Výsledky vyhledávání - "Arthur P. Chou"

Data from Tumor-Suppressive miR148a Is Silenced by CpG Island Hypermethylation in IDH1-Mutant Gliomas

Autor: Albert Lai, Timothy F. Cloughesy, William H. Yong, Phioanh L. Nghiemphu, Paul S. Mischel, Linda M. Liau, Robert Prins, Horacio Soto, Jean Reiss, Weidong Chen, Jerry J. Lou, Reema R. Mody, Tie Li, Arthur P. Chou, Fei Liu, Reshmi Chowdhury, Sichen Li

Purpose:IDH1/2-mutant gliomas harbor a distinct glioma-CpG island methylation phenotype (G-CIMP) that may promote the initiation and progression of secondary pathway gliomas by silencing tumor-suppressive genes. The potential role of tumor-suppressiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cd711dff9b76e81c4c32e5050b7da9
https://doi.org/10.1158/1078-0432.c.6523713

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Supplementary Figures S1-10 from Tumor-Suppressive miR148a Is Silenced by CpG Island Hypermethylation in IDH1-Mutant Gliomas

Supplementary Figures S1-10. Figure S1. RRBS methylation results of full miR-148a-associated CpG island. Figure S2. The methylation status of IDH1 mutation is prognostic in GBM and Anaplastic Astrocytoma (Grade III). Figure S3. miR-148a promotor CpG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a809342c53d329dfd41a7c49f6afa7
https://doi.org/10.1158/1078-0432.22457841

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Supplementary Tables S1-11 from Tumor-Suppressive miR148a Is Silenced by CpG Island Hypermethylation in IDH1-Mutant Gliomas

Supplementary Tables S1-11. Supplementary Table S1. Patient demographics of the RRBS discovery set. Supplementary Table S2. RRBS Mean Coverage per sample. Supplementary Table S3. RRBS coverage of CpG islands associated with miRNAs. Supplementary Tabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8358ca7ce68c59b74b95f302757c9c14
https://doi.org/10.1158/1078-0432.22457838

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Akademický článek

Inhibitory effects of pesticides on proteasome activity: Implication in Parkinson's disease

Autor: Xue-Feng Wang, Sharon Li, Arthur P. Chou, Jeff M. Bronstein

Publikováno v: Neurobiology of Disease, Vol 23, Iss 1, Pp 198-205 (2006)

Epidemiological studies have suggested a correlation of pesticides and Parkinson's disease (PD) while genetic and biochemical studies have implicated the ubiquitin–proteasome system (UPS) in the pathogenesis of PD. In the present studies, we tested

Externí odkaz: https://doaj.org/article/79e3160c954c459daf80dc49456a16c0

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Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation

Autor: Julia Selfridge, Jerry J. Lou, Albert Lai, Sichen Li, Weidong Chen, Arthur P. Chou, Ruihuan Chen, Kuan-Chung Wu, Kym F. Faull, Mira Zurayk, Heidi S. Phillips, Timothy F. Cloughesy, Linda M. Liau, Richard Everson, Yuzhong Deng

Publikováno v: Neuro-Oncology. 15:57-68

Mutations in isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) are found in a subset of gliomas. Among the many phenotypic differences between mutant and wild-type IDH1/2 gliomas, the most salient is that IDH1/2 mutant glioma patients demonstrate markedl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef20975fe6ef3e4876eb0897fd22fbd0
https://doi.org/10.1093/neuonc/nos261

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Identification of Retinol Binding Protein 1 Promoter Hypermethylation in Isocitrate Dehydrogenase 1 and 2 Mutant Gliomas

Publikováno v: JNCI: Journal of the National Cancer Institute. 104:1458-1469

Mutations in isocitrate dehydrogenase 1 (IDH1) and associated CpG island hypermethylation represent early events in the development of low-grade gliomas and secondary glioblastomas. To identify candidate tumor suppressor genes whose promoter methylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395bfad59d96873d1b6fbe286459b4d9
https://doi.org/10.1093/jnci/djs357

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EPIG-11THE IMPLICATION OF CpG island AND SPINT2 HYPERMETHYLATION IN BOTH IDH1 WILD-TYPE AND MUTANT ADULT DIFFUSE GLIOMAS

Autor: Albert Lai, William H. Yong, Reshmi Chowdhury, Jean Reiss, Arthur P. Chou, Sichen Li, Tie Li, Timothy F. Cloughesy, Linda M. Liau, Fei Liu, Reema R. Mody, Bowen Wei, Huytram N. Nguyen, Phioanh L. Nghiemphu

BACKGROUND: IDH1/2 mutation and associated glioma CpG island methylator phenotype (G-CIMP) is associated with glioma prognosis. G-CIMP is defined as CpG islands hypermethylated in IDH1/2 mutant (IDH1/2MUT) gliomas. G-CIMP thus excludes hypermethylate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9a847833c13c15d50fec9f28e04c6e
https://europepmc.org/articles/PMC4638784/

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Inhibitory effects of pesticides on proteasome activity: Implication in Parkinson's disease

Autor: Jeff M. Bronstein, Arthur P. Chou, Xue-Feng Wang, Sharon Li

Publikováno v: Neurobiology of Disease, Vol 23, Iss 1, Pp 198-205 (2006)

Epidemiological studies have suggested a correlation of pesticides and Parkinson's disease (PD) while genetic and biochemical studies have implicated the ubiquitin-proteasome system (UPS) in the pathogenesis of PD. In the present studies, we tested t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a585ed0b5294d0e358201e7ec1df42dc
https://doi.org/10.1016/j.nbd.2006.02.012

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