Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Arthur Marivin"'
Autor:
Mikel Garcia-Marcos, Kshitij Parag-Sharma, Arthur Marivin, Marcin Maziarz, Alex Luebbers, Lien T Nguyen
Publikováno v:
eLife, Vol 9 (2020)
Heterotrimeric G-proteins are signal transducers involved in mediating the action of many natural extracellular stimuli and many therapeutic agents. Non-invasive approaches to manipulate the activity of G-proteins with high precision are crucial to u
Externí odkaz:
https://doaj.org/article/e639ceea457e49acbe12c13e627028c9
Autor:
Alain Ibáñez de Opakua, Kshitij Parag-Sharma, Vincent DiGiacomo, Nekane Merino, Anthony Leyme, Arthur Marivin, Maider Villate, Lien T. Nguyen, Miguel Angel de la Cruz-Morcillo, Juan B. Blanco-Canosa, Sekar Ramachandran, George S. Baillie, Richard A. Cerione, Francisco J. Blanco, Mikel Garcia-Marcos
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and
Externí odkaz:
https://doaj.org/article/66ed9d678b9b4909beb7dc11e3606d2b
Publikováno v:
Cells, Vol 1, Iss 4, Pp 711-737 (2012)
Cells are constantly exposed to endogenous and exogenous cellular injuries. They cope with stressful stimuli by adapting their metabolism and activating various “guardian molecules.” These pro-survival factors protect essential cell constituents,
Externí odkaz:
https://doaj.org/article/dce07a4ad3ef4b1e9c8b18a1ad46551b
Autor:
Nicolas Aznar, Krishna K Midde, Ying Dunkel, Inmaculada Lopez-Sanchez, Yelena Pavlova, Arthur Marivin, Jorge Barbazán, Fiona Murray, Ulrich Nitsche, Klaus-Peter Janssen, Karl Willert, Ajay Goel, Miguel Abal, Mikel Garcia-Marcos, Pradipta Ghosh
Publikováno v:
eLife, Vol 4 (2015)
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G pr
Externí odkaz:
https://doaj.org/article/af5395b5b53c4d27b63c1bcee1f12367
Autor:
Elliott M. Ross, Vincent DiGiacomo, Jason Ear, Arthur Marivin, Pradipta Ghosh, Jingyi Zhao, Marcin Maziarz, Juan B. Blanco-Canosa, Emily A. Mann, Mikel Garcia-Marcos, Isabel Olmos Calvo
Publikováno v:
The Journal of biological chemistry, vol 295, iss 8
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
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Besides being regulated by G-protein–coupled receptors, the activity of heterotrimeric G proteins is modulated by many cytoplasmic proteins. GIV/Girdin and DAPLE (Dvl-associating protein with a high frequency of leucine) are the best-characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6595ca7e09967e3dfa3b731de9859d7f
https://doi.org/10.1074/jbc.ra119.011648
https://doi.org/10.1074/jbc.ra119.011648
Publikováno v:
The Journal of cell biology. 221(5)
Establishment of apicobasal polarity and the organization of the cytoskeleton must operate coordinately to ensure proper epithelial cell shape and function. However, the precise molecular mechanisms by which polarity complexes directly instruct the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cce83c0dd08485ee5f2c2cc7420c1d
https://pubmed.ncbi.nlm.nih.gov/35442398
https://pubmed.ncbi.nlm.nih.gov/35442398
Autor:
Mikel Garcia-Marcos, Veronika Morozova, Anthony Leyme, Arthur Marivin, Dmitry A. Kretov, Daniel Cifuentes, Isha A. Walawalkar, Isabel Dominguez
Publikováno v:
The Journal of Cell Biology
This work provides direct evidence that heterotrimeric G proteins can be activated in vivo by a cytoplasmic factor instead of by a GPCR. Specifically, DAPLE, a nonreceptor protein bearing an evolutionarily conserved Gα-binding and -activating (GBA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8645684fd9fb9fdb6b6f34954ec90579
http://europepmc.org/articles/PMC6504902
http://europepmc.org/articles/PMC6504902
Autor:
Stephen R. Sprang, Zhe Chen, Marcin Maziarz, Arthur Marivin, Prachi P. Patel, Mikel Garcia-Marcos, Alex Luebbers, Anthony Leyme
Publikováno v:
Journal of Biological Chemistry. 293:19586-19599
The causative role of G protein–coupled receptor (GPCR) pathway mutations in uveal melanoma (UM) has been well-established. Nearly all UMs bear an activating mutation in a GPCR pathway mediated by G proteins of the G(q/11) family, driving tumor ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9505331259a1926c10004b70370435
https://doi.org/10.1074/jbc.ra118.005291
https://doi.org/10.1074/jbc.ra118.005291
Autor:
Arthur Marivin, Kshitij Parag-Sharma, Lien T. Nguyen, Mikel Garcia-Marcos, Alex Luebbers, Marcin Maziarz
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Heterotrimeric G-proteins are signal transducers that mediate the action of many natural extracellular stimuli as well as of many therapeutic agents. Non-invasive approaches to manipulate the activity of G-proteins with high precision are crucial to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611d9346f5f83b65e797203ce34977b8
https://doi.org/10.7554/elife.60155
https://doi.org/10.7554/elife.60155
