Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Arthur Kmit"'
Publikováno v:
ERJ Open Research, Vol 7, Iss 4 (2021)
Airway inflammation, mucus hyperproduction and epithelial remodelling are hallmarks of many chronic airway diseases, including asthma, COPD and cystic fibrosis. While several cytokines are dysregulated in these diseases, most studies focus on the res
Externí odkaz:
https://doaj.org/article/7e1dabfd1d9440159ee68b72a41343d1
Autor:
Senne Cuyx, Sofia S. Ramalho, Isabelle Callebaut, Harry Cuppens, Arthur Kmit, Kaline Arnauts, Marc Ferrante, Catherine Verfaillie, Marjolein Ensinck, Marianne S. Carlon, Mieke Boon, Marijke Proesmans, Lieven Dupont, Kris De Boeck, Carlos M. Farinha, François Vermeulen, Anabela S. Ramalho
Publikováno v:
Journal of Cystic Fibrosis. 21:644-651
In cystic fibrosis (CF), genotype-phenotype correlation is complicated by the large number of CFTR variants, the influence of modifier genes, environmental effects, and the existence of complex alleles. We document the importance of complex alleles,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bd19c9d74f42cb6115d132c6f46aca
https://doi.org/10.1016/j.jcf.2022.05.013
https://doi.org/10.1016/j.jcf.2022.05.013
Autor:
Mafalda Bacalhau, Filipa C. Ferreira, Arthur Kmit, Felipe R. Souza, Verônica D. da Silva, André S. Pimentel, Margarida D. Amaral, Camilla D. Buarque, Miquéias Lopes-Pacheco
Publikováno v:
European Journal of Pharmacology. 938:175396
The most prevalent cystic fibrosis (CF)-causing mutation - F508del - impairs the folding of CFTR protein, resulting in its defective trafficking and premature degradation. Small molecules termed correctors may rescue F508del-CFTR and therefore consti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb1e9f811a6a695239b05e398781f8f
https://doi.org/10.1016/j.ejphar.2022.175396
https://doi.org/10.1016/j.ejphar.2022.175396
Publikováno v:
ERJ Open Research, Vol 7, Iss 4 (2021)
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research
article-version (VoR) Version of Record
Airway inflammation, mucus hyperproduction and epithelial remodelling are hallmarks of many chronic airway diseases, including asthma, COPD and cystic fibrosis. While several cytokines are dysregulated in these diseases, most studies focus on the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e1884ba572b064868f19e1775d32a5
http://openres.ersjournals.com/content/7/4/00247-2021.full
http://openres.ersjournals.com/content/7/4/00247-2021.full
Autor:
Marisa Sousa, Maria F Servidoni, Adriana M Vinagre, Anabela S Ramalho, Luciana C Bonadia, Verónica Felício, Maria A Ribeiro, Inna Uliyakina, Fernando A Marson, Arthur Kmit, Silvia R Cardoso, José D Ribeiro, Carmen S Bertuzzo, Lisete Sousa, Karl Kunzelmann, Antônio F Ribeiro, Margarida D Amaral
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47708 (2012)
BackgroundCystic Fibrosis (CF) is caused by ∼1,900 mutations in the CF transmembrane conductance regulator (CFTR) gene encoding for a cAMP-regulated chloride (Cl(-)) channel expressed in several epithelia. Clinical features are dominated by respira
Externí odkaz:
https://doaj.org/article/2860c930e59242669d87fa4093d5ef95
Autor:
Ines Pankonien, Filipa B. Simões, Iris A.L. Silva, Violeta Railean, Margarida C. Quaresma, Luka A. Clarke, Arthur Kmit, Margarida D. Amaral
Publikováno v:
Life Science Alliance
Despite being essential for airway hydration, TMEM16A is not required for mucus (MUC5AC) production. Cell proliferation is the main driver for TMEM16A up-regulation during inflammation.
Airway mucus obstruction is the main cause of morbidity in
Airway mucus obstruction is the main cause of morbidity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3a599cc8a9b9df94097682982a413d
http://europepmc.org/articles/PMC6859295
http://europepmc.org/articles/PMC6859295
Autor:
Arthur Kmit, Margarida D. Amaral, Stéphanie Villa-Nova Pereira, Maria de Fátima Servidoni, Adriana Mendes Vinagre, Gabriela Silva Leite, Fernando Augusto Lima Marson, Carmen Silvia Bertuzzo, Antonio Fernando Ribeiro, José Dirceu Ribeiro
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1865(6)
Background: The variability in response to CFTR modulatory drugs in cystic fibrosis (CF) has recently been associated with modifier genes - namely alternative chloride channels - in individuals with the same CFTR genotype. Objective: To analyze CFTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4618b033f968ddfed78b8ae08c1a062e
https://pubmed.ncbi.nlm.nih.gov/30716472
https://pubmed.ncbi.nlm.nih.gov/30716472
Autor:
Margarida D. Amaral, Arthur Kmit, Udaya Pratap Singh, Hans Raj Bhat, Karina Mendes, Nikhil T. Awatade, Jitendra Kumar Srivastava, Margarida Ramos
Publikováno v:
RSC Advances. 5:88710-88718
Cystic fibrosis (CF) is a monogenetic disease caused mostly by the F508del mutation, a deletion of phenylalanine at position 508 of the CF transmembrane conductance regulator (CFTR) protein, which causes improper localization and functioning of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::462eb7a80b222ccfdba433e0c4eb713c
https://doi.org/10.1039/c5ra09250g
https://doi.org/10.1039/c5ra09250g
Autor:
Arthur Kmit, Antonio de Azevedo Barros-Filho, José Dirceu Ribeiro, Fernando Augusto Lima Marson, Renan Marrichi Mauch, Carlos Emílio Levy
Publikováno v:
Redalyc
ResumoObjetivoRevisar a literatura que aborda a relação entre os parâmetros de crescimento e nutricionais com a função pulmonar em pacientes pediátricos com fibrose cística.Fontes de dadosDados foram coletados de artigos publicados nos último
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5526119e77fd6261802eb501cd75a3
https://doi.org/10.1016/j.rpped.2015.12.002
https://doi.org/10.1016/j.rpped.2015.12.002
Autor:
Yuemin Tian, Rainer Schreiber, Jiraporn Ousingsawat, Arthur Kmit, Patthara Kongsuphol, Karl Kunzelmann, Walailak Jantarajit, Diana Faria, Joana Raquel Martins
Publikováno v:
Experimental Physiology. 97:184-192
Endogenous Ca(2+)-activated Cl(-) currents (CaCCs) are abundant and present in very different cell types. Very good evidence has been provided that endogenous CaCC is produced by anoctamin 1 (Ano1) and Ano2. Insight into the physiological role of ano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4576a6eb05b1a0e86750ea5fc159f0cf
https://doi.org/10.1113/expphysiol.2011.058206
https://doi.org/10.1113/expphysiol.2011.058206