Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Arthur J. A. Leloup"'
Autor:
Arthur J. A. Leloup, Sofie De Moudt, Cor E. Van Hove, Lindsey Dugaucquier, Zarha Vermeulen, Vincent F. M. Segers, Gilles W. De Keulenaer, Paul Fransen
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Induction of hypertension by angiotensin II (AngII) is a widely used experimental stimulus to study vascular aging in mice. It is associated with large artery stiffness, a hallmark of arterial aging and a root cause of increased cardiovascular risk.
Externí odkaz:
https://doaj.org/article/2f5523c85e5c4245a65b7f7bd460bdac
Autor:
Vincent F.M. Segers, Jhana O. Hendrickx, Hadis Shakeri, Jente R A Boen, Sofie De Moudt, Arthur J. A. Leloup, Pieter-Jan Guns, Griet Jacobs, Guido R.Y. De Meyer, Gilles W. De Keulenaer
Publikováno v:
American journal of physiology: heart and circulatory physiology
Endothelial cells (ECs) secrete different paracrine signals that modulate the function of adjacent cells; two examples of these paracrine signals are nitric oxide (NO) and neuregulin-1 (NRG1), a cardioprotective growth factor. Currently, it is undete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56fedd673403f99739e0e4b4e515e00
https://doi.org/10.1152/ajpheart.00914.2020
https://doi.org/10.1152/ajpheart.00914.2020
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 472:1031-1040
Aging and associated progressive arterial stiffening are both important predictors for the development of cardiovascular diseases. Recent evidence showed that autophagy, a catabolic cellular mechanism responsible for nutrient recycling, plays a major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2af2de7635aa5eedf1deb7aafcb2b0
https://doi.org/10.1007/s00424-020-02408-y
https://doi.org/10.1007/s00424-020-02408-y
Autor:
Dorien G. De Munck, Arthur J. A. Leloup, Sofie De Moudt, Guido R. Y. De Meyer, Wim Martinet, Paul Fransen
Publikováno v:
Journal of physiological sciences
The physiology of vascular smooth muscle (VSMC) cells is affected by autophagy, a catabolic cellular mechanism responsible for nutrient recycling. Autophagy-inducing compounds may reverse arterial stiffening, whereas congenital VSMC-specific autophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d48d129d51b9446e16a2a1d36baa68
https://hdl.handle.net/10067/1867480151162165141
https://hdl.handle.net/10067/1867480151162165141
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology
Aim: Cyclic stretch of vascular tissue at any given pressure reveals greater dimensions during unloading than during loading, which determines the cardiac beat-by-beat hysteresis loop on the pressure-diameter/volume relationship. The present study di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b1615728041e5b300b05e18951b719
https://www.frontiersin.org/articles/10.3389/fphys.2021.723972/full
https://www.frontiersin.org/articles/10.3389/fphys.2021.723972/full
Autor:
Bram Boeckx, Nathan Criem, Arthur J. A. Leloup, Manu Beerens, Elizabeth A. V. Jones, Diether Lambrechts, Aernout Luttun, Sofie De Moudt, Jore Van Wauwe, Dorien G. De Munck, An Zwijsen, Carla Geeroms, Tim Vervliet, Sander Craps, Wouter Dheedene, Paul Fransen
Publikováno v:
Circulation research
Rationale: Understanding the mechanisms that regulate arterial flow recovery is important to design treatment options for peripheral artery disease patients ineligible for invasive revascularization. Transcriptional orchestrators of this recovery pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ce34fc7137b62d05072392006b985c
https://lirias.kuleuven.be/handle/123456789/675777
https://lirias.kuleuven.be/handle/123456789/675777
Autor:
Paul Fransen, Guido R.Y. De Meyer, Sofie De Moudt, Arthur J. A. Leloup, Wim Martinet, Dorien G. De Munck, Jhana O. Hendrickx
Publikováno v:
Artery Research, Vol 26, Iss Supplement 1 (2020)
Background: Although generally assumed to be an adaptive response to increased blood pressure (BP), arterial stiffness is now recognized as an independent predictor of cardiovascular (CV) events [1]. Moreover it precedes hypertension in at least two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410d7e38ca9112c31aea99011c7bd0cd
https://www.atlantis-press.com/article/125950039/view
https://www.atlantis-press.com/article/125950039/view
Autor:
Guido R.Y. De Meyer, Jhana O. Hendrickx, Sofie De Moudt, Arthur J. A. Leloup, Dorien G. De Munck, Wim Martinet, Paul Fransen
Publikováno v:
Circulation. 142
Introduction: Endothelial dysfunction (ED) acts as a common player in most cardiovascular (CV) risk factors (e.g. hypertension, smoking) underlining its importance in CV ageing. Therefore, this study aims to characterize ex vivo aortic function chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfbb3fc2902f01a20f1a315e3b51b925
https://doi.org/10.1161/circ.142.suppl_3.15505
https://doi.org/10.1161/circ.142.suppl_3.15505
Publikováno v:
American journal of physiology: heart and circulatory physiology
An important physiological role of the aorta is to convert the pulsatile blood flow that originates in the heart to a nearly continuous flow in the peripheral vessels. Previously, we demonstrated that basal, unstimulated nitric oxide (NO) production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af85f87b02443e8fad7847c570102c3b
https://pubmed.ncbi.nlm.nih.gov/32275471
https://pubmed.ncbi.nlm.nih.gov/32275471
Autor:
S De Moudt, Griet Jacobs, Hadis Shakeri, Arthur J. A. Leloup, G.W. De Keulenaer, G.R.Y. De Meyer, Vincent F.M. Segers, Paul Fransen, P.-J.F Guns
Publikováno v:
European Heart Journal. 40
Background Decreased eNOS activity is the hallmark of endothelial dysfunction and is associated with cardiovascular and renal disorders. Besides NO, endothelial cells produce numerous other small molecules, peptides, and proteins, which modulate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35248c9dfd23affd9d0d835a0cef986b
https://doi.org/10.1093/eurheartj/ehz746.0173
https://doi.org/10.1093/eurheartj/ehz746.0173