Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Arthur Glasfeld"'
Autor:
Adam C. Oken, Nicolas E. Lisi, Ipsita Krishnamurthy, Alanna E. McCarthy, Michael H. Godsey, Arthur Glasfeld, Steven E. Mansoor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract P2X receptors are trimeric ATP-gated ion channels that activate diverse signaling cascades. Due to its role in apoptotic pathways, selective activation of P2X7 is a potential experimental tool and therapeutic approach in cancer biology. Howe
Externí odkaz:
https://doaj.org/article/3c89490806f045458206f861b602e1d4
Autor:
Tessa R. Young, Maria Alessandra Martini, Andrew W. Foster, Arthur Glasfeld, Deenah Osman, Richard J. Morton, Evelyne Deery, Martin J. Warren, Nigel J. Robinson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The connection between metal binding to proteins and availabilities of different metals in cells has been unclear. Here, the authors report a metalation-calculator that takes into account competition between metals and their variable accessibility, a
Externí odkaz:
https://doaj.org/article/47a874e4fffe4f87807b18d00ce0daa2
Autor:
Arthur Glasfeld, Nigel J. Robinson
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry, 2020, Vol.25(4), pp.543-545 [Peer Reviewed Journal]
Journal of Biological Inorganic Chemistry
Journal of Biological Inorganic Chemistry
The association of proteins with metals, metalation, is challenging because the tightest binding metals are rarely the correct ones. Inside cells, correct metalation is enabled by controlled bioavailability plus extra mechanisms for tricky combinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89adaee067e87113585fcf920a8f53b0
http://dro.dur.ac.uk/31080/
http://dro.dur.ac.uk/31080/
Autor:
Arthur Glasfeld, James Chen, Jazz Weisman, Patrick Monette, Grace A. Spatafora, Foster Seybert, Richard Brach, Kelsey Goguen, Roger Winters, Annie Cowan
Streptococcus mutans , one of ∼600 bacterial species in the human oral cavity, is among the most acidogenic constituents of the plaque biofilm. Considered to be the primary causative agent of dental caries, S. mutans harbors a 25-kDa SloR metallore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e05c07ac8377858a8eeac4b92923888
https://europepmc.org/articles/PMC6018352/
https://europepmc.org/articles/PMC6018352/
Autor:
Jazz Weisman, Patrick Monette, Annie Cowan, James Chen, Roger Winters, Kelsey Goguen, Arthur Glasfeld, Richard Brach, Grace A. Spatafora, Foster Seybert
Streptococcus mutans, one of ∼600 bacterial species in the human oral cavity, is among the most acidogenic constituents of the plaque biofilm. Considered to be the primary causative agent of dental caries,S. mutansharbors a 25kDa SloR metalloregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d259a09f3e833d028fdeac4fc561311
https://doi.org/10.1101/301416
https://doi.org/10.1101/301416
Autor:
John Corbett, William Daly, Justin Collins, Louis P. Cornacchione, Wendy A. Breyer, Diego Galan, Arthur Glasfeld, Michael Wysota, Grace A. Spatafora, Patrick Tivnan, Dillon B. Nye, Talya Levitz
Publikováno v:
Journal of bacteriology. 197(22)
Streptococcus mutans is the causative agent of dental caries, a significant concern for human health, and therefore an attractive target for therapeutics development. Previous work in our laboratory has identified a homodimeric, manganese-dependent r
Publikováno v:
Biochemistry. 45:3493-3505
The manganese transport regulator (MntR) of Bacillus subtilis is activated by Mn(2+) to repress transcription of genes encoding transporters involved in the uptake of manganese. MntR is also strongly activated by cadmium, both in vivo and in vitro, b
Publikováno v:
Nature Structural & Molecular Biology. 10:652-657
The Bacillus subtilis manganese transport regulator, MntR, binds Mn2+ as an effector and is a repressor of transporters that import manganese. A member of the diphtheria toxin repressor (DtxR) family of metalloregulatory proteins, MntR exhibits selec
Publikováno v:
Journal of Biological Chemistry. 272:22648-22653
The purine repressor, PurR, is the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli. This dimeric transcription factor is activated to bind to cognate DNA operator sites by initially binding either of its physio
Autor:
Dagmar Ringe, Arnon Lavie, Steven C. Carlson, Timothy N. Tanada, Arthur Glasfeld, Gregory K. Farber, Karen N. Allen, Daniel P. Gerrity, Gregory A. Petsko
Publikováno v:
Biochemistry. 33:1488-1494
The distinct roles of the two magnesium ions essential to the activity of D-xylose isomerase from Streptomyces olivochromogenes were examined. The enzyme-magnesium complex was isolated, and the stoichiometry of cation binding determined by neutron ac