Zobrazeno 1 - 10
of 17 874
pro vyhledávání: '"Arthur G"'
Autor:
Abigail Gault, Linda Hogarth, Kristian C Williams, Alastair Greystoke, Neil Rajan, Ally Speight, Christopher A Lamb, Alison Bridgewood, Lisa-Jayne Brown-Schofield, Fiona Rayner, John D Isaacs, Jérémie Nsengimana, Christopher J Stewart, Amy E Anderson, Ruth Plummer, Arthur G Pratt
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Checkpoint inhibitors (CPIs) are widely used in cancer treatment, with transformative impacts on survival. They nonetheless carry a significant risk of toxicity in the form of immune-related adverse events (IrAEs), which may be su
Externí odkaz:
https://doaj.org/article/e1ba05f0593545e687f9967895eaede1
Autor:
Kenneth F. Baker, David McDonald, Gillian Hulme, Rafiqul Hussain, Jonathan Coxhead, David Swan, Axel R. Schulz, Henrik E. Mei, Lucy MacDonald, Arthur G. Pratt, Andrew Filby, Amy E. Anderson, John D. Isaacs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Immune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing and remitting flares of inflammation. However, the unpredictability of disease flares impedes their study. Addressing this critical knowledge gap, we use
Externí odkaz:
https://doaj.org/article/34a7ab6817b24901ae14c64e18ae1869
Autor:
Arthur G. Fink, Roxanna S. Delima, Alexandra R. Rousseau, Camden Hunt, Natalie E. LeSage, Aoxue Huang, Monika Stolar, Curtis P. Berlinguette
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Industrial hydrogen peroxide (H2O2) is synthesized using carbon-intensive H2 gas production and purification, anthraquinone hydrogenation, and anthrahydroquinone oxidation. Electrochemical hydrogenation (ECH) of anthraquinones offers a carbo
Externí odkaz:
https://doaj.org/article/d8b21267c60145658692265e20db1a31
Autor:
John D Isaacs, Dawn Craig, Jingky Lozano-Kuehne, Arthur G Pratt, Michelle Bardgett, Madeleine Still, Leher Gumber, Luke Ouma, Opeyemi Agbeleye, Alex Inskip, Ross Fairbairn, James MS Wason
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Objective International trials can be challenging to operationalise due to incompatibilities between country-specific policies and infrastructures. The aim of this systematic review was to identify the operational complexities of conducting internati
Externí odkaz:
https://doaj.org/article/20b4f9f679554873aead11d79b437234
Publikováno v:
European Respiratory Review, Vol 33, Iss 171 (2024)
Respiratory viral infections are a major public health problem, with much of their morbidity and mortality due to post-viral lung diseases that progress and persist after the active infection is cleared. This paradigm is implicated in the most common
Externí odkaz:
https://doaj.org/article/52053c9ec17e48adbc0a4e10ba4774bc
Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis
Autor:
Dennis W Lendrem, Ann W Morgan, Amy E Anderson, Arthur G Pratt, Philip M Brown, Najib Naamane
Publikováno v:
RMD Open, Vol 10, Iss 1 (2024)
Objectives Long-term outcomes in rheumatoid arthritis (RA) depend on early and effective disease control. Methotrexate (MTX) remains the first-line disease modifying therapy, however there are no biomarkers with which to identify those most likely to
Externí odkaz:
https://doaj.org/article/bd3498f6038a4151b7f91f71f6607c11
Autor:
Gwenda Simons, Rebecca Birch, Joanne Stocks, Elspeth Insch, Rob Rijckborst, Georgiana Neag, Heidi McColm, Leigh Romaniuk, Claire Wright, Bethan E. Phillips, Simon W. Jones, Arthur G. Pratt, Stefan Siebert, Karim Raza, Marie Falahee
Publikováno v:
BMC Rheumatology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract Background While the integration of patient and public involvement (PPI) in clinical research is now widespread and recommended as standard practice, meaningful PPI in pre-clinical, discovery science research is more difficult to achieve. On
Externí odkaz:
https://doaj.org/article/a7d622988a2849418b8cd732ef1219f0
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1297 (2024)
The observation that certain therapeutic strategies for targeting inflammation benefit patients with distinct immune-mediated inflammatory diseases (IMIDs) is exemplified by the success of TNF blockade in conditions including rheumatoid arthritis, ul
Externí odkaz:
https://doaj.org/article/6c987adbb7a64a8bb3f2d7e34986f26b
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Membrane proteins play critical roles in disease and in the disposition of many pharmaceuticals. A prime example is P-glycoprotein (Pgp) which moves a diverse range of drugs across membranes and out of the cell before a therapeutic payload c
Externí odkaz:
https://doaj.org/article/ce575d40bbff4a039275c8cc5fffc557
Autor:
Edirisa Juniour Nsubuga, Arthur G. Fitzmaurice, Allan Komakech, Tom Dias Odoi, Daniel Kadobera, Lilian Bulage, Benon Kwesiga, Peter James Elyanu, Alex Riolexus Ario, Julie R. Harris
Publikováno v:
BMC Public Health, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Widespread COVID-19 vaccine uptake can facilitate epidemic control. A February 2021 study in Uganda suggested that public vaccine uptake would follow uptake among leaders. In May 2021, Baylor Uganda led community dialogue meetings
Externí odkaz:
https://doaj.org/article/8c4ef3bd4c6a4172bf18e8e9a54b13e9