Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Arthur P. Goldberg"'
Publikováno v:
Biophys J
Stochasticity from gene expression in single cells is known to drive metabolic heterogeneity at the level of cellular populations, which is understood to have important consequences for issues such as microbial drug tolerance and treatment of human d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f346c1e67034c3a6626bfef1cf56375b
https://doi.org/10.1016/j.bpj.2021.10.038
https://doi.org/10.1016/j.bpj.2021.10.038
Stochasticity from gene expression in single cells is known to drive metabolic heterogeneity at the level of cellular populations, which is understood to have important consequences for issues such as microbial drug tolerance and treatment of human d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c96b398d720df243cf6da8fea9233b2
https://doi.org/10.1101/2020.05.22.110577
https://doi.org/10.1101/2020.05.22.110577
Autor:
Balázs Szigeti, John Ap Sekar, Yosef D. Roth, Jonathan R. Karr, Yin Hoon Chew, Arthur P. Goldberg
Publikováno v:
Current Opinion in Biotechnology. 51:97-102
Whole-cell computational models aim to predict cellular phenotypes from genotype by representing the entire genome, the structure and concentration of each molecular species, each molecular interaction, and the extracellular environment. Whole-cell m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3620877419e108600b5c452bb729a397
https://doi.org/10.1016/j.copbio.2017.12.013
https://doi.org/10.1016/j.copbio.2017.12.013
Autor:
David P. Nickerson, Anand Rampadarath, Arthur P. Goldberg, Jonathan R. Karr, Veronica L. Porubsky, Herbert M. Sauro
Publikováno v:
Cell Syst
Summary Like many scientific disciplines, dynamical biochemical modeling is hindered by irreproducible results. This limits the utility of biochemical models by making them difficult to understand, trust, or reuse. We comprehensively list the best pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038564417a50eadfa0f1e4d524738b1d
https://pubmed.ncbi.nlm.nih.gov/32853539
https://pubmed.ncbi.nlm.nih.gov/32853539
Autor:
Jonathan R. Karr, Arthur P. Goldberg
Publikováno v:
Journal of Open Source Software. 5:2685
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a8529787413dddaa1304e55f249e24
https://doi.org/10.21105/joss.02685
https://doi.org/10.21105/joss.02685
Autor:
Nancy J. Minshew, Silvia De Rubeis, Christopher A. Walsh, Arthur P. Goldberg, Christine M. Freitag, Angel Carracedo, Robert Sean Hill, Andreas G. Chiocchetti, Yingleong Chan, Alissa M. D'Gama, Mara Parellada, Sonia N. Kim, Itaru Kushima, Mohammed Uddin, Branko Aleksic, Norio Ozaki, Lauren A. Weiss, Xiaochang Zhang, Elaine T. Lim, Christopher S. Poultney, Menachem Fromer, Celso Arango, Maria J Penzol, Christina M. Hultman, Anne S Kamumbu, Joseph D. Buxbaum, Alexander Kolevzon, George M. Church, Stephen W. Scherer
Publikováno v:
Nature Neuroscience. 23:1176-1176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cddf4e20c716849ad9965629f043d25
https://doi.org/10.1038/s41593-020-0681-z
https://doi.org/10.1038/s41593-020-0681-z
Autor:
Eric Fombonne, Stephen Sanders, Rita M. Cantor, Bernie Devlin, Shan Dong, Kathryn Roeder, Catherine Lord, Mack Y. Su, David H. Ledbetter, Arthur P. Goldberg, Vanessa H. Bal, Nicole A. Teran, Eric M. Morrow, Cai Jinlu, James S. Sutcliffe, Michael F. Walker, Jeffrey D. Mandell, Edwin H. Cook, Elise B. Robinson, Mark J. Daly, Kaitlin E. Samocha, Xin He, Christa Lese Martin, Timothy W. Yu, Donna M. Werling, Donna M. Martin, Arthur L. Beaudet, Michael E. Talkowski, Michael T. Murtha, Joseph D. Buxbaum, John F. Keaney, Dorothy E. Grice, A. Ercument Cicek, A. Jeremy Willsey, Somer L. Bishop, Christopher S. Poultney, Lambertus Klei, Matthew W. State, Daniel Moreno-De-Luca, Louw Smith, A. Gulhan Ercan-Sencicek, Shrikant Mane, Tor Solli-Nowlan, Christopher A. Walsh, Daniel H. Geschwind, Jennifer K. Lowe
