Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Arthur G, Pratt"'
Autor:
Abigail Gault, Linda Hogarth, Kristian C Williams, Alastair Greystoke, Neil Rajan, Ally Speight, Christopher A Lamb, Alison Bridgewood, Lisa-Jayne Brown-Schofield, Fiona Rayner, John D Isaacs, Jérémie Nsengimana, Christopher J Stewart, Amy E Anderson, Ruth Plummer, Arthur G Pratt
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Checkpoint inhibitors (CPIs) are widely used in cancer treatment, with transformative impacts on survival. They nonetheless carry a significant risk of toxicity in the form of immune-related adverse events (IrAEs), which may be su
Externí odkaz:
https://doaj.org/article/e1ba05f0593545e687f9967895eaede1
Autor:
Kenneth F. Baker, David McDonald, Gillian Hulme, Rafiqul Hussain, Jonathan Coxhead, David Swan, Axel R. Schulz, Henrik E. Mei, Lucy MacDonald, Arthur G. Pratt, Andrew Filby, Amy E. Anderson, John D. Isaacs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Immune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing and remitting flares of inflammation. However, the unpredictability of disease flares impedes their study. Addressing this critical knowledge gap, we use
Externí odkaz:
https://doaj.org/article/34a7ab6817b24901ae14c64e18ae1869
Autor:
John D Isaacs, Dawn Craig, Jingky Lozano-Kuehne, Arthur G Pratt, Michelle Bardgett, Madeleine Still, Leher Gumber, Luke Ouma, Opeyemi Agbeleye, Alex Inskip, Ross Fairbairn, James MS Wason
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Objective International trials can be challenging to operationalise due to incompatibilities between country-specific policies and infrastructures. The aim of this systematic review was to identify the operational complexities of conducting internati
Externí odkaz:
https://doaj.org/article/20b4f9f679554873aead11d79b437234
Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis
Autor:
Dennis W Lendrem, Ann W Morgan, Amy E Anderson, Arthur G Pratt, Philip M Brown, Najib Naamane
Publikováno v:
RMD Open, Vol 10, Iss 1 (2024)
Objectives Long-term outcomes in rheumatoid arthritis (RA) depend on early and effective disease control. Methotrexate (MTX) remains the first-line disease modifying therapy, however there are no biomarkers with which to identify those most likely to
Externí odkaz:
https://doaj.org/article/bd3498f6038a4151b7f91f71f6607c11
Autor:
Gwenda Simons, Rebecca Birch, Joanne Stocks, Elspeth Insch, Rob Rijckborst, Georgiana Neag, Heidi McColm, Leigh Romaniuk, Claire Wright, Bethan E. Phillips, Simon W. Jones, Arthur G. Pratt, Stefan Siebert, Karim Raza, Marie Falahee
Publikováno v:
BMC Rheumatology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract Background While the integration of patient and public involvement (PPI) in clinical research is now widespread and recommended as standard practice, meaningful PPI in pre-clinical, discovery science research is more difficult to achieve. On
Externí odkaz:
https://doaj.org/article/a7d622988a2849418b8cd732ef1219f0
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1297 (2024)
The observation that certain therapeutic strategies for targeting inflammation benefit patients with distinct immune-mediated inflammatory diseases (IMIDs) is exemplified by the success of TNF blockade in conditions including rheumatoid arthritis, ul
Externí odkaz:
https://doaj.org/article/6c987adbb7a64a8bb3f2d7e34986f26b
Autor:
Rachel E. Crossland, Anna Albiero, Clara Sanjurjo‐Rodríguez, Monica Reis, Anastasia Resteu, Amy E. Anderson, Anne M. Dickinson, Arthur G. Pratt, Mark Birch, Andrew W. McCaskie, Elena Jones, Xiao‐nong Wang
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 1, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EV) and the microRNAs that they contain are increasingly recognised as a rich source of informative biomarkers, reflecting pathological processes and fundamental biological pathways and responses. Their presence in bi
Externí odkaz:
https://doaj.org/article/39d48e4470ce428d955614163bd77cde
Autor:
Kristian C. Williams, Abigail Gault, Amy E. Anderson, Christopher J. Stewart, Christopher A. Lamb, R. Ally Speight, Neil Rajan, Ruth Plummer, Arthur G. Pratt
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Checkpoint inhibitors (CPIs) are monoclonal antibodies which, by disrupting interactions of immune checkpoint molecules with their ligands, block regulatory immune signals otherwise exploited by cancers. Despite revolutionary clinical benefits, CPI u
Externí odkaz:
https://doaj.org/article/b30251e406b74de18123be0e7551e13b
Autor:
Fiona Cooke, Mary Neal, Matthew J. Wood, I. Jolanda M. de Vries, Amy E. Anderson, Julie Diboll, Arthur G. Pratt, James Stanway, Ioana Nicorescu, Nicholas Moyse, Dawn Hiles, David Caulfield, Anne M. Dickinson, Andrew M. Blamire, Pete Thelwall, John D. Isaacs, Catharien M. U. Hilkens
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tolerogenic dendritic cell (tolDC) therapies aim to restore self-tolerance in patients suffering from autoimmune diseases. Phase 1 clinical trials with tolDC have shown the feasibility and safety of this approach, but have also highlighted a lack of
Externí odkaz:
https://doaj.org/article/47a487e2cf1e43fca48e6bf3f7d8fb41
Autor:
Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt, Jonathan Prichard, Karim Raza, Stefan Siebert, Deborah Stocken, M. Dawn Teare, Stephen Young, John D. Isaacs
Publikováno v:
BMC Rheumatology, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract Background Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flares), converting diseas
Externí odkaz:
https://doaj.org/article/7bbdfdc9383c46daab23a559ec6892ed