Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Arthur Lo"'
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2556-2565 (2021)
Abstract Nezulcitinib (TD‐0903), a lung‐selective pan–Janus‐associated kinase (JAK) inhibitor designed for inhaled delivery, is under development for treatment of acute lung injury associated with coronavirus disease 2019 (COVID‐19). This t
Externí odkaz:
https://doaj.org/article/15037cc6b9a34adf8465d0c461bdbabf
Autor:
Borje Darpo, Marie Borin, Georg Ferber, Gerald R. Galluppi, Seth C. Hopkins, Ishani Landry, Arthur Lo, Bhaskar Rege, Larisa Reyderman, Lei Sun, Takao Watanabe, Hongqi Xue, Sally Yasuda
Publikováno v:
The Journal of Clinical Pharmacology. 62:1480-1500
The International Conference on Harmonization (ICH) E14 document was revised in 2015 to allow concentration-corrected QT interval (C-QTc) analysis to be applied to data from early clinical pharmacology studies to exclude a small drug-induced effect o
Publikováno v:
Clinical Autonomic Research
Purpose Ampreloxetine is a novel, selective, long-acting norepinephrine reuptake (NET) inhibitor being investigated as a once-daily oral treatment for symptomatic neurogenic orthostatic hypotension (nOH) in patients with autonomic synucleinopathies.
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease. 14:2305-2318
Purpose Revefenacin, a long-acting muscarinic antagonist for nebulization, has been shown to improve lung function in patients with chronic obstructive pulmonary disease. Here we report pharmacokinetic (PK) and safety results from two multicenter, op
Autor:
Amlan Kumar Patra, Luana Paula dos Santos Ribeiro, Hirut Yirga, Adekayode O. Sonibare, Ahmed R. Askar, Ali H. Hussein, Ryszard Puchala, Arthur Louis Goetsch
Publikováno v:
Animal Nutrition, Vol 16, Iss , Pp 84-95 (2024)
Understanding how different livestock species and breeds respond to consumption of brackish water could improve usage of this resource. Therefore, Angora, Boer, and Spanish goat doelings and Dorper, Katahdin, and St. Croix ewe lambs (6 animals per an
Externí odkaz:
https://doaj.org/article/30425623a63f43928895d9e5237684bf
Publikováno v:
Clinical Pharmacokinetics
Background and Objectives Revefenacin is a lung-selective, long-acting muscarinic antagonist indicated for the maintenance treatment of patients with chronic obstructive pulmonary disease. The objectives of this analysis were to evaluate the pharmaco
Autor:
Jonathan M. Maher, Rui Zhang, Gopinath Palanisamy, Kimberly Perkins, Lynda Liu, Patrick Brassil, Alexander McNamara, Arthur Lo, Adam D. Hughes, Jitendra Kanodia, Svitlana Kulyk, Kristen J. Nikula, Hart S. Dengler, Amy Scandurra, Ingrid Lua, Eric Harstad
Publikováno v:
Toxicology and Applied Pharmacology. 438:115905
Systemic therapies targeting transforming growth factor beta (TGFβ) or TGFβR1 kinase (ALK5) have been plagued by toxicities including cardiac valvulopathy and bone physeal dysplasia in animals, posing a significant challenge for clinical developmen
Publikováno v:
Clinical Pharmacokinetics
Background and Objective Ampreloxetine is a novel norepinephrine reuptake inhibitor in development for the treatment of symptomatic neurogenic orthostatic hypotension. The objectives of this analysis were to define the pharmacokinetics of once-daily
Publikováno v:
Clinical and Translational Science
TD-0714 is an orally active, potent, and selective inhibitor of human neprilysin (NEP) in development for the treatment of chronic heart failure. Oral administration of TD-0714 in rats resulted in dose-dependent and sustained increases in plasma cycl
Autor:
PEDRO M. DE SOUZA, ROBERTO JÚNIO P. DIAS, ARTHUR LOURES, MARIANA F. ROSSI, JOSÉ FELIPE R. AMATO, MARTA D’AGOSTO
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 96, Iss 1 (2024)
Abstract High infestations of epibiont ciliates on vertebrates or invertebrates are normally related to aquaculture tanks or similar environments, and the importance of this relationship in natural habitats is often disregarded. Here, we describe the
Externí odkaz:
https://doaj.org/article/d8efe0ada19745349afa51a111fab6e7