Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Arthur Messier"'
Publikováno v:
Neurobiology of Aging. 57:178-185
Decreased clearance of potentially toxic metabolites, due to aging changes, likely plays a significant role in the accumulation of amyloid-beta (Aβ) peptides and other macromolecules in the brain of the elderly and in the patients with Alzheimer's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6768f013148f59f48f15ed3dd8bd064
https://doi.org/10.1016/j.neurobiolaging.2017.05.011
https://doi.org/10.1016/j.neurobiolaging.2017.05.011
Autor:
Gerald D. Silverberg, Miles C. Miller, Conrad E. Johanson, Doreen P. Osgood, David Freestone, Russell M. Church, Arthur Messier, Jason T. Machan, Catharine Chiu
Publikováno v:
Behavioral Neuroscience. 128:523-536
The goals of this research were to describe age-related changes in brain biochemistry and behavior, and the relationships between them. The chronological ages of greatest change are particularly important for targeting interventions. In this experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f40bc11ebfd90ade32e07750bb8663
https://doi.org/10.1037/a0036433
https://doi.org/10.1037/a0036433
Autor:
Jason T. Machan, Conrad E. Johanson, Samir Majmudar, Gerald D. Silverberg, Arthur Messier, John E. Donahue, Edward G. Stopa, Miles C. Miller
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 69:1034-1043
Reduced clearance of amyloid β peptides (Aβ) across the blood-brain barrier contributes to amyloid accumulation in Alzheimer disease. Amyloid β efflux transport is via the endothelial low-density lipoprotein receptor-related protein 1 (LRP-1) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bdfd137ba43510eda2b017256bd756
https://doi.org/10.1097/nen.0b013e3181f46e25
https://doi.org/10.1097/nen.0b013e3181f46e25
Autor:
Miles C. Miller, Conrad E. Johanson, Samir Majmudar, Arthur Messier, Edward G. Stopa, Jason T. Machan, Gerald D. Silverberg, John E. Donahue
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 69:98-108
Aging is the most important single risk factor for developing Alzheimer disease. We measured amyloid-beta peptide (Abeta) levels in rat cerebral cortex and hippocampus during normal aging of Brown-Norway/Fischer rats. Amyloid-beta accumulation was as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829378a58dfd6105d2fc59af347d9589
https://doi.org/10.1097/nen.0b013e3181c8ad2f
https://doi.org/10.1097/nen.0b013e3181c8ad2f
Autor:
Thomas Brinker, John E. Donahue, Kumar Vasudevan, Crissey L Pascale, Gerald D. Silverberg, Miles C. Miller, Conrad E. Johanson, Ilias N Caralopoulos, Ed Sabo, Petra M. Klinge, Edward G. Stopa, Arthur Messier
Publikováno v:
Cerebrospinal Fluid Research, Vol 6, Iss Suppl 2, p S16 (2009)
Cerebrospinal Fluid Research
Cerebrospinal Fluid Research
Background Cognitive deficits in aging, NPH and Alzheimer's disease (AD) are exacerbated by compromised neurogenesis in the dentate gyrus (DG) and subventricular zone (SVZ). We previously found beta-amyloid (Aβ) retention in cortex and hippocampus o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc0f1b3df2f6392c86b5955d58fd4d7
https://doi.org/10.1186/1743-8454-6-s2-s16
https://doi.org/10.1186/1743-8454-6-s2-s16
Autor:
Arthur Messier, Miles C. Miller, Gerald D. Silverberg, Tom A. Saul, John A Duncan, Ilias N Caralopoulos, Samir Majmudar, Stephanie Slone, Conrad E. Johanson, Elizabeth Kenney
Publikováno v:
Cerebrospinal Fluid Research. 6
Background It has been shown that there is an age-related decrease in CSF production in the Fischer rat brain, and that this decrease follows the CNS deposition of amyloid rather than preceding it [1]. We have postulated that amyloid and Tau accumula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d6db30752e7482fd501ad1678b19d3
https://doi.org/10.1186/1743-8454-6-s1-s38
https://doi.org/10.1186/1743-8454-6-s1-s38
Autor:
Mohsen Nouri, Gerald D. Silverberg, Petra M. Klinge, Thomas Brinker, John A Duncan, Anna Heile, Conrad E. Johanson, Arthur Messier
Publikováno v:
Cerebrospinal Fluid Research, Vol 4, Iss Suppl 1, p S4 (2007)
Background Little is known about the cerebellum in NPH. Studies show that neurotransmitter changes in the cerebellum are opposite to the cortex [1,2]. In Kaolin-induced hydrocephalus, increases of A-beta peptides at cortical and hippocampal microvess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3f5e3ead6302464a1f7d06291da65c
https://doi.org/10.1186/1743-8454-4-s1-s4
https://doi.org/10.1186/1743-8454-4-s1-s4
Autor:
Sarah Soltman, Arthur Messier, Thomas Brinker, Stephanie Slone, John A Duncan, Conrad E. Johanson, Petra M. Klinge, Gerald D. Silverberg
Publikováno v:
Cerebrospinal Fluid Research, Vol 4, Iss Suppl 1, p S3 (2007)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b17e18d206f7c8fd72bb52654db36f
https://doaj.org/article/8c4e1eb9c0464116b9a550af91fcf046
https://doaj.org/article/8c4e1eb9c0464116b9a550af91fcf046
Autor:
Gerald D. Silverberg, Petra M. Klinge, Sarah Soltman, Arthur Messier, Edward G. Stopa, John A Duncan, Stephanie Flaherty, Conrad E. Johanson
Publikováno v:
Cerebrospinal Fluid Research, Vol 4, Iss Suppl 1, p S45 (2007)
Background Reduced CSF formation in chronic hydrocephalus (NPH) prompts the question of how the expression of choroid epithelial transporters is altered when flow is disrupted. In the Kaolin model of communicating hydrocephalus, we previously demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c4bb236eafa31afdc4e48d22d5a5e4
https://doi.org/10.1186/1743-8454-4-s1-s45
https://doi.org/10.1186/1743-8454-4-s1-s45
Publikováno v:
ASAIO journal (American Society for Artificial Internal Organs : 1992). 41(3)
Activation of the surface of small diameter polyurethane vascular grafts using radiofrequency glow discharge (RFGD) and covalent linkage of cell attachment oligopeptides may improve graft patency. The effects of RFGD treatment were investigated on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e32d28f8ba551cd922ae66ca0343da
https://pubmed.ncbi.nlm.nih.gov/8573880
https://pubmed.ncbi.nlm.nih.gov/8573880