Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Arthur H. Roach"'
2
Positive–negative epitope-tagging of β amyloid precursor protein to identify inhibitors of Aβ processing
Autor: Thomas J. Mitchell, Andrew M. Stern, Arthur H. Roach, Dietmar Seiffert, Yutian Zhan, Reinhard Grzanna
Publikováno v: Molecular Brain Research. 84:115-126
In this report, a novel positive-negative epitope tagging approach was developed to study the cellular processing of beta amyloid precursor protein (beta APP). Amino acids centered around the alpha-secretase cleavage site within the A beta sequence w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c113edb1f851fc41ae22c599b96ecc78
https://doi.org/10.1016/s0169-328x(00)00230-8
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3
Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent gamma-secretase inhibitors
Autor: Yang Michael G, Richard E. Olson, J S Wells, Ruth R. Wexler, Dilip P. Modi, Lorin A. Thompson, Mercy M. Ramanjulu, David W. Robertson, Jianliang Shi, Brian M. Cochran, Robert Zaczek, Arthur H. Roach, Mark A. Wolf
Publikováno v: Bioorganicmedicinal chemistry letters. 17(14)
We report the synthesis of benzoazepine-derived cyclic malonamides (2) and aminoamides (3) as gamma-secretase inhibitors for the potential treatment of Alzheimer's disease. The in vitro structure-activity relationships of 2 and 3 along with dog pharm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f56307d6a2461dcdf7c119279f61f9
https://pubmed.ncbi.nlm.nih.gov/17502143
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4
Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors
Autor: Mercy Ramanjulu, Ann Y. Liauw, Thomas P. Maduskuie, Jere E. Meredith, Jeffrey N. Higaki, Robert Zaczek, Barbara Cordell, Arthur H. Roach, Dietmar A. Seiffert, David Robertson, Padmaja Kasireddy-Polam, Lorin A. Thompson, Marcie A. Glicksman, Stephen E. Mercer, Andrew P. Combs, Richard E. Olson, Rui-Qin Liu
Publikováno v: Bioorganicmedicinal chemistry letters. 16(9)
The synthesis, evaluation, and structure-activity relationships of a series of succinoyl lactam inhibitors of the Alzheimer's disease gamma-secretase are described. Beginning with a screening hit with broad proteinase activity, optimization provided
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15589f134d4cb016d3cf88127c79f08f
https://pubmed.ncbi.nlm.nih.gov/16473009
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6
Identification and characterization of presenilin-independent Notch signaling
Autor: Magali Kitzmann, Dorit B. Donoviel, Daniel R. Foltz, Dietmar A. Seiffert, Jeffrey S. Nye, Arthur H. Roach, Richard E. Olson, Alan Bernstein, Lorin A. Thompson, Bridget E. Berechid
Publikováno v: The Journal of biological chemistry. 277(10)
Presenilin (PS) proteins control the proteolytic cleavage that precedes nuclear access of the Notch intracellular domain. Here we observe that a partial activation of the HES1 promoter can be detected in PS1/PS2 (PS1/2) double null cells using Notch1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9c83326fe777e8d941c375a5862f42
https://pubmed.ncbi.nlm.nih.gov/11756438
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7
Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors
Autor: Jere E. Meredith, Andrew M. Stern, Lorin A. Thompson, Arthur H. Roach, Cynthia M. Rominger, Qian Wang, Fude Yang, David W. Robertson, Barbara Cordell, Dietmar Seiffert, Stephen P. Arneric, Susan M. Spitz, Jodi D. Bradley, Shimoga R. Prakash, Paul R. Hartig, Richard E. Olson, Robert Zaczek, Andrew P. Combs, David H. Rominger, Jeffrey N. Higaki, Robert A. Copeland
Publikováno v: The Journal of biological chemistry. 275(44)
Presenilins are integral membrane protein involved in the production of amyloid beta-protein. Mutations of the presenilin-1 and -2 gene are associated with familial Alzheimer's disease and are thought to alter gamma-secretase cleavage of the beta-amy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097d735acb105b526be7b0f185914ad9
https://pubmed.ncbi.nlm.nih.gov/10915801
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8
Catfish vitellogenin and its messenger RNA are smaller than their chicken and Xenopus counterparts
Autor: Peter L. Davies, Arthur H. Roach
Publikováno v: Biochimica et biophysica acta. 610(2)
Injection of male bullheads ( Ameiurus nebulosus ) with estradiol induced the production of a major serum phosphoprotein of molecular weight 145 000. This protein was immunoprecipitable by antisera raised against lipovitellin from bullhead eggs and w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88051b79402d1da57f94528cafa30a1
https://pubmed.ncbi.nlm.nih.gov/7213633
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9
Biochemistry of information storage in the nervous system
Autor: Joshua E. Adler, Ira B. Black, Arthur H. Roach, Cheryl F. Dreyfus, E F Lagamma, Wilma F. Friedman
Publikováno v: Science (New York, N.Y.). 236(4806)
The use of molecular biological approaches has defined new mechanisms that store information in the mammalian nervous system. Environmental stimuli alter steady-state levels of messenger RNA species encoding neurotransmitters, thereby altering synapt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2995e3995038c5ee116523d864c13c29
https://pubmed.ncbi.nlm.nih.gov/2884727
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