Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Arthur M, Brown"'
Autor:
Jesaia Benhorin, Arthur J. Moss, Matthew Bak, Wojciech Zareba, Elizabeth S. Kaufman, Batsheva Kerem, Jeffrey A. Towbin, Silvia Priori, Robert S. Kass, Bernard Attali, Arthur M. Brown, Eckhard Ficker
Publikováno v:
Annals of Noninvasive Electrocardiology, Vol 7, Iss 1, Pp 40-46 (2001)
Objectives: This study assessed the phenotypic variability of LQTS in carriers with the same and with different mutations in the LQT2 gene. Background: Mutations of ion‐channel genes are known to cause the long QT syndrome (LQTS), a disorder associ
Externí odkaz:
https://doaj.org/article/48befc71b3f34de49c996b5276d68d7b
Autor:
Sergey Golitsyn, Gregory K. Feld, Arthur M. Brown, Tristram D. Bahnson, A. John Camm, Howard C. Dittrich, Peter R. Kowey, Albert L. Waldo, Amos Katz, Jason I. Koontz
Publikováno v:
Heart Rhythm. 12:1105-1112
Restoration of sinus rhythm (SR) in patients with atrial fibrillation/atrial flutter (AF/AFL) is limited principally to direct current cardioversion. The multi-ion channel blocker vanoxerine may prove an effective alternative.The purpose of this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6850f5a47a98cd64509b3259c948392e
https://doi.org/10.1016/j.hrthm.2015.02.014
https://doi.org/10.1016/j.hrthm.2015.02.014
Publikováno v:
Biophysical Journal. 110(3)
The effect of drugs on the extracellular field potential of stem cell cardiomyocytes is one of the three components of the new Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative promoted by the FDA to assess the proarrhythmic potential of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db7c72af56efa44cf8fb693a8068f0a
Autor:
Arthur M. Brown, James Kramer, Peter Hawryluk, Howard C. Dittrich, Milos Tatalovic, Carlos A. Obejero-Paz, Andrew Bruening-Wright
Publikováno v:
Scientific Reports
Vanoxerine has been in clinical trials for Parkinsonism, depression and cocaine addiction but lacked efficacy. Although a potent blocker of hERG, it produced no serious adverse events. We attributed the unexpected result to offsetting Multiple Ion Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967d1410d7c4a03dc5de2777b638dc06
http://europepmc.org/articles/PMC4663487
http://europepmc.org/articles/PMC4663487
Autor:
Adrienne T. Dennis, Lu Wang, Carlos A. Obejero-Paz, Peter Hawryluk, Eckhard Ficker, Yuri A. Kuryshev, Arthur M. Brown, Barbara A. Wible
Publikováno v:
Molecular Pharmacology. 66:33-44
Arsenic trioxide (As(2)O(3)) produces dramatic remissions in patients with relapsed or refractory acute promyelocytic leukemia. Its clinical use is burdened by QT prolongation, torsade de pointes, and sudden cardiac death. In the present study, we an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4c5f475c743bbc168e0b1b237a0554
https://doi.org/10.1124/mol.66.1.33
https://doi.org/10.1124/mol.66.1.33
Autor:
Arthur M. Brown, Gary M. Brittenham, Tianen Yang, Carlos A. Obejero-Paz, Matthew N. Levy, Wei-Qiang Dong, Yuri A. Kuryshev
Publikováno v:
Journal of Laboratory and Clinical Medicine. 142:332-340
To evaluate the effects of the iron chelator deferoxamine on the functional and structural manifestations of iron-induced cardiac dysfunction, we measured cardiac power, left ventricular systolic, and diastolic function as (dP/dt)max and (dP/dt)min,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f8c222e4201b30911bece2f7691f4b
https://doi.org/10.1016/s0022-2143(03)00135-5
https://doi.org/10.1016/s0022-2143(03)00135-5
Autor:
Kenneth R. Laurita, Tianen Yang, David S. Rosenbaum, Yuri A. Kuryshev, Gary M. Brittenham, Emil Thomas Chuck, Arthur M. Brown, Wei Qiang Dong
Publikováno v:
Journal of Laboratory and Clinical Medicine. 142:83-89
Cardiac disease with arrhythmia or heart failure is the leading cause of death in patients with thalassemia major and a major complication of other forms of iron overload. Current antiarrhythmic treatment does not appear to alter the clinical course.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53dfab2d4d77074e70b2bc0ea436ec56
https://doi.org/10.1016/s0022-2143(03)00060-x
https://doi.org/10.1016/s0022-2143(03)00060-x
Autor:
John R. Sedor, Sujata Lakhe-Reddy, R. Tyler Miller, Liming Wang, Arthur M. Brown, Jeffrey R. Schelling, Shenaz Khan, Martha Konieczkowski, Karen L. Wu, George Jarad
Publikováno v:
American Journal of Physiology-Renal Physiology. 284:F829-F839
Renal tubular epithelial cell (RTC) apoptosis causes tubular atrophy, a hallmark of renal disease progression. Apoptosis is generally characterized by reduced cell volume and cytosolic pH, but epithelial cells are relatively resistant to shrinkage du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b95775b0718afe26153851d58e43918
https://doi.org/10.1152/ajprenal.00314.2002
https://doi.org/10.1152/ajprenal.00314.2002
Autor:
Wei Qiang Dong, Brian D. Hoit, Matthew N. Levy, Darryl L. Kirkpatrick, Arthur M. Brown, Carlos A. Obejero-Paz, Yuri A. Kuryshev, Tianen Yang, Gary M. Brittenham, Songsak Kiatchoosakun
Publikováno v:
Journal of Laboratory and Clinical Medicine. 140:263-271
Iron-overload cardiomyopathy is the most common cause of death in patients with thalassemia major, yet the associated changes in cardiac function have not been quantified. We studied the effects of iron overload on cardiac function in Mongolian gerbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f026623dd9ebb813bf974bff2c99432
https://doi.org/10.1067/mlc.2002.127725
https://doi.org/10.1067/mlc.2002.127725
Publikováno v:
Journal of Biological Chemistry. 277:4989-4998
Mutations in the human ether-a-gogo-related gene (HERG) K(+) channel gene cause chromosome 7-linked long QT syndrome type 2 (LQT2), which is characterized by a prolonged QT interval in the electrocardiogram and an increased susceptibility to life-thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fadbc95c48b8cdc1c0d2bc58add1da
https://doi.org/10.1074/jbc.m107345200
https://doi.org/10.1074/jbc.m107345200