Zobrazeno 1 - 10
of 422
pro vyhledávání: '"Arthur M. Feldman"'
Autor:
Thomas G. Martin, Hana Pak, Glenn S. Gerhard, Salim Merali, Carmen Merali, Bonnie Lemster, Praveen Dubey, Charles F. McTiernan, Michael R. Bristow, Arthur M. Feldman, Jonathan A. Kirk
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 24 (2023)
Background Mutations to the co‐chaperone protein BAG3 (B‐cell lymphoma‐2–associated athanogene‐3) are a leading cause of dilated cardiomyopathy (DCM). These mutations often impact the C‐terminal BAG domain (residues 420–499), which regu
Externí odkaz:
https://doaj.org/article/e00324252d774fae9058422acc540cab
Autor:
Valerie D. Myers, PhD, Gavin P. Landesberg, BS, Marcia L. Bologna, BA, Marc J. Semigran, MD, Arthur M. Feldman, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 7, Iss 9, Pp 951-953 (2022)
Externí odkaz:
https://doaj.org/article/80d35a8dc9f04220a4f6ed022ce9646f
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 23 (2022)
Nonischemic dilated cardiomyopathy is a common form of heart muscle disease in which genetic factors play a critical etiological role. In this regard, both rare disease‐causing mutations and common disease‐susceptible variants, in the Bcl‐2–a
Externí odkaz:
https://doaj.org/article/ce0c10de78394e45b06ecf1f75bed261
Autor:
Thomas G. Martin, Valerie D. Myers, Praveen Dubey, Shubham Dubey, Edith Perez, Christine S. Moravec, Monte S. Willis, Arthur M. Feldman, Jonathan A. Kirk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Decreased expression of BAG3 in the heart is associated with contractile dysfunction and heart failure. Here the authors show that this is due to decreased BAG3-dependent sarcomere protein turnover, which impairs mechanical function, and that sarcome
Externí odkaz:
https://doaj.org/article/e8b11b6fcce64e39a9fa3c8e82869801
BAG3: Nature’s Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue
Autor:
Caitlyn M. Brenner, Muaaz Choudhary, Michael G. McCormick, David Cheung, Gavin P. Landesberg, Ju-Fang Wang, Jianliang Song, Thomas G. Martin, Joseph Y. Cheung, Hui-Qi Qu, Hakon Hakonarson, Arthur M. Feldman
Publikováno v:
Cells, Vol 12, Iss 6, p 937 (2023)
BAG3 is a 575 amino acid protein that is found throughout the animal kingdom and homologs have been identified in plants. The protein is expressed ubiquitously but is most prominent in cardiac muscle, skeletal muscle, the brain and in many cancers. W
Externí odkaz:
https://doaj.org/article/3da901bbcdc74b2c9ceef3cef1832caf
Autor:
Valerie D. Myers, MS, Joseph M. McClung, PhD, JuFang Wang, MD, Farzaneh G. Tahrir, PhD, Manish K. Gupta, PhD, Jennifer Gordon, PhD, Christopher H. Kontos, MD, Kamel Khalili, PhD, Joseph Y. Cheung, MD, PhD, Arthur M. Feldman, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 1, Pp 122-131 (2018)
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins in facilitating autophagy;
Externí odkaz:
https://doaj.org/article/33d9e8f9566344c191444dc53631ac00
Autor:
Manish K. Gupta, Rafal Kaminski, Brian Mullen, Jennifer Gordon, Tricia H. Burdo, Joseph Y. Cheung, Arthur M. Feldman, Muniswamy Madesh, Kamel Khalili
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Cardiovascular disease is a leading cause of co-morbidity in HIV-1 positive patients, even those in whom plasma virus levels are well-controlled. The pathogenic mechanism of HIV-1-associated cardiomyopathy is unknown, but has been presumed t
Externí odkaz:
https://doaj.org/article/9ad17bb03abc452586a3880c4d4e1833
Autor:
Tijana Knezevic, PhD, Valerie D. Myers, MS, Feifei Su, MD, PhD, JuFang Wang, MD, Jianliang Song, MD, PhD, Xue-Qian Zhang, MD, Erhe Gao, MD, PhD, Guofeng Gao, MD, PhD, Muniswamy Madesh, PhD, Manish K. Gupta, PhD, Jennifer Gordon, PhD, Kristen N. Weiner, BS, Joseph Rabinowitz, PhD, Frederick V. Ramsey, PhD, Douglas G. Tilley, PhD, Kamel Khalili, PhD, Joseph Y. Cheung, MD, PhD, Arthur M. Feldman, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 647-656 (2016)
Mutations in Bcl-2–associated athanogene 3 (BAG3) were associated with skeletal muscle dysfunction and dilated cardiomyopathy. Retro-orbital injection of an adeno-associated virus serotype 9 expressing BAG3 (rAAV9-BAG3) significantly (p < 0.0001) i
Externí odkaz:
https://doaj.org/article/70f170720da34f2985f48ff26cb0cbfd
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 10 (2019)
Externí odkaz:
https://doaj.org/article/3b3e0ecbb5a84a4ba520af4c235e7422
Autor:
Xavier Palomer, Eva Capdevila-Busquets, Gaia Botteri, Mercy M. Davidson, Cristina Rodríguez, José Martínez-González, Francisco Vidal, Emma Barroso, Tung O. Chan, Arthur M. Feldman, Manuel Vázquez-Carrera
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 9, Pp 1081-1091 (2015)
miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-κB, a transcription factor induced by pro-inflammatory molecules (such as TNF-α) that is strongly related to the pathogenesis of cardiac disorders. The ma
Externí odkaz:
https://doaj.org/article/8b25dc11b1554cb3896abdbe27fadd61