T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adec4a00db9045327b0083e7db070b9
https://doi.org/10.1101/2021.09.10.459784
https://doi.org/10.1101/2021.09.10.459784
Autor:
Xien Yu Chua, Arthur R. Salomon
Publikováno v:
J Proteome Res
Activation of the T cell receptor (TCR) leads to a network of early signaling predominantly orchestrated by tyrosine phosphorylation in T cells. The TCR is commonly activated using soluble anti-TCR antibodies, but this approach is not antigen-specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb758ce9cff164c2e83b096d99a810d4
https://europepmc.org/articles/PMC8626127/
https://europepmc.org/articles/PMC8626127/
Autor:
Arthur R. Salomon, Xien Yu Chua
Activation of T cell receptors (TCR) leads to a network of early signaling predominantly orchestrated by tyrosine phosphorylation in T cells. TCR are commonly activated using soluble anti-TCR antibodies, but this approach is not antigen-specific. Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f7aae16d7535d1f86d8e8e8a4e8c15
https://doi.org/10.1101/2021.03.25.436968
https://doi.org/10.1101/2021.03.25.436968
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69641 (2013)
Competing positive and negative signaling feedback pathways play a critical role in tuning the sensitivity of T cell receptor activation by creating an ultrasensitive, bistable switch to selectively enhance responses to foreign ligands while suppress
Externí odkaz:
https://doaj.org/article/b52a4666d0c640b38f369d119bd99581
Publikováno v:
J Proteome Res
While Lck has been widely recognized to play a pivotal role in the initiation of the T cell receptor (TCR) signaling pathway, an understanding of the precise regulation of Lck in T cells upon TCR activation remains elusive. Investigation of protein-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf58ef4e790666bba9d5195f2714d43
https://europepmc.org/articles/PMC7962135/
https://europepmc.org/articles/PMC7962135/
Autor:
Lulu Cao, Yiyuan Ding, Norris Hung, Kebing Yu, Anna Ritz, Benjamin J Raphael, Arthur R Salomon
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46725 (2012)
The SH2-domain-containing leukocyte protein of 76 kDa (SLP-76) plays a critical scaffolding role in T cell receptor (TCR) signaling. As an adaptor protein that contains multiple protein-binding domains, SLP-76 interacts with many signaling molecules
Externí odkaz:
https://doaj.org/article/819cafe9b36541a29c5e3274c42fb840
Autor:
Neel H. Shah, Ondrej Stepanek, Arthur R. Salomon, John Kuriyan, Arthur Weiss, Wan-Lin Lo, Veronika Horkova, Nagib Ahsan
Publikováno v:
Nature immunology
T cell-antigen receptor (TCR) signaling requires the sequential activities of the kinases Lck and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, thus leading to the recruitment, phosphorylation, and activation of Zap70. Lck binds and stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0571a8535a7ebc55e7f0b659b8a1cd
https://doi.org/10.1038/s41590-018-0131-1
https://doi.org/10.1038/s41590-018-0131-1