Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Arthur Ko"'
Autor:
Chih-Chiang Chang, Zi-Yu Huang, Shu-Fu Shih, Yuan Luo, Arthur Ko, Qingyu Cui, Jennifer Sumner, Susana Cavallero, Swarna Das, Wei Gao, Janet Sinsheimer, Alex Bui, Jonathan P. Jacobs, Päivi Pajukanta, Holden Wu, Yu-Chong Tai, Zhaoping Li, Tzung K. Hsiai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of cardiometabolic diseases in overweight individuals. While liver biopsy is the current gold standard to diagnose NAFLD and magnetic resonance imaging (MRI) is a non
Externí odkaz:
https://doaj.org/article/0f810a265e014162b2a736b08b17da1c
Autor:
Matthew S. Bramble, Neerja Vashist, Arthur Ko, Sambhawa Priya, Céleste Musasa, Alban Mathieu, D’ Andre Spencer, Michel Lupamba Kasendue, Patrick Mamona Dilufwasayo, Kevin Karume, Joanna Nsibu, Hans Manya, Mary N. A. Uy, Brian Colwell, Michael Boivin, J. P. Banae Mayambu, Daniel Okitundu, Arnaud Droit, Dieudonné Mumba Ngoyi, Ran Blekhman, Desire Tshala-Katumbay, Eric Vilain
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here, using metagenomic profiling in 180 individuals from the Democratic Republic of the Congo, the authors find associations between the gut microbiome and konzo, a neurodegenerative disease that mostly affects children and is caused by the consumpt
Externí odkaz:
https://doaj.org/article/b46fefcdd6e94aef9529183f74cc56a9
Autor:
David Z. Pan, Zong Miao, Caroline Comenho, Sandhya Rajkumar, Amogha Koka, Seung Hyuk T. Lee, Marcus Alvarez, Dorota Kaminska, Arthur Ko, Janet S. Sinsheimer, Karen L. Mohlke, Nicholas Mancuso, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Maria Teresa Tusié-Luna, Carlos Aguilar-Salinas, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Markku Laakso, Kristina M. Garske, Päivi Pajukanta
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-20 (2021)
Abstract Background Obesity predisposes individuals to multiple cardiometabolic disorders, including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat from lean mass, the metabolically detrimental abdominal obesity has
Externí odkaz:
https://doaj.org/article/a78b7b24f81c435489080bb179d2de77
Autor:
Brandon Jew, Marcus Alvarez, Elior Rahmani, Zong Miao, Arthur Ko, Kristina M. Garske, Jae Hoon Sul, Kirsi H. Pietiläinen, Päivi Pajukanta, Eran Halperin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Traditional methods for determining cell type composition lack scalability, while single-cell technologies remain costly and noisy compared to bulk RNA-seq. Here, the authors present a highly efficient tool to measure cellular heterogeneity in bulk e
Externí odkaz:
https://doaj.org/article/07339ac58220420b8ddba6c522aa9592
Autor:
Apolline Gallois, Joel Mefford, Arthur Ko, Amaury Vaysse, Hanna Julienne, Mika Ala-Korpela, Markku Laakso, Noah Zaitlen, Päivi Pajukanta, Hugues Aschard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Genome-wide association studies of metabolites have revealed hundreds of genetic associations using univariate analyses. Here, the authors use a multivariate approach to perform association analyses for 158 serum metabolites, followed by fine mapping
Externí odkaz:
https://doaj.org/article/18f5d61c166a4f04bdb8979fa46f9cb9
Autor:
Jihane N. Benhammou, Arthur Ko, Marcus Alvarez, Minna U. Kaikkonen, Carl Rankin, Kristina M. Garske, David Padua, Yash Bhagat, Dorota Kaminska, Vesa Kärjä, Jussi Pihlajamäki, Joseph R. Pisegna, Päivi Pajukanta
Publikováno v:
Hepatology Communications, Vol 3, Iss 10, Pp 1356-1372 (2019)
The global obesity epidemic is driving the concomitant rise in nonalcoholic fatty liver disease (NAFLD). To identify new genes involved in central liver functions, we examined liver RNA‐sequence data from 259 patients who underwent morbidly obese b
Externí odkaz:
https://doaj.org/article/10c4bc03c6304c95a2394d9a57997ce2
Autor:
Birgitta W. van der Kolk, Sina Saari, Alen Lovric, Muhammad Arif, Marcus Alvarez, Arthur Ko, Zong Miao, Navid Sahebekhtiari, Maheswary Muniandy, Sini Heinonen, Ali Oghabian, Riikka Jokinen, Sakari Jukarainen, Antti Hakkarainen, Jesper Lundbom, Juho Kuula, Per-Henrik Groop, Taru Tukiainen, Nina Lundbom, Aila Rissanen, Jaakko Kaprio, Evan G. Williams, Nicola Zamboni, Adil Mardinoglu, Päivi Pajukanta, Kirsi H. Pietiläinen
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100226- (2021)
Summary: Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-
Externí odkaz:
https://doaj.org/article/4bc712e3168444c09fa1c3ff1ed257df
Autor:
Zong Miao, Marcus Alvarez, Arthur Ko, Yash Bhagat, Elior Rahmani, Brandon Jew, Sini Heinonen, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Carlos Aguilar-Salinas, Teresa Tusie-Luna, Karen L Mohlke, Markku Laakso, Kirsi H Pietiläinen, Eran Halperin, Päivi Pajukanta
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1009018 (2020)
Reverse causality has made it difficult to establish the causal directions between obesity and prediabetes and obesity and insulin resistance. To disentangle whether obesity causally drives prediabetes and insulin resistance already in non-diabetic i
Externí odkaz:
https://doaj.org/article/1b2099002d4a4a2582200aff43ad0675
Autor:
David Z. Pan, Kristina M. Garske, Marcus Alvarez, Yash V. Bhagat, James Boocock, Elina Nikkola, Zong Miao, Chelsea K. Raulerson, Rita M. Cantor, Mete Civelek, Craig A. Glastonbury, Kerrin S. Small, Michael Boehnke, Aldons J. Lusis, Janet S. Sinsheimer, Karen L. Mohlke, Markku Laakso, Päivi Pajukanta, Arthur Ko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
GWAS have identified numerous genetic loci for BMI and related traits. Here, Pan et al. generate Promoter Capture Hi-C data for human white adipocytes and integrate these with data of transcription factor motifs, RNA-seq and GWAS to identify eQTL-eGe
Externí odkaz:
https://doaj.org/article/133629e0a6304f2f8d3499574a04d269
Autor:
David Z. Pan, Zong Miao, Caroline Comenho, Sandhya Rajkumar, Amogha Koka, Seung Hyuk T. Lee, Marcus Alvarez, Dorota Kaminska, Arthur Ko, Janet S. Sinsheimer, Karen L. Mohlke, Nicholas Mancuso, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Maria Teresa Tusié-Luna, Carlos Aguilar-Salinas, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Markku Laakso, Kristina M. Garske, Päivi Pajukanta
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/732d3f0d3a334be5a5f29139e9ab4c14