Increased Insulin Sensitivity in Gsα Knockout Mice

Autor: Lee S. Weinstein, Randy Lee, Arthur L. Castle, Min Chen, Kyoko Takeda, Shuhua Yu

Publikováno v: Journal of Biological Chemistry. 276:19994-19998

The stimulatory guanine nucleotide-binding protein (G(s)) is required for hormone-stimulated cAMP generation. Gnas, the gene encoding the G(s) alpha-subunit, is imprinted, and targeted disruption of this gene in mice leads to distinct phenotypes in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d163cbc1156fa9b0f40a2cc70d289077
https://doi.org/10.1074/jbc.m010313200

Development of a Standard Reference Material for metabolomics research

Autor: Susan S.-C. Tai, Daniel J. Rabinowitz, Karen W. Phinney, Catherine A. Rimmer, Steven J. Christopher, Karen E. Murphy, Mark S. Lowenthal, Laura J. Wood, Shahzad S. Momin, Zia Fazili, Thomas W. Vetter, William F. Guthrie, Bryant C. Nelson, Mindy Zhang, W. Clay Davis, Carissa D. Powers, Stephen A. Wise, Jessica L. Reiner, Michael E. Rybak, James H. Yen, Gauthier Eppe, Nien-Fan Zhang, Mary Bedner, Brandi Benford, Lane C. Sander, Elizabeth C. Pendergrast, Rosemary L. Schleicher, Guillaume Ballihaut, Jocelyn L. Prendergast, Katherine E. Sharpless, Lorna T. Sniegoski, Michael J. Welch, Charles Hagwood, Brian E. Lang, Huiping Chen, Madhu Chaudhary-Webb, Leslie F. McCoy, Michele M. Schantz, Stephen E. Long, Bridgette M. H. Toombs, Stefan D. Leigh, Donna J LaVoie, Nathan G. Dodder, Johanna E. Camara, Neelima Paladugula, Elizabeth A. McGaw, Arthur L. Castle, Christine M. Pfeiffer, Jeanice M. Brown Thomas, Mary Xu

Publikováno v: Analytical chemistry. 85(24)

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf725c2cc0d0da225f37d6227b6c07a7
https://pubmed.ncbi.nlm.nih.gov/24187941

Metabolomics Standards Workshop and the development of international standards for reporting metabolomics experimental results

Autor: Rima Kaddurah-Daouk, Arthur L. Castle, John C. Lindon, Oliver Fiehn

Publikováno v: Briefings in bioinformatics. 7(2)

Informatics standards and controlled vocabularies are essential for allowing information technology to help exchange, manage, interpret and compare large data collections. In a rapidly evolving field, the challenge is to work out how best to describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8e1e1cf37473b536db7dce74153c2c
https://pubmed.ncbi.nlm.nih.gov/16772263

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

Autor: Arthur L. Castle, Gerald I. Shulman, Joëlle Dupont, Derek Le Roith, Shoshana Yakar, Catalina Hernández-Sánchez, Jonathan Filmore, Ana M. Fernandez, Jason K. Kim

Publikováno v: Genes and Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2001, 15 (15), pp.1926-1934. ⟨10.1101/gad.908001⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Genes and Development 15 (15), 1926-1934. (2001)

9 páginas, 5 figuras, 3 tablas -- PAGS nros. 1926-1934
Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major disorder occurs in muscle, where gluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355a492f5598f81dbcd100ff1cdaec70
https://pubmed.ncbi.nlm.nih.gov/11485987

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

Autor: Mary-Jane Zarnowski, Arthur L. Castle, Yousuke Ebina, Yoshiaki Kido, Hideki Hayashi, Davide Lauro, Domenico Accili

Type 2 diabetes is a complex metabolic disorder characterized by peripheral insulin resistance and impaired beta cell function. Insulin resistance is inherited as a non-mendelian trait. In genetically predisposed individuals, resistance of skeletal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed90d9232e94c6f3ded12fca2088c1a
http://hdl.handle.net/2108/53653