Výsledky vyhledávání - "Arthur J Goff"

Akademický článek

Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.

Autor: Todd M Bell, Paul Facemire, Jeremy J Bearss, Jo Lynne Raymond, Jennifer Chapman, Xiankun Zeng, Joshua D Shamblin, Janice A Williams, Douglas W Grosenbach, Dennis E Hruby, Inger K Damon, Arthur J Goff, Eric M Mucker

Publikováno v: PLoS Pathogens, Vol 20, Iss 2, p e1012007 (2024)

Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus. Using archived tissue from a study conducted at the Centers for Disease Control and Prevention we chara

Externí odkaz: https://doaj.org/article/cddf3210406a441fb77eb02b33ee6bb4

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Akademický článek

Natural history of disease in cynomolgus monkeys exposed to Ebola virus Kikwit strain demonstrates the reliability of this non-human primate model for Ebola virus disease.

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0252874 (2021)

Filoviruses (Family Filoviridae genera Ebolavirus and Marburgvirus) are negative-stranded RNA viruses that cause severe health effects in humans and non-human primates, including death. Except in outbreak settings, vaccines and other medical counterm

Externí odkaz: https://doaj.org/article/872942b1dcae494498eca02d622ed9e7

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Akademický článek

Dose Response of MARV/Angola Infection in Cynomolgus Macaques following IM or Aerosol Exposure.

Autor: Sara C Johnston, Kenny L Lin, Nancy A Twenhafel, Jo Lynne W Raymond, Joshua D Shamblin, Suzanne E Wollen, Carly B Wlazlowski, Eric R Wilkinson, Miriam A Botto, Arthur J Goff

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138843 (2015)

Marburg virus infection in humans causes a hemorrhagic disease with a high case fatality rate. Countermeasure development requires the use of well-characterized animal models that mimic human disease. To further characterize the cynomolgus macaque mo

Externí odkaz: https://doaj.org/article/40ea2eb5b327405fba8c961b00b1b7b6

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Akademický článek

Evaluation of Virulence in Cynomolgus Macaques Using a Virus Preparation Enriched for the Extracellular Form of Monkeypox Virus

Autor: Eric M. Mucker, Josh D. Shamblin, Arthur J. Goff, Todd M. Bell, Christopher Reed, Nancy A. Twenhafel, Jennifer Chapman, Marc Mattix, Derron Alves, Robert F. Garry, Lisa E. Hensley

Publikováno v: Viruses, Vol 14, Iss 9, p 1993 (2022)

The 2022 global human monkeypox outbreak emphasizes the importance of maintaining poxvirus research, including enriching a basic understanding of animal models for developing and advancing therapeutics and vaccines. Intravenous administration of monk

Externí odkaz: https://doaj.org/article/7488b9220c6a4b1d88e581edb248f6c2

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Akademický článek

Delayed Disease in Cynomolgus Macaques Exposed to Ebola Virus by an Intranasal Route

Autor: Sara C. Johnston, Catherine L. Wilhelmsen, Joshua Shamblin, Adrienne Kimmel, Justine Zelko, Suzanne Wollen, Arthur J. Goff

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Ebola virus remains a significant public health concern due to high morbidity and mortality rates during recurrent outbreaks in endemic areas. Therefore, the development of countermeasures against Ebola virus remains a high priority, and requires the

Externí odkaz: https://doaj.org/article/167de429dec24028af0162f48d4d8f30

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Akademický článek

Virus-encoded miRNAs in Ebola virus disease

Autor: Janice Duy, Anna N. Honko, Louis A. Altamura, Sandra L. Bixler, Suzanne Wollen-Roberts, Nadia Wauquier, Aileen O’Hearn, Eric M. Mucker, Joshua C. Johnson, Joshua D. Shamblin, Justine Zelko, Miriam A. Botto, James Bangura, Moinya Coomber, M. Louise Pitt, Jean-Paul Gonzalez, Randal J. Schoepp, Arthur J. Goff, Timothy D. Minogue

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

Abstract Ebola virus (EBOV) is a negative-strand RNA virus that replicates in the cytoplasm and causes an often-fatal hemorrhagic fever. EBOV, like other viruses, can reportedly encode its own microRNAs (miRNAs) to subvert host immune defenses. miRNA

Externí odkaz: https://doaj.org/article/277f04bdc0d1417dae0bd78593c2b695

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Retrospective detection of monkeypox virus in the testes of nonhuman primate survivors

Autor: Jun Liu, Eric M. Mucker, Jennifer L. Chapman, April M. Babka, Jamal M. Gordon, Ashley V. Bryan, Jo Lynne W. Raymond, Todd M. Bell, Paul R. Facemire, Arthur J. Goff, Aysegul Nalca, Xiankun Zeng

Publikováno v: Nature Microbiology. 7:1980-1986

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86395478b0dd2206f64ba2445dc83465
https://doi.org/10.1038/s41564-022-01259-w

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Detecting Pathogen Exposure During the Non-symptomatic Incubation Period Using Physiological Data: Proof of Concept in Non-human Primates

Autor: Catherine Cabrera, Jack G. Fleischman, S.K. Davis, Tejash Patel, Albert Swiston, Kajal T. Claypool, Mark Hernandez, Bret K. Purcell, Arthur J. Goff, Sara C. Johnston, Siddharth Samsi, Albert Reuther, Lisa E. Hensley, William D. Pratt, Franco Rossi, Lauren Milechin, John C. Trefry, Greg Ciccarelli, Anna N. Honko

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)

Background and Objectives: Early warning of bacterial and viral infection, prior to the development of overt clinical symptoms, allows not only for improved patient care and outcomes but also enables faster implementation of public health measures (p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0988a9e23d2c96238eb054152488239f
http://europepmc.org/articles/PMC8451540

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