Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Arthur J. Lustig"'
Autor:
Arthur J. Lustig
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
An in silico study of Aspergillus flavus genome stability uncovered significant variations in both coding and non-coding regions. The non-coding insertions uniformly consisted of AT-rich sequences that are evolutionarily maintained, albeit distribute
Externí odkaz:
https://doaj.org/article/cbe6d7be5db942d6b25926cddcec3247
Autor:
William A. Barr, Ruchi B. Sheth, Jack Kwon, Jungwoo Cho, Jacob W. Glickman, Felix Hart, Om K. Chatterji, Kristen Scopino, Karen Voelkel-Meiman, Daniel Krizanc, Kelly M. Thayer, Michael P. Weir, Arthur J. Lustig
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
Levels of protein translation by ribosomes are governed both by features of the translation machinery as well as sequence properties of the mRNAs themselves. We focus here on a striking three-nucleotide periodicity, characterized by overrepresentatio
Externí odkaz:
https://doaj.org/article/264865e4af8a43b3b3e60eb1402dd83b
Publikováno v:
PLoS ONE, Vol 15, Iss 10 (2020)
Modulation of gene activity by creating mutations has contributed significantly to the understanding of protein functions. Oftentimes, however, mutational analyses use overexpression studies, in which proteins are taken out of their normal contexts a
Externí odkaz:
https://doaj.org/article/4befa093fb9347aea037a9456d72312b
Autor:
Yan Dong, Haitao Zhang, Qun Yu, Arthur J. Lustig, Izumi Horikawa, Paul S. Rennie, Helen Cheng, Clement Ip, Brian G. Rowan, Tamika Duplessis, Yubin Ge, Yanfeng Qi, Shuang Liu
Supplementary Figure 1 from Telomerase as an Important Target of Androgen Signaling Blockade for Prostate Cancer Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05345eeeeeadf09fe58244fa1aa0a9bf
https://doi.org/10.1158/1535-7163.22484670
https://doi.org/10.1158/1535-7163.22484670
Autor:
Yan Dong, Haitao Zhang, Qun Yu, Arthur J. Lustig, Izumi Horikawa, Paul S. Rennie, Helen Cheng, Clement Ip, Brian G. Rowan, Tamika Duplessis, Yubin Ge, Yanfeng Qi, Shuang Liu
As the mainstay treatment for advanced prostate cancer, androgen deprivation therapy (ADT) targets the action of androgen receptor (AR) by reducing androgen level and/or by using anti-androgen to compete with androgens for binding to AR. Albeit effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2189ac6f1fe43970f42a243d34f53da
https://doi.org/10.1158/1535-7163.c.6531522
https://doi.org/10.1158/1535-7163.c.6531522
Autor:
Arthur J. Lustig
Publikováno v:
Trends Cell Biol
A mechanistic understanding of the yeast telomere requires an integrated understanding of telomere chromatin structure (telosomes), telomeric origins of replications, telomere length homeostasis, and telosome epigenetics. Recent molecular and genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f0c889064d9de054661d0071945fac
https://europepmc.org/articles/PMC6465155/
https://europepmc.org/articles/PMC6465155/
In the absence of the RNA-templated reverse transcriptase, telomerase, the predominant means of terminal addition, arises from break-induced replication (BIR) at multiple homologous subtelomeric Y′ loci and among internal homeologous (imperfect) (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5dd530b8970e83801a73acd2ad91ff
https://europepmc.org/articles/PMC5984183/
https://europepmc.org/articles/PMC5984183/
Autor:
Arthur J. Lustig
Publikováno v:
Journal of cancer epidemiology & treatment
Real time qPCR has become the method of choice for rapid large-scale telomere length measurements. Large samples sizes are critical for clinical trials, and epidemiological studies. QPCR has become such routine procedure that it is often used with li
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183549 (2017)
PLoS ONE
PLoS ONE
Telomeres, the nucleoprotein complexes at the termini of linear chromosomes, are essential for the processes of end replication, end-protection, and chromatin segregation. The Mre11 complex is involved in multiple cellular roles in DNA repair and str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f2ae4731b5029eeb49c9d7832c69f8
Autor:
Kurt W. Runge, Arthur J. Lustig
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
Frontiers in Genetics
Frontiers in Genetics
The study of the evolution of the end of chromosomes, or telomeres, has moved from the abstract to molecular observations and mechanistic possibilities. Although successful end-replication and end-protection are the primary driving forces acting at a