Výsledky vyhledávání - "Arthur Mazzu"

Influence of renal function on the pharmacokinetics of cerivastatin in normocholesterolemic adults

Autor: T.C. Marbury, E. Kelly, M. C. Liu, Arthur Mazzu, R. Vargas, Pavur Sundaresan, John Lettieri

Publikováno v: European Journal of Clinical Pharmacology. 56:69-74

The influence of impaired renal function on the pharmacokinetics of single and multiple doses of cerivastatin was evaluated in this nonrandomized, non-blinded, 7-day, multiple-dose study.Thirty-five adults between the ages of 21 years and 75 years wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e3d59aac9e7ee76e0692a918144791
https://doi.org/10.1007/s002280050723

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Lack of mutual pharmacokinetic interaction between cerivastatin, a new HMG-CoA reductase inhibitor, and digoxin in healthy normocholesterolemic volunteers

Autor: Arthur Mazzu, John Lettieri, Lee Kaiser, Paul Weber

Publikováno v: Clinical Therapeutics. 21:1563-1575

The potential mutual interaction between cerivastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, and digoxin was assessed in this nonmasked, nonrandomized, multiple-dose study. The effect of cerivastatin 0.2 mg on mean plasma digox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6cc92d318c2e455d3d933c4102fd24
https://doi.org/10.1016/s0149-2918(00)80011-9

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The effect of vardenafil, a selective PDE5 inhibitor, on ischemic threshold, exercise tolerance, and circulatory responses during treadmill exercise in men with stable angina pectoris

Autor: Arthur Mazzu, Steven G. Chrysant, Udho Thadani

Publikováno v: Journal of the American College of Cardiology. 41(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a503a55fd5434c820a08b11c7893a623

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The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease

Autor: William M. Smith, Pavur Sundaresan, Neville Bittar, Richard A. Stein, Kenneth Pomerantz, Puneet Narayan, Robert Tota, Arthur Mazzu, Stephen D. Nash, Udho Thadani, Sharon Larkin, Stephen P. Glasser

Publikováno v: Journal of the American College of Cardiology. 40(11)

Objectives The effect of vardenafil, a potent and highly selective phosphodiesterase-5 (PDE5) inhibitor, on symptom-limited exercise time, time to first awareness of angina, and time to ischemic threshold (ST-segment depression ≥1 mm from baseline)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbd76c1de5421619e7d3a85e5a2531f
https://pubmed.ncbi.nlm.nih.gov/12475462

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Effect of vardenafil, a selective phosphodiesterase 5 inhibitor, on the cardiovascular response to exercise in men with coronary artery disease

Autor: Arthur Mazzu, Udho Thadani

Publikováno v: Journal of the American College of Cardiology. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4495c9414301ccf6d3e6c20fb33438

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Influence of gender on the pharmacokinetics, safety, and tolerability of cerivastatin in healthy adults

Autor: John Lettieri, Arthur Mazzu, Allen H. Heller, Miguel A. Zinny, J. Isaacsohn

Publikováno v: European journal of clinical pharmacology. 56(12)

The pharmacokinetics, safety, and tolerability of cerivastatin, a synthetic HMG-CoA reductase inhibitor were studied in 49 healthy volunteers. In this double-blind, parallel group, multiple-dose study, volunteers were randomized as age-matched, male-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c689d3f89ad43fd365f10f6022b2f8d
https://pubmed.ncbi.nlm.nih.gov/11317478

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The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: a double-blind, placebo-controlled trial in patients with esrd

Autor: Barry M. Brenner, Albert Agro, William F. Keane, Arthur Mazzu

Publikováno v: American journal of kidney diseases : the official journal of the National Kidney Foundation. 37(1 Suppl 2)

The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin)-mediated lowering of serum cholesterol has been associated with a significant reduction in cardiovascular morbidity and mortality. Recent studies suggest that additional non-lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cac62d50edc48891f826442a4237301
https://pubmed.ncbi.nlm.nih.gov/11158861

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Itraconazole alters the pharmacokinetics of atorvastatin to a greater extent than either cerivastatin or pravastatin

Autor: John Lettieri, E. Cooper Shamblen, Kenneth C. Lasseter, Pavur Sundaresen, Arthur Mazzu, Vipin Agarwal

Publikováno v: Clinical pharmacology and therapeutics. 68(4)

Background 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are metabolized by distinct pathways that may alter the extent of drug-drug interactions. Cerivastatin is metabolized by cytochrome P450 (CYP)3A4 and CYP2C8. Atorvastatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fa339ef9809565c45c7e0a7e3f876c
https://pubmed.ncbi.nlm.nih.gov/11061579

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