Publikováno v:
Neuron
Analysis of de novo CNVs (dnCNVs) from the full Simons Simplex Collection (SSC) (N = 2,591 families) replicates prior findings of strong association with autism spectrum disorders (ASDs) and confirms six risk loci (1q21.1, 3q29, 7q11.23, 16p11.2, 15q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a4fa36fcaf7e0b26f6516fec531489
Autor:
John A. P. Sekar, Jonathan R. Karr, Balázs Szigeti, Arthur P. Goldberg, Saahith Pochiraju, Yosef D. Roth
Whole-cell models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deaf4c0ea5263ebc904ac12ececa30bf
https://europepmc.org/articles/PMC5966287/
https://europepmc.org/articles/PMC5966287/
Autor:
Christine Stevens, Michael E. Zwick, Deepthi Rajagopalan, Mara Parellada, David J. Cutler, Li-San Wang, Norio Ozaki, Jinlu Cai, Lauren A. Weiss, Patricia Jiménez González, Jeffrey C. Barrett, Silvia De Rubeis, Helena Kilpinen, Alexander Kolevzon, Timothy W. Yu, Michael John Owen, Geraldine Dawson, Martin Schulte-Rüther, Jeremy R. Parr, Aarno Palotie, Eftichia Duketis, Lambertus Klei, Irene Lee, Bridget A. Fernandez, Aniko Sabo, Matthew W. State, Sarah Curran, Lucy Crooks, Chad M. Schafer, Avi Ma'ayan, Stephen Sanders, Evan T. Geller, Monica Biscaldi, Stephen W. Scherer, Christopher S. Poultney, Mark J. Daly, Patrick Bolton, Kaija Puura, Maria H. Chahrour, Michael Gill, Li Liu, Louise Gallagher, Ryan K. C. Yuen, Jack A. Kosmicki, Abraham Reichenberg, Christine M. Freitag, Shaun Purcell, Andreas G. Chiocchetti, Peter Szatmari, Sabine M. Klauck, Shih-Chen Fu, Christian R. Marshall, Joseph D. Buxbaum, Tarjinder Singh, Bernie Devlin, Chiao-Feng Lin, A. Ercument Cicek, Karola Rehnström, Pamela Sklar, Otto Valladares, Michael Sachse, Terho Lehtimäki, R. Sean Hill, Arthur P. Goldberg, A. Jeremy Willsey, Jing Lei, Branko Aleksic, Menachem Fromer, Yan Kou, Jessica M. Brownfeld, Annette Voran, Kathryn Roeder, Gerard D. Schellenberg, David Skuse, Thomas Lehner, Hilary Coon, Benjamin M. Neale, Iuliana Ionita-Laza, Kristiina Tammimies, Stephen J. Guter, Christopher A. Walsh, James S. Sutcliffe, Xin-Xin He, Alison L. McInnes, Emily L. Crawford, Nicholas G. Campbell, Angel Carracedo, R. Susan Walker, Edwin H. Cook, Kaitlin E. Samocha, Christina M. Hultman
Publikováno v:
Nature
The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af40051d43c8fefc19ce3594f553e4f
http://europepmc.org/articles/PMC4402723
http://europepmc.org/articles/PMC4402723
Autor:
Jennifer Reichert, Dina Manaa, Ann B. Lee, Stephan Ripke, Kathryn Roeder, Stephen Sanders, Pamela Sklar, Yudi Pawitan, Arthur P. Goldberg, Lambertus Klei, Corneliu A. Bodea, Christina M. Hultman, Bernie Devlin, Trent Gaugler, Joseph D. Buxbaum, Abraham Reichenberg, Sven Sandin, Milind Mahajan, Oscar Svantesson
Publikováno v:
Nature genetics
A key component of genetic architecture is the allelic spectrum influencing trait variability. For autism spectrum disorder (henceforth autism) the nature of its allelic spectrum is uncertain. Individual risk genes have been identified from rare vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541574bf444d8ed8ec41ef8ed8755b59
http://europepmc.org/articles/PMC4137411
http://europepmc.org/articles/PMC4137411