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pro vyhledávání: '"Arthur J.L. Cooper"'
Autor:
Arthur J.L. Cooper
Publikováno v:
EBioMedicine, Vol 2, Iss 9, Pp 1016-1017 (2015)
Externí odkaz:
https://doaj.org/article/4d317bb256224d41ac3cc40a2b97c7af
Autor:
John A. Hanover, Arthur J.L. Cooper
Publikováno v:
Analytical biochemistry. 644
Autor:
Yaroslav Ya Tyno, A. B. Shevelev, Anna A. Lebedeva, Boris F. Krasnikov, Ekaterina Epova, Elena S. Bogdanova, Arthur J.L. Cooper, Yulia K. Biryukova, Yevgeniya I. Shurubor
Publikováno v:
Analytical biochemistry. 632
Nit2/ω-amidase catalyzes the hydrolysis of α-ketoglutaramate (KGM, the α-keto acid analogue of glutamine) to α-ketoglutarate and ammonia. The enzyme also catalyzes the amide hydrolysis of monoamides of 4- and 5-C-dicarboxylates, including α-keto
Publikováno v:
Analytical Biochemistry. 644:114084
The asparaginase II pathway consists of an asparagine transaminase [ l -asparagine + α-keto acid ⇆ α-ketosuccinamate + l -amino acid] coupled to ω-amidase [α-ketosuccinamate + H2O → oxaloacetate + NH4+]. The net reaction is: l -asparagine +
Publikováno v:
Analytical Biochemistry. 644:114083
In rapidly dividing cells, including many cancer cells, l -glutamine is a major energy source. Utilization of glutamine is usually depicted as: l -glutamine → l -glutamate (catalyzed by glutaminase isozymes; GLS1 and GLS2), followed by l -glutamate
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80b47d1e0785d438e75e236fc7a8f9d1
https://doi.org/10.1016/b978-0-12-819460-7.00279-6
https://doi.org/10.1016/b978-0-12-819460-7.00279-6
Publikováno v:
Biomolecules
Volume 10
Issue 1
Volume 10
Issue 1
Many tumors readily convert l-glutamine to &alpha
ketoglutarate. This conversion is almost invariably described as involving deamidation of l-glutamine to l-glutamate followed by a transaminase (or dehydrogenase) reaction. However, mammalian tis
ketoglutarate. This conversion is almost invariably described as involving deamidation of l-glutamine to l-glutamate followed by a transaminase (or dehydrogenase) reaction. However, mammalian tis
Autor:
David Moraga Amador, Arthur J.L. Cooper, Donald R. McCarty, Andrew D. Hanson, Jacob Folz, Oliver Fiehn, Thomas D. Niehaus
Publikováno v:
The Journal of biological chemistry, vol 293, iss 21
Cellular thiols such as cysteine spontaneously and readily react with the respiratory intermediate fumarate, resulting in the formation of stable S-(2-succino)-adducts. Fumarate-mediated succination of thiols increases in certain tumors and in respon
Publikováno v:
Analytical Biochemistry. 632:114206
The use of metabolomics technologies and stable isotope labeling recently enabled us to discover an unexpected role of N-acetyl-aspartyl-glutamate (NAAG): NAAG is a glutamate reservoir for cancer cells. In the current study, we first found that gluco
Publikováno v:
Neurochemical Research. 42:1683-1696
Ammonia is neurotoxic, and chronic hyperammonemia is thought to be a major contributing factor to hepatic encephalopathy in patients with liver disease. Portacaval shunting of rats is used as an animal model to study the detrimental metabolic effects