Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice

Autor: Kansai Fukumitsu, Misato Kaneko, Teppo Maruyama, Chihiro Yoshihara, Arthur J. Huang, Thomas J. McHugh, Shigeyoshi Itohara, Minoru Tanaka, Kumi O. Kuroda

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

The mechanisms coordinating the sensing and seeking of social contacts are unclear. Here, the authors show that amylin-calcitonin receptor signalling in the media preoptic area mediates affiliative social behaviors in female mice.

Externí odkaz: https://doaj.org/article/24a1ac903d5148b493993a55cbb30e82

Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care

Autor: Arthur J Huang, Eri Miyazawa, Kazushige Touhara, Yousuke Tsuneoka, Kazutaka Shinozuka, Kenichi Tokita, Thomas J. McHugh, Kazunari Miyamichi, Kumi O. Kuroda, Shigeyoshi Itohara, Teppo Maruyama, Katsuhiko Nishimori, Chihiro Yoshihara, Misato Kaneko, Minoru Tanaka, Kansai Fukumitsu

Publikováno v: Cell reports. 35(9)

Maternal mammals exhibit heightened motivation to care for offspring, but the underlying neuromolecular mechanisms have yet to be clarified. Here, we report that the calcitonin receptor (Calcr) and its ligand amylin are expressed in distinct neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267edb8343c4726c626dd80903e618fe
https://pubmed.ncbi.nlm.nih.gov/34077719

Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted L-Pipecolic Acids

Autor: Arthur J Huang, Yi Tang, Mengbin Chen, Yang Hai

Publikováno v: J Am Chem Soc

Fusaric acid (FA) is a well-known mycotoxin that plays an important role in plant pathology. The biosynthetic gene cluster for FA has been identified but the biosynthetic pathway remains unclarified. Here, we elucidated the biosynthesis of FA, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bd3dc3dac456128ef7678afc9feb2b
https://doi.org/10.26434/chemrxiv.12897095

A hypothalamic novelty signal modulates hippocampal memory

Autor: Kana Namiki, Marie E. Wintzer, Arthur J Huang, Steven J. Middleton, Hiroshi Hama, Roman Boehringer, Mingxiao Gu, Hiroyuki Hioki, Shuo Chen, Ludivine Therreau, Denis Polygalov, Linmeng He, Vincent Robert, Thomas J. McHugh, Adam Z. Weitemier, Vivien Chevaleyre, Yanqiu Tao, Atsushi Miyawaki, Rebecca A. Piskorowski

Publikováno v: Nature
Nature, 2020, 586 (7828), pp.270-274. ⟨10.1038/s41586-020-2771-1⟩
Nature, Nature Publishing Group, 2020, 586 (7828), pp.270-274. ⟨10.1038/s41586-020-2771-1⟩

International audience; The ability to recognize information that is incongruous with previous experience is critical for survival. Novelty signals have therefore evolved in the mammalian brain to enhance attention, perception and memory1,2. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaba33f9144c1354f5bcc475d378d7a
https://www.hal.inserm.fr/inserm-02978741/document

Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi

Autor: Yi Tang, Arthur J Huang, Yang Hai

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 21

Nonribosomal peptide synthetases (NRPS) and NRPS-like enzymes have diverse functions in primary and secondary metabolism. By using a structure-guided approach, we uncovered the function of an NRPS-like enzyme with unusual domain architecture, catalyz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b2a6fdff75d6db1f7345427cdb8bc5
https://escholarship.org/uc/item/2c30s6cz