Výsledky vyhledávání - "Arthur J. Boyer"

Evidence for a Carbocation Intermediate during Conversion of Bipinnatin-A and -C into Irreversible Inhibitors of Nicotinic Acetylcholine Receptors

Autor: Stacy M. Thornhill, Arthur J. Boyer, Edward G. Hyde, Stewart N. Abramson

Publikováno v: Journal of Medicinal Chemistry. 38:4704-4709

The lophotoxins are naturally occurring antagonists of nicotinic acetylcholine receptors. These toxins are small diterpenes that irreversibly inhibit nicotinic receptors by specific covalent modification of Tyr 190 in the α-subunits of the receptor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1659f3e21fd1e38dd3bb43559a1fe4
https://doi.org/10.1021/jm00023a010

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Irreversible inhibitors of nicotinic acetylcholine receptors: isolation and structural characterization of the biologically active solvolysis products of bipinnatin-A and bipinnatin-C

Autor: Arthur J. Boyer, Stewart N. Abramson, Pei Tang, Edward G. Hyde, Yan Xu

Publikováno v: Journal of medicinal chemistry. 38(12)

The lophotoxins irreversibly inhibit nicotinic acetylcholine receptors by covalent modification of Tyr 190 in the α-subunits of the receptor. Previous studies have shown that the naturally occurring lophotoxin analogs bipinnatin-A, -B, and -C are ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edac4972b2a1915c07e4ac71d014fedd
https://pubmed.ncbi.nlm.nih.gov/7783154

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